Abstract: A diagnostically useful carrier includes a peptide including the amino acid sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or a variant thereof. A kit, a composition, a detection method, use for detecting a neurological disease, a human autoantibody specifically binding to Drebrin and a therapeutic compound or combination for use in the treatment of a neurological use are also useful.

Abstract: A diagnostically useful carrier includes a peptide including the amino acid sequence set forth in SEQ ID NO: 1, SEQ ID NO: 2, SEQ ID NO: 3, SEQ ID NO: 4 or a variant thereof. A kit, a composition, a detection method, use for detecting a neurological disease, a human autoantibody specifically binding to Drebrin and a therapeutic compound or combination for use in the treatment of a neurological use are also useful.

Abstract: The present invention refers to a GPR101 inhibitor, antagonist or inverse agonist or inverse agonist for use in preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism. Further, the present invention provides a GPR101 agonist for use in preventive and/or therapeutic treatment of disorders selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion wherein to a subject GPR101 agonist is administered.

Abstract: The present invention refers to a GPR101 inhibitor, antagonist or inverse agonist or inverse agonist for use in preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism. Further, the present invention provides a GPR101 agonist for use in preventive and/or therapeutic treatment of disorders selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion wherein to a subject GPR101 agonist is administered.

Abstract: The present invention refers to a GPR101 inhibitor, antagonist or inverse agonist or inverse agonist for use in preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of acromegaly and gigantism wherein to a subject GPR101 inhibitor, antagonist or inverse agonist is administered. Further, the present invention provides a GPR101 agonist for use in preventive and/or therapeutic treatment of disorders selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion and to methods for preventive and/or therapeutic treatment of diseases selected from the group consisting of dwarfism, short stature, hypopituitarism and a disease of low levels of pituitary hormone secretion wherein to a subject GPR101 agonist is administered.

Abstract: A sanitary stand fitting for fixing in a receiving hole of a fitting support, such as that of a sanitary appliance such as a wash-stand or sink or the like, or other support plate with a fixing anchor movably supported on the fitting body, which anchor, when the fitting body is assembled, can be brought into a position flush with the receiving hole of the fitting support, and can be guided through the receiving hole and automatically assumes a locked position after passing through the receiving hole, and with a clamping device by means of which the fitting body and the fixing anchor, in its locked position, are clamped against each other, characterised in that the fixing anchor (12) is retained on the fitting body (10) by means of an elongated flexible spring (11) having a greater length than the material thickness of the fitting support (16), and in that a threaded rod (14), as a clamping device, can be passed through a hole (13) formed in the fitting body (10) and can be screwed into a threaded hole formed

Abstract: Described is a packaged hygiene product for receiving body fluids and/or excretions, wherein the hygiene product has a body side facing towards the body and a washing side facing away from the body and can be folded or rolled up for packaging, wherein an adhesive is disposed at least partially at the washing side and wherein there is provided a packaging material which has an inside facing towards the hygiene product and an outside facing away from the hygiene product, wherein the washing side of the hygiene product is fixed to the inside by means of the adhesive. The aim is to develop that hygiene product in such a way that on the one hand the fish mouth effect is avoided and on the other both the packaged hygiene product itself is cheaper to produce and also the machines for the production of the packaged hygiene products are simplified.

Abstract: An apparatus for producing hygiene products includes several stations (2) with at least partially differing machine components (3) and predominantly separate independent drives (4). The machine components (3) and the drives (4) are assembled together on carrier plates (9) to form assembly units, and are securely mountable in a machine frame, which includes vertical upright supports (18) and horizontal connecting struts (17, 19, 20). The assembly units are provided as small modules (10) assembled from the machine components (3), drives (4) and carrier plates (9), which in turn at least partially are assembled together to form large modules (12) in the manner of large assembly units, which further in turn are assembled and connected together to form the apparatus including the machine frame, the machine components (3), and their drives (4).

Abstract: In a method and an apparatus for manufacturing multi-layered hygiene products, a starting material web (2) is transported from one or more supply stations (4) to one or more processing stations (3) in which the starting material is cut, shaped, laminated, folded, etc. so as to form the finished hygiene products. The processing stations (3) are arranged on a processing plane (12), while the supply stations (4) are arranged on a supply plane (13), wherein these two planes are respective parallel vertical planes that are horizontally spaced apart from each other. The physical separation of the supply stations from the processing stations allows an effective noise shielding of the processing stations and the use of larger supply rolls in the supply stations, as well as improved accessibility of the equipment.

Abstract: A sanitary fitting including a fitting body with at least one supply channel and at least one discharge channel, at least one supply line which is flow-connected to the supply channel for providing flow connection to a supply network, a drain arm which is flow-connected to the discharge channel, at least one actuating element for adjusting the amount of flow and/or flow temperature, and a fastening element for fastening the fitting body to a base, the fastening element including at least one receiver for frictionally engaging the at least one supply thereby removably securing the fitting body to the base.

Abstract: A plaster guard for a concealed sanitary valve which can be controlled by means of a valve control element such as a valve spindle or a valve control disc. The plaster guard is equipped with a tool to operate the valve control element.

Abstract: A sanitary fitting with a cartridge, a mixer and a spout which is built integrally with a housing and can be swivelled around the mixer, whereby the housing glides on at least one sliding ring located in a groove provided in the mixer. The external dimensions of the fitting are kept as small as possible. The diameter of the mixer is smaller than the diameter of the cartridge and a spacer, preferably made of plastic, is placed between the cartridge and the mixer, whereby the spacer has on the side facing the cartridge at least the diameter of the cartridge. Alternatively or in addition, a washer can be inserted into the groove for the sliding ring to seal the mixer from the housing.

Abstract: A sanitary water fitting having a bearing ring arranged as a sliding bearing between the fitting body and the bearing sleeve. The bearing ring seals off a circling groove holding sealing rings from the bearing sleeve and is itself sealed off from the bearing sleeve by means of an external seal placed at the bearing ring. In its axial extension it borders a water passage opening which is between a circulating water channel and a swivel spout connection piece. The advantage of this invention is that the water flow in the circulating water channel and towards the swivel spout connection piece is controlled in such a way that the formation of lime deposits in the area of the sealing rings is considerably limited even after a relatively long period of operation, or even prevented completely.

Abstract: In a sanitary fitting with a cylindrical fitting body that can be mounted in a fixed position and has inlet and outlet channels and an outflow channel, with a cylindrical fitting sleeve that has a pivot arm with an outlet mouthpiece connected at the side and is pushed onto the body of the fitting, with a valve unit mounted on the body of the fitting and with a cap that covers the valve unit and is connected to the fitting sleeve, whereby sealing rings are provided between the fitting body and the fitting sleeve in the area of the outflow channel and in addition a lower bearing ring and an upper bearing ring are also provided, and whereby the bearing rings are preferably made of a plastic, especially a low-friction, low-wear plastic, and the lower bearing ring has an L-shaped cross section with a cylindrical section that forms a radial bearing and a projecting flange-like section that forms an axial bearing, and the upper bearing ring also has a cylindrical section that forms a radial bearing, the design of th

Abstract: A golf chipping and putting trainer having a substantially planar guide surface supported at the height of the wrists and hands of a golfer using the device in order to force the golfer to swing in a straight line while practicing chip shots and performing putting exercises.