Patents by Inventor Alastair Hodges
Alastair Hodges has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220033379Abstract: Disclosed herein are new compounds, pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).Type: ApplicationFiled: September 27, 2019Publication date: February 3, 2022Inventors: Peter Machin, Mark Chambers, Alastair Hodges, Andrew Sharpe, Grant Wishart, Benjamin Perry, Sylvain Celanire, Freddy Heitz
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Publication number: 20190046515Abstract: The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).Type: ApplicationFiled: October 16, 2018Publication date: February 14, 2019Inventors: PETER MACHIN, ANDREW SHARPE, CHRISTOPHER JAMES LOCK, MARK S. CHAMBERS, ALASTAIR HODGES, VIVIENNE ALLEN, JOHN M. ELLARD
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Patent number: 10130619Abstract: The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).Type: GrantFiled: December 16, 2015Date of Patent: November 20, 2018Assignee: GENKYOTEX SUISSE SAInventors: Peter Machin, Andrew Sharpe, Christopher James Lock, Mark S. Chambers, Alastair Hodges, Vivienne Allen, John M. Ellard
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Publication number: 20170348296Abstract: The present invention is related to amino thiazole derivatives of Formula (I), pharmaceutical composition thereof and to their use for the treatment and/or prophylaxis of disorders or conditions related to Nicotinamide adenine dinucleotide phosphate oxidase (NADPH Oxidase).Type: ApplicationFiled: December 16, 2015Publication date: December 7, 2017Inventors: PETER MACHIN, ANDREW SHARPE, CHRISTOPHER JAMES LOCK, MARK S. CHAMBERS, ALASTAIR HODGES, VIVIENNE ALLEN, JOHN M. ELLARD
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Patent number: 8951749Abstract: Disclosed herein are devices for detecting the presence of a target analyte in a fluid sample. The biosensor device can comprise at least a reaction chamber and a detection chamber. The device can comprise a amplifying mechanism such that one target analyte molecule present in the fluid sample can lead to generation/activation of multiple detection agent molecules, and therefore, an amplified signal. Also disclosed are the methods of manufacturing and using such a biosensor device.Type: GrantFiled: July 10, 2009Date of Patent: February 10, 2015Assignee: Universal Biosensors Pty LtdInventors: Dennis Rylatt, Alastair Hodges
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Patent number: 8685714Abstract: This invention describes a quantitative, inexpensive, disposable immunosensor that requires no wash steps and thus generates no liquid waste. Moreover, in preferred embodiments of the sensor no timing steps are required of the user, and the sensor can be readily adapted to antigen-antibody interactions over a wide kinetic range.Type: GrantFiled: April 22, 2004Date of Patent: April 1, 2014Assignee: Universal Biosensors Pty LtdInventors: Alastair Hodges, Ron Chatelier
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Patent number: 8323464Abstract: Electrochemical sensors for investigating a physiological sample and methods of manufacture are disclosed. The sensor includes a longitudinally extending reaction cell, having electrodes and a reagent, and laterally spaced electrical contact points for electrically communication with a meter. An array of such sensors is further disclosed including connective flaps for joining adjacent sensors. In use, the array of sensors can be stored in a folded configuration and dispensed individually.Type: GrantFiled: May 25, 2005Date of Patent: December 4, 2012Assignee: Universal Biosensors Pty LtdInventors: Jerry T. Pugh, Alastair Hodges, Garry Chambers
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Patent number: 8192599Abstract: Electrochemical sensors for investigating a physiological sample and methods of manufacture are disclosed. The sensor includes an electrochemical reaction cell, having electrodes and a reagent, and laterally spaced electrical contact points for electrically communication with a meter. Further described herein is a multi-chambered sensor having an electrochemical reaction cell and an immunological cell. The multi-chambered cell can also include a pre-chamber.Type: GrantFiled: November 21, 2005Date of Patent: June 5, 2012Assignee: Universal Biosensors Pty LtdInventors: Alastair Hodges, Jerry T. Pugh, Garry Chambers
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Publication number: 20110111425Abstract: Disclosed herein are devices for detecting the presence of a target analyte in a fluid sample. The biosensor device can comprise at least a reaction chamber and a detection chamber. The device can comprise a amplifying mechanism such that one target analyte molecule present in the fluid sample can lead to generation/activation of multiple detection agent molecules, and therefore, an amplified signal. Also disclosed are the methods of manufacturing and using such a biosensor device.Type: ApplicationFiled: July 10, 2009Publication date: May 12, 2011Applicant: Universal Birosensors Pty Ltd.Inventors: Dennis Rylatt, Alastair Hodges
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Patent number: 7846312Abstract: The present invention relates to electrochemical cells including a connector which mates with a connection device to provide electrical connection to meter circuitry.Type: GrantFiled: August 16, 2005Date of Patent: December 7, 2010Assignee: LifeScan, Inc.Inventors: Alastair Hodges, Garry Chambers
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Publication number: 20100270178Abstract: Methods and apparatus for electrochemically determining an analyte concentration value in a physiological sample are disclosed. The methods include using a test strip in which two time-current transients are measured by a meter electrically connected to an electrochemical test strip. Integrative current values are derived from the time-current transients and used in the calculation of analyte concentration.Type: ApplicationFiled: July 2, 2010Publication date: October 28, 2010Applicant: LifeScan, Inc.Inventors: Sherry Guo, Alastair Hodges, Ronald Christopher Chatelier, Bin Zhang
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Patent number: 7819283Abstract: A strip ejection system for holding and ejecting a strip is provided. The system includes a body and a strip movement section. The strip moving section includes all elements of the system that are involved with moving the strip, including a pressing element for pressing against the strip to move the strip from a first position to a second position. The pressing element is the only element of the strip movement section that is movable relative to the body.Type: GrantFiled: February 17, 2005Date of Patent: October 26, 2010Assignee: Universal Biosensors Pty LtdInventors: Garry Chambers, Alastair Hodges, David Sayer
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Patent number: 7749371Abstract: Methods and apparatus for electrochemically determining an analyte concentration value in a physiological sample are disclosed. The methods include using a test strip in which two time-current transients are measured by a meter electrically connected to an electrochemical test strip. Integrative current values are derived from the time-current transients and used in the calculation of analyte concentration.Type: GrantFiled: September 30, 2005Date of Patent: July 6, 2010Assignee: LifeScan, Inc.Inventors: Sherry Guo, Alastair Hodges, Ronald Chatelier, Bin Zhang
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Publication number: 20090020438Abstract: The present invention relates to electrochemical cells including a first working electrode 32, a first counter electrode 34, a second working electrode 36, and a second counter electrode 38, wherein the electrodes are spaced such that reaction products from the first counter electrode 34 arrive at the first working electrode 32, and reaction products from the first and second counter electrodes 34, 38 do not reach the second working electrode 36. Also provided is a method of using such electrochemical cells for determining the concentration of a reduced or oxidized form of a redox species with greater accuracy than can be obtained using an electrochemical cell having a single working and counter electrode.Type: ApplicationFiled: August 22, 2008Publication date: January 22, 2009Applicant: LIFESCAN, INC.Inventor: Alastair Hodges
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Patent number: 7431814Abstract: A biosensor for use in determining a concentration of a component in an aqueous liquid sample is provided including: an electrochemical cell having a first electrically resistive substrate having a thin layer of electrically conductive material, a second electrically resistive substrate having a thin layer of electrically conductive material, the substrates being disposed with the electrically conductive materials facing each other and being separated by a sheet including an aperture, the wall of which aperture defines a cell wall and a sample introduction aperture whereby the aqueous liquid sample may be introduced into the cell; and a measuring circuit.Type: GrantFiled: May 12, 2004Date of Patent: October 7, 2008Assignee: LifeScan, Inc.Inventors: Alastair Hodges, Thomas W. Beck, Oddvar Johansen, Ian Andrew Maxwell
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Patent number: 7431820Abstract: The present invention relates to electrochemical cells including a first working electrode 32, a first counter electrode 34, a second working electrode 36, and a second counter electrode 38, wherein the electrodes are spaced such that reaction products from the first counter electrode 34 arrive at the first working electrode 32, and reaction products from the first and second counter electrodes 34, 38 do not reach the second working electrode 36. Also provided is a method of using such electrochemical cells for determining the concentration of a reduced or oxidized form of a redox species with greater accuracy than can be obtained using an electrochemical cell having a single working and counter electrode.Type: GrantFiled: October 1, 2002Date of Patent: October 7, 2008Assignee: LifeScan, Inc.Inventor: Alastair Hodges
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Publication number: 20080121533Abstract: The present invention provides a metal electrode stabilised by a coating, the coating comprising a sulfur containing moiety in its molecular structure. The coating may also include a hydrophilic group and a spacer between the sulfur containing moiety and the hydrophilic group. Preferably, the sulfur containing moiety is selected from the group comprising thiol, disulfide and SOx, and the hydrophilic group is selected from the group comprising hydroxyl, amine, carboxyl, carbonyl, oligo (ethylene oxide) chain, and zwitterionic species. Compounds useful in the present invention include 2-mercaptoethanol, 2-mercaptoethylamine, 3-mercaptopropionic acid, thiophene, 4-carboxythiophene, cysteine, homocysteine, and cystine.Type: ApplicationFiled: October 29, 2007Publication date: May 29, 2008Applicant: LifeScan, Inc.Inventors: Alastair Hodges, Ronald Chatelier
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Publication number: 20080081976Abstract: The invention disclosed in this application is a method and device for combining the sampling and analyzing of sub-dermal fluid samples, e.g., interstitial fluid or whole blood, in a device suitable for hospital bedside and home use. It is applicable to any analyte that exists in a usefully representative concentration in the fluid, and is especially suited to the monitoring of glucose.Type: ApplicationFiled: October 29, 2007Publication date: April 3, 2008Applicant: LifeScan, Inc.Inventors: Alastair Hodges, Ronald Chatelier, Garry Chambers
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Publication number: 20080073207Abstract: Mediator stabilized reagent compositions and methods for their use in electrochemical analyte determination assays are provided. The subject reagent compositions include an enzyme, a redox mediator and a mediator-stabilizing buffer. Optionally, the reagent compositions may further include one or more of a wetting agent, detergent, enzyme cofactor and combinations thereof. Also provided are electrochemical test strips that include the subject reagent compositions, systems and kits that include the same as well as methods for using the same in analyte detection assays. The subject invention finds use in a variety of different applications, including glucose concentration determination applications.Type: ApplicationFiled: October 31, 2007Publication date: March 27, 2008Inventors: Maria Teodorczyk, Ronald Chatelier, Alastair Hodges, Timothy Ohara, Remy Dato
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Publication number: 20070227912Abstract: Disclosed herein are methods and apparatus for determining analyte concentration in a rapid and accurate manner. The methods include depositing a physiological sample in an electrochemical cell and finding a first and second current transient. Peak current values are obtained from the first and second peak current values and used to reduce the influence of interferents in a current value. Based on this “corrected” current value, an accurate analyte concentration can be determined.Type: ApplicationFiled: March 31, 2006Publication date: October 4, 2007Applicant: LifeScan, Inc.Inventors: Ronald Chatelier, Alastair Hodges, Bruce Verity