Patents by Inventor Albert Cheng

Albert Cheng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240385671
    Abstract: Methods and other embodiments are described for enabling clock waveform synthesis for, in some embodiments, tensor or graphical processors that enable shorter runtime latency, higher computational job throughput, more efficient power management, and a lower implementation cost than alternative clock waveform methods. This Abstract and the independent Claims are concise signifiers of embodiments of the claimed inventions. The Abstract does not limit the scope of the claimed inventions.
    Type: Application
    Filed: October 31, 2023
    Publication date: November 21, 2024
    Inventors: James David Sproch, Albert Cheng, Michael Bye
  • Publication number: 20240192855
    Abstract: When reading and writing DRAM (dynamic random-access memory), the latency and bandwidth is often unpredictable with large variations. One reason is because all the DRAM memory banks require periodic refreshes and maintenance cycles that interrupt these accesses. DRAM refresh and maintenance cycles are synchronized with the read/write accesses in a mutually exclusive manner, hence, preventing the accesses from being interfered with by a refresh or maintenance cycle resulting in predictable latency and bandwidth performance during read/write operations.
    Type: Application
    Filed: December 13, 2023
    Publication date: June 13, 2024
    Inventors: Albert Cheng, Michael Bye, Rahul Shah
  • Publication number: 20240141411
    Abstract: Provided herein, in some aspects, is a multiplex RNA targeting system that enables live cell imaging and/or modification of multiple RNA targets. Specifically, the disclosure provides a method of live cell imaging of ribonucleic acid (RNA), or targeting RNA in a live cell, comprising: (a) delivering to a cell an RNA-editing complex that comprises a catalytically inactive Cas13 (dCas13) nuclease, a Cas 13 guide RNA (gRNA) comprising an RNA aptamer sequence, and a detectable molecule linked to an RNA-binding domain (RBD), or an RNA effector molecule linked to an RBD sequence that specifically binds to the RNA aptamer sequence; and (b) imaging the detectable molecule or RNA aptamer and RBD binding.
    Type: Application
    Filed: March 3, 2022
    Publication date: May 2, 2024
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Zukai Liu
  • Publication number: 20240132557
    Abstract: Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, inter alia, useful for modulating the expression of a target gene, or to create a gene regulatory network.
    Type: Application
    Filed: August 23, 2023
    Publication date: April 25, 2024
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Aziz Taghbalout, Nathaniel Jillette
  • Patent number: 11792114
    Abstract: A network interface controller (NIC) capable of efficient management of non-idempotent operations is provided. The NIC can be equipped with a network interface, storage management logic block, and an operation management logic block. During operation, the network interface can receive a request for an operation from a remote device. The storage management logic block can store, in a local data structure, outcome of operations executed by the NIC. The operation management logic block can determine whether the NIC has previously executed the operation. If the NIC has previously executed the operation, the operation management logic block can obtain an outcome of the operation from the data structure and generate a response comprising the obtained outcome for responding to the request.
    Type: Grant
    Filed: March 23, 2020
    Date of Patent: October 17, 2023
    Assignee: Hewlett Packard Enterprise Development LP
    Inventors: Duncan Roweth, Robert L. Alverson, Albert Cheng, Timothy J. Johnson
  • Patent number: 11780895
    Abstract: Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: October 10, 2023
    Assignee: The Jackson Laboratory
    Inventors: Albert Cheng, Aziz Taghbalout, Nathaniel Jillette
  • Publication number: 20230295615
    Abstract: The invention described herein provides compositions and reagents for integrating large sequences (e.g., 150 bp or more) into a selected target DNA sequence via prime editing.
    Type: Application
    Filed: August 6, 2021
    Publication date: September 21, 2023
    Inventors: Albert Cheng, Nathaniel Jillette
  • Publication number: 20230114264
    Abstract: The present disclosure provides methods of inducing EBV early lytic cycle genes with high specificity. These methods slow or stop cancer cell growth in vitro and in vivo.
    Type: Application
    Filed: February 26, 2021
    Publication date: April 13, 2023
    Applicants: The Jackson Laboratory, The Chinese University of Hong Kong
    Inventors: Albert Cheng, Kwok Wai Lo, Pok Man Tom Hau, Man Wu
  • Publication number: 20230071712
    Abstract: The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.
    Type: Application
    Filed: July 28, 2022
    Publication date: March 9, 2023
    Applicant: The Jackson Laboratory
    Inventors: Haoyi Wang, Albert Cheng, Nathaniel Jillette
  • Publication number: 20220333172
    Abstract: Provided herein are methods of imaging non-repetitive genomic loci using unique guide ribonucleic acids (gRNAs), an RNA-guided nuclease, and a detectable conjugate.
    Type: Application
    Filed: August 13, 2020
    Publication date: October 20, 2022
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Patricia Clow
  • Patent number: 11434484
    Abstract: The invention described herein provides compositions and reagents for assembling a tripartite complex at a specific location of a target DNA. The invention also provides methods for using the complex to, for example, label a specific genomic locus, to regulate the expression of a target gene, or to create a gene regulatory network.
    Type: Grant
    Filed: September 13, 2017
    Date of Patent: September 6, 2022
    Assignee: The Jackson Laboratory
    Inventors: Haoyi Wang, Albert Cheng, Nathaniel Jillette
  • Publication number: 20220200897
    Abstract: A network interface controller (NIC) capable of efficient management of non-idempotent operations is provided. The NIC can be equipped with a network interface, storage management logic block, and an operation management logic block. During operation, the network interface can receive a request for an operation from a remote device. The storage management logic block can store, in a local data structure, outcome of operations executed by the NIC. The operation management logic block can determine whether the NIC has previously executed the operation. If the NIC has previously executed the operation, the operation management logic block can obtain an outcome of the operation from the data structure and generate a response comprising the obtained outcome for responding to the request.
    Type: Application
    Filed: March 23, 2020
    Publication date: June 23, 2022
    Inventors: Duncan Roweth, Robert L. Alverson, Albert Cheng, Timothy J. Johnson
  • Publication number: 20210388351
    Abstract: Provided herein, in some aspects, are compositions and methods for artificially modulating alternative splicing, for example, inducing exon inclusion and/or exon exclusion events. In some embodiments, a catalytically inactive programmable nuclease, such as dCasRx, is fused to an RNA-binding protein (or fragment or isoform thereof) and, when guided to a target of interest by a specific guide RNA (gRNA), can regulate alternative splicing in eukaryotic cells.
    Type: Application
    Filed: September 27, 2019
    Publication date: December 16, 2021
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Nathaniel Jillette
  • Patent number: 11166064
    Abstract: There is provided a system and method for the synchronizing on-air commercial programming with interactive applications, providing interactive content synchronized with on-air television programming. There is provided a system comprising a client device with a display device and an input device and running a synchronization application. The client device receives digital data transmitted from a server, and transmits user feedback information generated from user interactions with the digital data back to the server. The digital data are interactive advertisements, such as online social games, that increase users' awareness of the advertised products or messages. The digital data are delivered to the user's client device in synchronization with the broadcasting of on-air television commercials.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: November 2, 2021
    Assignee: Disney Enterprises, Inc.
    Inventor: Albert Cheng
  • Publication number: 20210189485
    Abstract: The present disclosure, in some embodiments, provides sequence detection systems (sequence detectors) for the detection of specific nucleotides sequences present in the genome of live cells (e.g., single live cells) to achieve, for example, in vivo and in situ imaging, cell selection, and/or cell ablation.
    Type: Application
    Filed: November 6, 2018
    Publication date: June 24, 2021
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Aziz Taghbalout, Nathaniel Lee Jillette
  • Publication number: 20200263197
    Abstract: The present disclosure provides a split intein selectable marker system for the production and selection of transgenic cells.
    Type: Application
    Filed: October 11, 2018
    Publication date: August 20, 2020
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Nathaniel Jillette, Menghan Du
  • Publication number: 20200071369
    Abstract: Provided herein are, inter alia, compositions and methods for demethylating and methylating a target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
    Type: Application
    Filed: September 13, 2017
    Publication date: March 5, 2020
    Applicant: The Jackson Laboratory
    Inventor: Albert Cheng
  • Patent number: 10469380
    Abstract: A multiprocessor computer system comprises a dragonfly processor interconnect network that comprises a plurality of processor nodes and a plurality of routers. The routers are operable to route data by selecting from among a plurality of network paths from a target node to a destination node in the dragonfly network based on one or more routing tables.
    Type: Grant
    Filed: March 7, 2016
    Date of Patent: November 5, 2019
    Assignee: Intel Corporation
    Inventors: Mike Parker, Steve Scott, Albert Cheng, Robert Alverson
  • Publication number: 20190218261
    Abstract: Provided herein are, inter alia, compositions and methods for the delivery of enhanced demethylation activity to target DNA sequences in a mammalian cell. The compositions and methods are, useful for activity modulation of a targeted gene, or to create a gene regulatory network.
    Type: Application
    Filed: September 13, 2017
    Publication date: July 18, 2019
    Applicant: The Jackson Laboratory
    Inventors: Albert Cheng, Aziz Taghbalout, Nathaniel Jillette
  • Patent number: 10230665
    Abstract: Methods, apparatus, and systems for implementing hierarchical and lossless packet preemption and interleaving to reduce latency jitter in flow-controller packet-based networks. Fabric packets are divided into a plurality of data units, with data units for different fabric packets buffered in separate buffers. Data units are pulled from the buffers and added to a transmit stream in which groups of data units are interleaved. Upon receipt by a receiver, the groups of data units are separated out and buffered in separate buffers under which data units for the same fabric packets are grouped together. In one aspect, each buffer is associated with a respective virtual lane (VL), and the fabric packets are effectively transferred over fabric links using virtual lanes. VLs may have different levels of priority under which data units for fabric packets in higher-priority VLs may preempt fabric packets in lower-priority VLs.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: March 12, 2019
    Assignee: Intel Corporation
    Inventors: Thomas D. Lovett, Albert Cheng, Mark S. Birrittella, James Kunz, Todd Rimmer