Patents by Inventor Albert A. Bowers

Albert A. Bowers has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • NUCLEIC ACID LIGAND CONJUGATES AND USE THEREOF FOR DELIVERY TO CELLS
    Publication number: 20230285579
    Abstract: The present invention relates to conjugated products comprising a ligand linked to a nucleic acid. The invention further relates to methods for delivering a nucleic acid to a cell and treating a disease using the conjugated products. The invention further relates to methods of increasing uptake of a nucleic acid by a cell comprising conjugating the nucleic acid to a ligand to form the conjugated product of the invention.
    Type: Application
    Filed: May 12, 2021
    Publication date: September 14, 2023
    Inventors: Chad Pecot, Salma H. Azam, Albert Bowers, Matthew Cyril Fleming
  • Method for preparing largazole analogs and uses thereof
    Patent number: 10676504
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: June 9, 2020
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Tenaya L. Newkirk, Albert A. Bowers, Jennifer Marie Guerra
  • Method for Preparing Largazole Analogs and Uses Thereof
    Publication number: 20180044376
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: March 3, 2016
    Publication date: February 15, 2018
    Inventors: Robert M. Williams, James E. Bradner, Dane Clausen, Olaf G. Wiest, Tenaya L. Newkirk, Albert A. Bowers, Jennifer Marie Guerra
  • Method for preparing largazole analogs and uses thereof
    Patent number: 9186402
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: July 17, 2013
    Date of Patent: November 17, 2015
    Assignees: Colorado State University Research University, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
  • Method for Preparing Largazole Analogs and Uses Thereof
    Publication number: 20140093449
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: July 17, 2013
    Publication date: April 3, 2014
    Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, UNIVERSITY OF NOTRE DAME DU LAC, DANA-FARBER CANCER INSTITUTE, INC.
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
  • Method for preparing largazole analogs and uses thereof
    Patent number: 8513290
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: June 7, 2012
    Date of Patent: August 20, 2013
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute, Inc., University of Notre Dame du Lac
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Olaf G. Wiest
  • Method for Preparing Largazole Analogs and Uses Thereof
    Publication number: 20120264794
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: June 7, 2012
    Publication date: October 18, 2012
    Applicants: DANA-FARBER CANCER INSTITUTE, INC., COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Ann E. Youngman
  • Method for preparing largazole analogs and uses thereof
    Patent number: 8217076
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Grant
    Filed: July 16, 2009
    Date of Patent: July 10, 2012
    Assignees: Colorado State University Research Foundation, Dana-Farber Cancer Institute
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk
  • Method for preparing largazole analogs and uses thereof
    Publication number: 20100029731
    Abstract: Analogs of largazole are described herein. Methods of treating cancer and blood disorders using largazole and largazole analogs and pharmaceutical compositions comprising the same are additionally described herein. Methods for preparing largazole analogs are likewise described.
    Type: Application
    Filed: July 16, 2009
    Publication date: February 4, 2010
    Applicants: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION, Dana-Farber Cancer Institute, Inc.
    Inventors: Robert M. Williams, James E. Bradner, Albert Bowers, Tenaya Newkirk, Ann E. Youngman
  • Multicomponent coupling and glycopeptide synthesis with cyclic thioanhydrides
    Publication number: 20090163697
    Abstract: Disclosed is a method of coupling an amino or hydroxyl compound with the amino portion of a sulfonamide via condensation with a cyclic thioanhydride. The reaction of cyclic thioanhydrides with amines affords amides functionalized with thioacids, which can be trapped in situ with preferably electron deficient arylsulfonamides. In this manner the cyclic thioanhydride serves as a linchpin in a three component coupling sequence.
    Type: Application
    Filed: December 19, 2008
    Publication date: June 25, 2009
    Inventors: David Crich, Albert A. Bowers
  • Determinate positioner assembly
    Patent number: 6195407
    Abstract: A determinate positioner assembly comprises a helical cam, such as a threaded lead screw, a follower element which continuously contacts the lead screw in a predetermined number of places for a determinate condition (neither over- nor underconstrained), an elastic member connecting the follower element to the leadscrew, and a driven element. The elastic member maintains continuous contact between the follower element and the cam, yet the combination of the elastic member and the follower element exert substantially zero net force on the cam in the x and y directions. The follower element is attached to the driven element with pivot structures which transmit axial movement from the follower element to the driven element and permit the follower element to “float” in the x and y directions while prohibiting its rotation about the x, y and z axes.
    Type: Grant
    Filed: April 21, 1999
    Date of Patent: February 27, 2001
    Assignee: Analogic Corporation
    Inventors: John McGregor Dobbs, Brian Michael McDermott, James Albert Bowers, Jr.