Abstract: The present invention relates to a process for preparing acyloxymethyl esters of (4S)-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxylic acid of the formula (IIa) by optical resolution of the compound of the formula (II) using a hydrolase. The invention also relates to a process for preparing (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridine-3-carboxamide of the formula (Ia), wherein the process comprises the optical resolution of the compound of the formula (II) using a hydrolase. The invention additionally also relates to the use of a hydrolase in a process for preparing a compound of formula (IIa). The invention further relates to the use of a hydrolase in a process for preparing a compound of formula (Ia).

Abstract: An expandable item carrying device facilitates carrying items such as groceries and the like. The device includes a container having a bottom wall and a perimeter wall coupled to and extending upwardly from a perimeter edge of the bottom wall defining an interior space. A top edge of the perimeter wall defines an opening into the interior space. The perimeter wall has a pair of opposed ends sides and a pair of longitudinal sides extending between the opposed end sides. The longitudinal sides and the bottom wall are compactable along a longitudinal axis of the bottom wall. A primary handle comprises opposed ends coupled to a first one of the longitudinal sides of the perimeter wall.