Abstract: Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion.

Abstract: Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion.

Abstract: Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion. The protein portion includes at least a portion of a globular head, and at least a portion of at least one secondary structure having at least one ?-sheet at a bottom of the globular head that causes the globular head to essentially retain its tertiary structure. The protein portion made by the methods of the invention lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. A nucleic acid sequence encoding the protein portion is transformed into a prokaryotic host cell.

Abstract: Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion. The protein portion includes at least a portion of a globular head, and at least a portion of at least one secondary structure having at least one ?-sheet at a bottom of the globular head that causes the globular head to essentially retain its tertiary structure. The protein portion made by the methods of the invention lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. A nucleic acid sequence encoding the protein portion is transformed into a prokaryotic host cell.

Abstract: Methods of making a protein that stimulates a protective immune response in a subject include separating a portion of a protein from a naturally occurring influenza viral hemagglutinin to form a protein portion.

Abstract: Methods that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a transmembrane domain, a cytoplasmic domain and an HA2 subunit. Compositions administered to the subject can further include a carrier and can be administered in single or multiple doses.

Abstract: Compositions that include at least one protein that activates a Toll-like Receptor and includes at least a portion of at least one Toll-like Receptor agonist and at least a portion of at least one papillomavirus suppressor binding protein, papillomavirus transforming protein and papillomavirus capsid protein can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can further include an adjuvant and a carrier protein.

Abstract: Methods of making and compositions that stimulate a protective immune response in a subject include a portion of a protein from a naturally occurring viral hemagglutinin, wherein the protein portion includes at least a portion of a globular head and at least a portion of at least one secondary structure that causes the globular head to essentially retain its tertiary structure, and wherein the protein portion lacks a membrane fusion domain, a transmembrane domain and a cytoplasmic domain. Compositions can further include a Toll-like Receptor agonist and a carrier protein.

Abstract: Compositions comprise a flagellin component that is at least a portion of a flagellin, wherein the flagellin component includes at least one cysteine residue and whereby the flagellin component activates a Toll-like Receptor 5. Compositions can further include an antigen, such as an influenza antigen. The compositions are used to stimulate an immune response and a protective immune response in a subject.

Abstract: Compositions that include at least one protein that activates a Toll-like Receptor and includes at least a portion of at least one Toll-like Receptor agonist and at least a portion of at least one papillomavirus suppressor binding protein, papillomavirus transforming protein and papillomavirus capsid protein can be employed in methods that stimulate an immune response in a subject, in particular, a protective immune response in a subject. Compositions can further include an adjuvant and a carrier protein.

Abstract: Compositions, fusion proteins and polypeptides comprise at least one pathogen-associated molecular pattern and at least a portion of at least one integral membrane protein of an influenza viral antigen. The compositions, fusion proteins and polypeptides are used to stimulate an immune response in a subject.

Abstract: This invention relates to a method for separating glycosylated prolactin from non-glycosylated prolactin.

Abstract: A heated railway tank car includes heating conduits arranged on the tank and filled with a heating fluid and coupled to an electrically driven pump and heat exchanger in a closed-loop system for heating and continuously recirculating the heating fluid through the conduit. The tank car is adapted to be electrically interconnected with adjacent cars and the electric power may be provided from the locomotive, from an axle generator and alternator combination on the tank car, or from rechargeable batteries on the tank car charged by either terminal facilities or axle-mounted or locomotive-mounted generator means.

Abstract: A railway train includes a plurality of interconnected tank cars, each car comprising a tank provided with two lading conduits in the top thereof extending thereinto for communication with the interior thereof and each having an outer end extending above the tank, and toward the adjacent end thereof, the lading conduits of adjacent cars being interconnected by flexible connecting conduits. A crane is pivotally mounted on the top of one of the lading conduits on each car for maintaining the associated flexible connecting conduit at an elevation higher than that of the associated conduit coupling means to cause drainage of all the lading from the flexible conduit into the associated tanks.

Abstract: A novel hopper vehicle, illustratively a freight hopper car, has a floor with two longitudinal hoppers and a pair of side-opening doors on opposite sides of the center line of the vehicle. Each door provides a part of one of the hoppers and is pivotally mounted on a side sill of the vehicle. Preferably each door is a wrap-around door to provide also a lower part of a side of the body of the vehicle and its pivotal mounting is on an intermediate side sill that extends between the sloping end walls of the body of the vehicle at an intermediate elevation. The body of the vehicle has fixed side walls. For the central portion of the floor of the car body there is a longitudinally-extending, inverted V-shaped panel that is mounted above the intermediate portion of the center sill of the car and that provides by its sloping walls the other part of the hoppers. In the construction with wrap-around doors the fixed side walls form only a part of the sides of the body.