Patents by Inventor Albert C. Lardo

Albert C. Lardo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9737276
    Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.
    Type: Grant
    Filed: February 25, 2014
    Date of Patent: August 22, 2017
    Assignee: The Johns Hopkins University
    Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo
  • Publication number: 20170071675
    Abstract: The present invention is directed to a method for combining assessment of different factors of dyssynchrony into a comprehensive, non-invasive toolbox for treating patients with a CRT therapy device. The toolbox provides high spatial resolution, enabling assessment of regional function, as well as enabling derivation of global metrics to improve patient response and selection for CRT therapy. The method allows for quantitative assessment and estimation of mechanical contraction patterns, tissue viability, and venous anatomy from CT scans combined with electrical activation patterns from Body Surface Potential Mapping (BSPM). This multi-modal method is therefore capable of integrating electrical, mechanical, and structural information about cardiac structure and function in order to guide lead placement of CRT therapy devices. The method generates regional electro-mechanical properties overlaid with cardiac venous distribution and scar tissue.
    Type: Application
    Filed: May 12, 2015
    Publication date: March 16, 2017
    Inventors: Fady Dawoud, Karl H. Schuleri, Amir Pourmorteza, Albert C. Lardo, Elliot McVeigh
  • Patent number: 9320487
    Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.
    Type: Grant
    Filed: April 23, 2013
    Date of Patent: April 26, 2016
    Assignee: The Johns Hopkins University
    Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo
  • Patent number: 9265473
    Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of arterial stenosis in a selected portion of an arterial network. The method includes gathering patient-specific data related to concentration of a contrast agent within an arterial network using a coronary computed tomography angiography scan (CCTA). The data can be gathered under rest or stress conditions. Estimation of a loss coefficient (K) can be used to eliminate the need for data gathered under stress. The data is used to calculate a transluminal attenuation gradient (TAG). The data may be corrected for imaging artifacts at any stage of the analysis. TAFE is used to determine an estimate of flow velocity. Once velocity is determined, pressure gradient, coronary flow reserve, and/or fractional flow reserve can be determined through a variety of methods. These estimates can be used to estimate functional severity of stenosis.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: February 23, 2016
    Assignee: The Johns Hopkins University
    Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo
  • Patent number: 9031670
    Abstract: A shielded component or network for an active medical device (AMD) implantable lead includes an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to account for a shift in its inductance to a second inductive value when shielded.
    Type: Grant
    Filed: April 29, 2014
    Date of Patent: May 12, 2015
    Assignee: Greatbatch Ltd.
    Inventors: Warren S. Dabney, Robert Shawn Johnson, Holly Noelle Moschiano, Robert A. Stevenson, Henry R. Halperin, Albert C. Lardo, Kishore Kumar Kondabatni
  • Patent number: 8989870
    Abstract: An energy management system facilitates the transfer of high frequency energy coupled into an implanted lead at a selected RF frequency or frequency band, to an energy dissipating surface. This is accomplished by conductively coupling the implanted lead to the energy dissipating surface through an energy diversion circuit including one or more passive electronic network components whose impedance characteristics are at least partially tuned to the implanted lead's impedance characteristics.
    Type: Grant
    Filed: January 12, 2010
    Date of Patent: March 24, 2015
    Assignee: Greatbatch Ltd.
    Inventors: Robert Shawn Johnson, Warren S. Dabney, Robert A. Stevenson, Christopher Michael Williams, Holly Noelle Moschiano, Scott Brainard, Daniel Robert Kaiser, Henry R. Halperin, Albert C. Lardo
  • Patent number: 8918189
    Abstract: A shielded component or network for an active medical device (AMD) implantable lead includes (1) an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, (2) a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and (3) an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to a account for a shift in its inductance to a second inductive value when shielded.
    Type: Grant
    Filed: February 20, 2014
    Date of Patent: December 23, 2014
    Assignee: Greatbatch Ltd.
    Inventors: Warren S. Dabney, Robert Shawn Johnson, Holly Noelle Moschiano, Robert A. Stevenson, Henry R. Halperin, Albert C. Lardo, Kishore Kumar Kondabatni
  • Patent number: 8903505
    Abstract: A medical lead system includes at least one bandstop filter for attenuating current flow through the lead across a range of frequencies. The bandstop filter has an overall circuit Q wherein the resultant 3 dB bandwidth is at least 10 kHz. The values of capacitance and inductance of the bandstop filter are selected such that the bandstop filter is resonant at a selected center frequency or range of frequencies. Preferably, the bandstop filter has an overall circuit Q wherein the resultant 10 dB bandwidth is at least 10 kHz. Such bandstop filters are backwards compatible with known implantable deployment systems and extraction systems.
    Type: Grant
    Filed: October 19, 2011
    Date of Patent: December 2, 2014
    Assignee: Greatbatch Ltd.
    Inventors: Robert A. Stevenson, Henry R. Halperin, Albert C. Lardo, Warren S. Dabney, Kishore Kumar Kondabatni, Christine A. Frysz, Robert Shawn Johnson, Holly Noelle Moschiano, Barry C. Muffoletto
  • Patent number: 8855785
    Abstract: An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire and at least one non-linear circuit element switch for diverting energy in the implanted lead or the leadwire to the energy dissipating surface. In alternate configurations, the switch may be disposed so that it electrically opens the implanted lead or the leadwire when diverting energy to the energy dissipating surface. The non-linear circuit element switch is typically a PIN diode.
    Type: Grant
    Filed: June 10, 2014
    Date of Patent: October 7, 2014
    Assignee: Greatbatch Ltd.
    Inventors: Robert Shawn Johnson, Warren S. Dabney, Robert A. Stevenson, Christopher Michael Williams, Holly Noelle Moschiano, Scott Brainard, Daniel Robert Kaiser, Henry R. Halperin, Albert C. Lardo, Scott W. Kelley
  • Publication number: 20140296952
    Abstract: A shielded component or network for an active medical device (AMD) implantable lead includes an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to account for a shift in its inductance to a second inductive value when shielded.
    Type: Application
    Filed: April 29, 2014
    Publication date: October 2, 2014
    Applicant: Greatbatch Ltd.
    Inventors: Warren S. Dabney, Robert Shawn Johnson, Holly Noelle Moschiano, Robert A. Stevenson, Henry R. Halperin, Albert C. Lardo, Kishore Kumar Kondabatni
  • Patent number: 8849403
    Abstract: A lead extending exteriorly from an active implantable medical device (AIMD) is at least partially ensheathed within an electromagnetic interference (EMI) shield. The AIMD has a conductive equipotential surface to which the EMI shield may be conductively coupled. An impeding circuit may be provided for raising the high frequency impedance of the lead. An energy diversion circuit may also be provided for conductively coupling the lead to the EMI shield.
    Type: Grant
    Filed: May 26, 2010
    Date of Patent: September 30, 2014
    Assignee: Greatbatch Ltd.
    Inventors: Robert Shawn Johnson, Robert A. Stevenson, Warren S. Dabney, Holly Noelle Moschiano, Kishore Kumar Kondabatni, Neal Nesselbeck, Joseph Spaulding, Henry R. Halperin, Albert C. Lardo
  • Publication number: 20140288619
    Abstract: An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire, a diversion or diverter circuit associated with the energy dissipating surface, and at least one non-linear circuit element switch for diverting energy in the implanted lead or the leadwire through the diversion circuit to the energy dissipating surface. In alternate configurations, the switch may be disposed between the implanted lead or the leadwire and the diversion circuit, or disposed so that it electrically opens the implanted lead or the leadwire when diverting energy through the diversion circuit to the energy dissipating surface. The non-linear circuit element switch is typically a PIN diode. The diversion circuit may be either a high pass filter or a low pass filter.
    Type: Application
    Filed: June 10, 2014
    Publication date: September 25, 2014
    Inventors: Robert Shawn Johnson, Warren S. Dabney, Robert A. Stevenson, Christopher Michael Williams, Holly Noelle Moschiano, Scott Brainard, Daniel Robert Kaiser, Henry R. Halperin, Albert C. Lardo, Scott W. Kelley
  • Publication number: 20140243662
    Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of arterial stenosis in a selected portion of an arterial network. The method includes gathering patient-specific data related to concentration of a contrast agent within an arterial network using a coronary computed tomography angiography scan (CCTA). The data can be gathered under rest or stress conditions. Estimation of a loss coefficient (K) can be used to eliminate the need for data gathered under stress. The data is used to calculate a transluminal attenuation gradient (TAG). The data may be corrected for imaging artifacts at any stage of the analysis. TAFE is used to determine an estimate of flow velocity. Once velocity is determined, pressure gradient, coronary flow reserve, and/or fractional flow reserve can be determined through a variety of methods. These estimates can be used to estimate functional severity of stenosis.
    Type: Application
    Filed: March 11, 2014
    Publication date: August 28, 2014
    Applicant: The Johns Hopkins University
    Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo
  • Publication number: 20140187928
    Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.
    Type: Application
    Filed: February 25, 2014
    Publication date: July 3, 2014
    Applicant: The Johns Hopkins University
    Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo
  • Publication number: 20140180080
    Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transarterial attenuation gradient for the coronary artery of the patient. The patient specific transarterial attenuation gradient is compared to previously collected data to determine an estimate of a pressure gradient and/or fractional flow reserve (FFR) for the patient. As more data is collected, the data can be added to the database in order to increase the accuracy of future assessments. The database can also be enhanced by adding data generated by canonical models and mathematical analysis.
    Type: Application
    Filed: February 25, 2014
    Publication date: June 26, 2014
    Applicant: The Johns Hopkins University
    Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo, Parastou Eslami
  • Publication number: 20140172059
    Abstract: A shielded component or network for an active medical device (AMD) implantable lead includes (1) an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, (2) a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and (3) an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to a account for a shift in its inductance to a second inductive value when shielded.
    Type: Application
    Filed: February 20, 2014
    Publication date: June 19, 2014
    Applicant: Greatbatch Ltd.
    Inventors: Warren S. Dabney, Robert Shawn Johnson, Holly Noelle Moschiano, Robert A. Stevenson, Henry R. Halperin, Albert C. Lardo, Kishore Kumar Kondabatni
  • Patent number: 8751013
    Abstract: An energy management system that facilitates the transfer of high frequency energy induced on an implanted lead or a leadwire includes an energy dissipating surface associated with the implanted lead or the leadwire, a diversion or diverter circuit associated with the energy dissipating surface, and at least one non-linear circuit element switch for diverting energy in the implanted lead or the leadwire through the diversion circuit to the energy dissipating surface. In alternate configurations, the switch may be disposed between the implanted lead or the leadwire and the diversion circuit, or disposed so that it electrically opens the implanted lead or the leadwire when diverting energy through the diversion circuit to the energy dissipating surface. The non-linear circuit element switch is typically a PIN diode. The diversion circuit may be either a high pass filter or a low pass filter.
    Type: Grant
    Filed: May 17, 2013
    Date of Patent: June 10, 2014
    Assignee: Greatbatch Ltd.
    Inventors: Robert Shawn Johnson, Warren S. Dabney, Robert A. Stevenson, Christopher Michael Williams, Holly Noelle Moschiano, Scott Brainard, Daniel Robert Kaiser, Henry R. Halperin, Albert C. Lardo, Scott W. Kelley
  • Patent number: 8712544
    Abstract: A shielded component or network for an active medical device (AMD) implantable lead includes (1) an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, (2) a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and (3) an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to a account for a shift in its inductance to a second inductive value when shielded.
    Type: Grant
    Filed: April 11, 2013
    Date of Patent: April 29, 2014
    Assignee: Greatbatch Ltd.
    Inventors: Warren S. Dabney, Robert Shawn Johnson, Holly Noelle Moschiano, Robert A. Stevenson, Henry R. Halperin, Albert C. Lardo, Kishore Kumar Kondabatni
  • Publication number: 20140088414
    Abstract: An embodiment in accordance with the present invention provides a method for non-invasively determining the functional severity of coronary artery stenosis. The method includes gathering patient-specific data related to concentration of a contrast agent within a coronary artery of a patient using a coronary computed tomography angiography scan (CCTA). The patient-specific data is used to calculate a patient-specific transluminal attenuation gradient for the coronary artery of the patient. The patient specific transluminal attenuation gradient is used to determine an estimate of a coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and/or fractional flow reserve for the patient. Coronary flow velocity, pressure gradient, loss coefficient, coronary flow reserve, and fractional flow reserve can then be used to estimate the functional severity of coronary artery stenosis.
    Type: Application
    Filed: April 23, 2013
    Publication date: March 27, 2014
    Applicant: The Johns Hopkins University
    Inventors: Rajat Mittal, Albert C. Lardo, Jung Hee Seo
  • Patent number: 8670841
    Abstract: A shielded component or network for an active medical device (AMD) implantable lead includes (1) an implantable lead having a length extending from a proximal end to a distal end, all external of an AMD housing, (2) a passive component or network disposed somewhere along the length of the implantable lead, the passive component or network including at least one inductive component having a first inductive value, and (3) an electromagnetic shield substantially surrounding the inductive component or the passive network. The first inductive value of the inductive component is adjusted to a account for a shift in its inductance to a second inductive value when shielded.
    Type: Grant
    Filed: April 10, 2013
    Date of Patent: March 11, 2014
    Assignee: Greatbatch Ltd.
    Inventors: Warren S. Dabney, Robert Shawn Johnson, Holly Noelle Moschiano, Robert A. Stevenson, Henry R. Halperin, Albert C. Lardo, Kishore Kumar Kondabatni