Patents by Inventor Albert Bendelac

Albert Bendelac has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bacterial glycolipid activation of CD1d-restricted NKT cells
    Patent number: 9295722
    Abstract: Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.
    Type: Grant
    Filed: January 26, 2006
    Date of Patent: March 29, 2016
    Assignees: THE SCRIPPS RESEARCH INSTITUTE, THE UNIVERSITY OF CHICAGO, BRIGHAM YOUNG UNIVERSITY
    Inventors: Paul B. Savage, Albert Bendelac, Luc Teyton
  • 6?-amino-6?-deoxygalactosylceramides
    Patent number: 9045512
    Abstract: This invention relates to galactosylceramide compounds.
    Type: Grant
    Filed: May 20, 2013
    Date of Patent: June 2, 2015
    Assignees: The Scripps Research Institute, Brigham Young University, The University of Chicago
    Inventors: Paul B. Savage, Albert Bendelac, Luc Teyton
  • Adjuvants and methods of use
    Patent number: 8932594
    Abstract: Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed. Further provided are vaccine preparations comprising NKT cell agonist compounds.
    Type: Grant
    Filed: August 4, 2010
    Date of Patent: January 13, 2015
    Assignees: The Scripps Research Institute, The University of Chicago, Brigham Young University
    Inventors: Luc Teyton, Albert Bendelac, Paul B. Savage
  • Modified-galactosyl ceramides for staining and stimulating natural killer T cells
    Patent number: 8765692
    Abstract: Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells.
    Type: Grant
    Filed: June 22, 2012
    Date of Patent: July 1, 2014
    Assignees: The Scripps Research Institute, The University of Chicago, Bringham Young University
    Inventors: Paul B. Savage, Luc Teyton, Albert Bendelac
  • 6"-AMINO-6"-DEOXYGALACTOSYLCERAMIDES
    Publication number: 20140037693
    Abstract: This invention relates to galactosylceramide compounds.
    Type: Application
    Filed: May 20, 2013
    Publication date: February 6, 2014
    Applicants: The Scripps Research Institute, The University of Chicago, Brigham Young University
    Inventors: Paul B. SAVAGE, Albert BENDELAC, Luc TEYTON
  • Method of stimulating NKT with 6?-amino-6?-deoxygalactosylceramides
    Patent number: 8445272
    Abstract: This invention relates to galactosylceramide compounds.
    Type: Grant
    Filed: August 2, 2011
    Date of Patent: May 21, 2013
    Assignees: The Scripps Research Institute, The University of Chicago, Brigham Young University
    Inventors: Paul B. Savage, Albert Bendelac, Luc Teyton
  • MODIFIED-GALACTOSYL CERAMIDES FOR STAINING AND STIMULATING NATURAL KILLER T CELLS
    Publication number: 20120270815
    Abstract: Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells.
    Type: Application
    Filed: June 22, 2012
    Publication date: October 25, 2012
    Applicants: THE SCRIPPS RESEARCH INSTITUTE, THE UNIVERSITY OF CHICAGO, BRIGHAM YOUNG UNIVERSITY
    Inventors: Paul B. Savage, Luc Teyton, Albert Bendelac
  • Modified ?-galactosyl ceramides for staining and stimulating natural killer T cells
    Patent number: 8227581
    Abstract: Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells.
    Type: Grant
    Filed: April 9, 2007
    Date of Patent: July 24, 2012
    Assignees: The Scripps Research Institute, The University of Chicago, Brigham Young University
    Inventors: Paul B. Savage, Luc Teyton, Albert Bendelac
  • Methods of activating NKT cells
    Patent number: 7998739
    Abstract: Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided.
    Type: Grant
    Filed: September 2, 2005
    Date of Patent: August 16, 2011
    Assignees: The Scipps Research Institute, Brigham Young University, The University of Chicago
    Inventors: Albert Bendelac, Dapeng Zhou, Luc Teyton, Paul Savage
  • 6?-amino-6?-deoxygalactosylceramides
    Patent number: 7989423
    Abstract: This invention relates to galactosylceramide compounds.
    Type: Grant
    Filed: November 24, 2009
    Date of Patent: August 2, 2011
    Assignees: The Scripps Research Institute, Brigham Young University, The University of Chicago
    Inventors: Paul B. Savage, Albert Bendelac, Luc Teyton
  • METHODS OF ACTIVATING NKT CELLS
    Publication number: 20110082106
    Abstract: Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided.
    Type: Application
    Filed: October 11, 2010
    Publication date: April 7, 2011
    Applicants: The University of Chicago, Brigham Young University, The Scripps Research Institute
    Inventors: Albert Bendelac, Dapeng Zhou, Luc Teyton, Paul Savage
  • ADJUVANTS AND METHODS OF USE
    Publication number: 20110027323
    Abstract: Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed. Further provided are vaccine preparations comprising NKT cell agonist compounds.
    Type: Application
    Filed: August 4, 2010
    Publication date: February 3, 2011
    Applicants: The Scripps Research Institute, The University of Chicago, Brigham Young University
    Inventors: Luc Teyton, Albert Bendelac, Paul B. Savage
  • Adjuvants and methods of use
    Patent number: 7794722
    Abstract: Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed. Further provided are vaccine preparations comprising NKT cell agonist compounds.
    Type: Grant
    Filed: June 29, 2007
    Date of Patent: September 14, 2010
    Assignees: The Scripps Research Institute, The University of Chicago, Brigham Young University
    Inventors: Luc Teyton, Albert Bendelac, Paul B. Savage
  • 6"-AMINO-6"-DEOXYGALACTOSYLCERAMIDES
    Publication number: 20100137231
    Abstract: This invention relates to galactosylceramide compounds.
    Type: Application
    Filed: November 24, 2009
    Publication date: June 3, 2010
    Applicants: The Scripps Research Institute, Brigham Young University, The University of Chicago
    Inventors: Paul B. SAVAGE, Albert Bendelac, Luc Teyton
  • 6?-amino-6?-deoxygalactosylceramides
    Patent number: 7645873
    Abstract: This invention relates to galactosylceramide compounds.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: January 12, 2010
    Assignees: The Scripps Research Institute, Brighman Young University, The University of Chicago
    Inventors: Paul B. Savage, Albert Bendelac, Luc Teyton
  • MODIFIED ALPHA-GALACTOSYL CERAMIDES FOR STAINING AND STIMULATING NATURAL KILLER T CELLS
    Publication number: 20090047299
    Abstract: Modified glycolipid compounds are provided. Also disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, and methods suitable for labeling NKT cells.
    Type: Application
    Filed: April 9, 2007
    Publication date: February 19, 2009
    Inventors: Paul B. Savage, Luc Teyton, Albert Bendelac
  • Bacterial Glycolipid Activation of Cd1d-Restricted Nkt Cells
    Publication number: 20080279894
    Abstract: Disclosed are methods for activating an NKT cell, methods of stimulating an immune response in a subject, methods of improving vaccine efficacy, and methods of treating an infection. Also disclosed are methods of promoting tumor rejection, treating cancer, modulating autoimmunity and inhibiting allergen-induced hypersensitivity in subjects. The methods include contacting an NKT cell with a bacterial glycolipid complexed with a CD1 molecule to activate the NKT cell. The bacterial glycolipid may be derived from a member of the Class Alphaproteobacteria.
    Type: Application
    Filed: January 26, 2006
    Publication date: November 13, 2008
    Applicants: BRIGHAM YOUNG UNIVERSITY, THE UNIVERSITY OF CHICAGO, THE SCRIPPS RESEARCH INSTITUTE
    Inventors: Paul B. Savage, Albert Bendelac, Luc Teyton
  • ADJUVANTS AND METHODS OF USE
    Publication number: 20080095787
    Abstract: Compositions comprising NKT cell agonist compounds and a physiologically acceptable vehicle are provided. Methods of stimulating an NKT cell and enhancing an immune response are also disclosed. Further provided are vaccine preparations comprising NKT cell agonist compounds.
    Type: Application
    Filed: June 29, 2007
    Publication date: April 24, 2008
    Applicants: THE SCRIPPS RESEARCH INSTITUTE, THE UNIVERSITY OF CHICAGO, BRIGHAM YOUNG UNIVERSITY
    Inventors: Luc Teyton, Albert Bendelac, Paul Savage
  • 6"-Amino-6"-deoxygalactosylceramides
    Publication number: 20060264382
    Abstract: This invention relates to galactosylceramide compounds.
    Type: Application
    Filed: March 20, 2003
    Publication date: November 23, 2006
    Applicant: BRIGHAM YOUNG UNIVERSITY
    Inventors: Paul Savage, Albert Bendelac, Luc Teyton
  • Methods of activating NKT cells
    Publication number: 20060073118
    Abstract: Provided are methods of activating an NKT cell which include a step of contacting the NKT cell with a sufficient amount of isoglobotrihexosylceramide (iGb3) to induce secretion of a cytokine from the NKT cell, stimulate proliferation of the NKT cell or upregulate expression of a cell surface marker on the NKT cell. Methods of activating an NKT cell population in a subject are also provided.
    Type: Application
    Filed: September 2, 2005
    Publication date: April 6, 2006
    Applicants: The University of Chicago, The Scripps Research Institute, Brigham Young University
    Inventors: Albert Bendelac, Dapeng Zhou, Luc Teyton, Paul Savage