Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using these compositions as a vaccine for treatment of an infectious disease are also provided.

Abstract: Provided herein are dried compositions and methods for preparing such compositions for use in delivery of a nucleic acid to a subject. The dried composition may comprise a lipid carrier, wherein the lipid carrier is a nanoemulsion comprising a hydrophobic core, optionally one or more inorganic nanoparticles and one or more lipids, one or more nucleic acid, and at least one cryoprotectant. Methods of using these dried compositions for treatment are also provided.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided.

Abstract: Provided herein are dried compositions and methods for preparing such compositions for use in delivery of a nucleic acid to a subject. The dried composition may comprise a lipid carrier, wherein the lipid carrier is a nanoemulsion comprising a hydrophobic core, optionally one or more inorganic nanoparticles and one or more lipids, one or more nucleic acid, and at least one cryoprotectant. Methods of using these dried compositions for treatment are also provided.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using these compositions as a vaccine for treatment of an infectious disease are also provided.

Abstract: The disclosure provides nanoparticle compositions and methods of making and using the same to deliver a bioactive agent such as a nucleic acid which is a PRR agonist to a subject. Various nanoparticle carriers are described. In some instances, the nanoparticle component may include a hydrophobic core having an inorganic particle, and optionally a membrane having a cationic lipid. Various PRR agonists are described. In some instances, the PRR agonist is a RIG-I agonist or a TLR3 agonist.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Methods of using the compositions as a COVID-19 vaccine for the treatment of a coronavirus infection are also provided.

Abstract: Provided herein are dried compositions and methods for preparing such compositions for use in delivery of a nucleic acid to a subject. The dried composition may comprise a lipid carrier, wherein the lipid carrier is a nanoemulsion comprising a hydrophobic core, optionally one or more inorganic nanoparticles and one or more lipids, one or more nucleic acid, and at least one cryoprotectant. Methods of using these dried compositions for treatment are also provided.

Abstract: The disclosure provides compositions, methods of treatment, and methods of making and using compositions to deliver a nucleic acid to a subject. Compositions described herein include lipid carriers, optionally including an inorganic particle, capable of admixing with nucleic acids. Nucleic acids provided herein include those encoding for cancer antigens (full length proteins or fragments) as well as antibodies. Methods of using the compositions as a therapeutic vaccine for the treatment of a cancer are also provided.

Abstract: A hoisting apparatus that is operable to lift objects from a transport vehicle and further provide positioning thereof in alternate location wherein the present invention provides load leveling and balancing of the object while suspended. The present invention includes a housing that is suspendedly mounted to a crane lifting block. The housing includes an exterior wall having a top and a bottom and further including an interior volume with an opening at the bottom substantially the diameter of the housing. The housing has mounted therein four winches wherein each of the four winches is independently operated so as to separately control the length thereof. A center attachment member is present that is configured to secure the hoisting apparatus to the lifting block of a crane. Securing members are operably coupled to the center attachment member and are equidistantly distributed around the circumference of the housing.

Abstract: An in-floor electrical fitting includes a lower body, an upper body detachably connected to the lower body, and at least one detachable retention clip movable between a first position in which a portion of the at least one detachable retention clip extends outwardly past a periphery of the body and a second position in which the portion of the at least one detachable retention clip is moved inward from the periphery of the body. An angular position of the upper body may be reconfigurable relative to the lower body into at least two different orientations.

Abstract: An in-floor electrical fitting includes a lower body, an upper body detachably connected to the lower body, and at least one detachable retention clip movable between a first position in which a portion of the at least one detachable retention clip extends outwardly past a periphery of the body and a second position in which the portion of the at least one detachable retention clip is moved inward from the periphery of the body. An angular position of the upper body may be reconfigurable relative to the lower body into at least two different orientations.

Abstract: A circuit board for an electrical connector includes a plurality of pairs of first contacts disposed at a first end of the circuit board and a plurality of pairs of second contacts disposed at a second end. Each first contact is connected to a second contact by first conductors disposed at least on a first side of the circuit board. Second conductors are disposed on the circuit board and connected to a first contact or a second contact. A second conductor is associated with a first contact of each pair of first contacts and a second contact of each pair of second contacts. Adjacent second conductors of the first contacts include segments at least partially parallel to each other, forming first coupling regions. Adjacent second conductors of the second contacts include segments at least partially parallel to each other, forming second coupling regions.

Abstract: The invention relates to a circuit board (100) for an electrical connector (400), comprising a plurality of pairs of first contacts (110) disposed at a first end (112) of the circuit board (100) and a plurality of pairs of second contacts (120) disposed at a second end (122), wherein each first contact (110) is connected to a second contact (120) by way of first conductors (115.1-115.8), wherein the first conductors (115.1-115.8) are disposed at least on a first side (104) of the circuit board (110), wherein second conductors (125.2, 125.4, 125.6, 125.8; 135.1, 135.3, 135.5, 135.7) are disposed on a further side (106) of the circuit board (100) and connected to a first contact (110) or a second contact (120), wherein a second conductor (135.1, 135.3, 135.5, 135.7) is associated with a first contact (110.1, 110.3, 110.5, 110.7) of each pair of first contacts (110), wherein the adjacent second conductors (135.1, 135.3, 135.5, 135.

Abstract: The invention relates to an image forming media composition including an infrared reflecting pigment. The infrared reflecting pigment may be one that substantially absorbs light in the visible spectrum of about 400-700 nanometers and reflects greater than about 5.0% of light within the wavelength of about 700-2500 nanometers. The infrared reflecting pigment may therefore be combined with pigments such as carbon black in a toner formulation and provide the ability to control toner thickness level within a device such as a toner patch sensor.

Abstract: Control circuitry associated with an electrophotographic imaging device is adapted to operate in conjunction with a sensor to adjust operating parameters, including an imaging power. The sensor detects a reflectivity of a developed image and the control circuitry uses this detected information and information related to reflectivity of the underlying surface and the developing toner to determine whether the developed image is produced as desired. The control circuitry adjusts imaging power in response to a comparison between the detected reflectivity and a target reflectivity. In one embodiment, a predetermined halftone pattern is developed over a range of imaging powers and an optimum operating point is determined from the iterations. A predictive model may be generated based on many data points to select imaging power based on optimized surface potentials.

Abstract: Control circuitry associated with an electrophotographic imaging device is adapted to operate in conjunction with a sensor to adjust a difference in electrical bias between a photoconductive surface and an associated roller. The sensor detects a reflectance or luminosity of a developed image and the control circuitry uses this detected information and information related to reflectance or luminosity of the underlying surface and the developing toner to determine whether the developed image is produced as desired. The control circuitry adjusts the difference in electrical bias between the photoconductive surface and an associated roller in response to a comparison between the detected and desired images. In one embodiment, a predetermined test pattern is developed over a range of electrical bias differences and an optimum operating point is determined from the iterations.

Abstract: A temperature compensated doctor blade system is disclosed for controlling the amount of liquid on a substrate. Variation in temperature is found to cause wide variation in liquid viscosity which affects doctor blade pressure requirements. An expandable chamber containing a temperature responsive fluid is used to control the pressure applied to a flexible doctor blade.