Patents by Inventor Albena Vergilieva Valevska

Albena Vergilieva Valevska has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PRODUCTION OF CATALYTICALLY ACTIVE TYPE I SULFATASE
    Publication number: 20220204952
    Abstract: The present disclosure provides methods for producing activated type I sulfatases, or functional fragments thereof, using Formylglycine Generating Enzymes (FGEs). Also featured by the disclosure are recombinant fungal (e.g., Yarrowia lipolytica) cells expressing the FGE and, in some embodiments, type I sulfatases, or functional fragments thereof, and/or additional accessory enzymes. The disclosure also provides activated type I sulfatases or functional fragments thereof, made by the disclosed methods and therapeutic methods using the activated type I sulfatases or functional fragments thereof.
    Type: Application
    Filed: January 12, 2022
    Publication date: June 30, 2022
    Inventors: Wouter Vervecken, Stefan Simonne Prudent Eugène Christine Ryckaert, Albena Vergilieva Valevska
  • PRODUCTION OF CATALYTICALLY ACTIVE TYPE I SULFATASE
    Publication number: 20190040368
    Abstract: The present disclosure provides methods for producing activated type I sulfatases, or functional fragments thereof, using Formylglycine Generating Enzymes (FGEs). Also featured by the disclosure are recombinant fungal (e.g., Yarrowia lipolytica) cells expressing the FGE and, in some embodiments, type I sulfatases, or functional fragments thereof, and/or additional accessory enzymes. The disclosure also provides activated type I sulfatases or functional fragments thereof, made by the disclosed methods and therapeutic methods using the activated type I sulfatases or functional fragments thereof.
    Type: Application
    Filed: March 5, 2014
    Publication date: February 7, 2019
    Inventors: Wouter VERVECKEN, Stefan Simonne Prudent Eugène Christine Ryckaert, Albena Vergilieva Valevska
  • Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
    Patent number: 10011857
    Abstract: The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
    Type: Grant
    Filed: March 31, 2016
    Date of Patent: July 3, 2018
    Assignee: Oxyrane UK Limited
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken, Albena Vergilieva Valevska, Gwenda Noëlla Pynaert
  • MANNOSIDASES CAPABLE OF UNCAPPING MANNOSE-1-PHOSPHO-6-MANNOSE LINKAGES AND DEMANNOSYLATING PHOSPHORYLATED N-GLYCANS AND METHODS OF FACILITATING MAMMALIAN CELLULAR UPTAKE OF GLYCOPROTEINS
    Publication number: 20160251693
    Abstract: The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
    Type: Application
    Filed: March 31, 2016
    Publication date: September 1, 2016
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken, Albena Vergilieva Valevska, Gwenda Noëlla Pynaert
  • Mannosidases capable of uncapping mannose-1-phospho-6-mannose linkages and demannosylating phosphorylated N-glycans and methods of facilitating mammalian cellular uptake of glycoproteins
    Patent number: 9347050
    Abstract: The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
    Type: Grant
    Filed: September 29, 2011
    Date of Patent: May 24, 2016
    Assignee: Oxyrane UK Limited
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken, Albena Vergilieva Valevska, Gwenda Noëlla Pynaert
  • MANNOSIDASES CAPABLE OF UNCAPPING MANNOSE-1-PHOSPHO-6-MANNOSE LINKAGES AND DEMANNOSYLATING PHOSPHORYLATED N-GLYCANS AND METHODS OF FACILITATING MAMMALIAN CELLULAR UPTAKE OF GLYCOPROTEINS
    Publication number: 20130267473
    Abstract: The invention provides mannosidases capable of uncapping mannose-1-phospho-6-mannose moieties and demannosylating phosphorylated N-glycans, methods of using such mannosidases, glycoproteins produced using the methods, as well as methods of facilitating mammalian cellular uptake of glycoproteins.
    Type: Application
    Filed: September 29, 2011
    Publication date: October 10, 2013
    Inventors: Kathleen Camilla Telesphore Alida Maria Piens, Wouter Vervecken, Albena Vergilieva Valevska, Gwenda Noella Pynaert