Patents by Inventor Albert J. R. HECK

Albert J. R. HECK has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Middle Down Antibody Characterization
    Publication number: 20230221333
    Abstract: This disclosure relates to new methods for antibody characterization sequencing, such as middle down antibody characterization and sequencing, for example, for de novo antibody sequencing, identifying known antibodies in a sample, or verifying the sequence of antibodies in a sample. In some embodiments, the methods involve exposing antibodies to cathepsin D, cathepsin L, and/or cathepsin D and L, followed by mass spectrometry and sequence identification and deconvolution.
    Type: Application
    Filed: January 17, 2023
    Publication date: July 13, 2023
    Applicants: Genentech, Inc., Universiteit Utrecht Holding B.V.
    Inventors: Wendy Noel Sandoval, Tomislav Caval, Albert J.R. Heck, Elizabeth Sara Hecht
  • Method for determining the structure of a macromolecular assembly
    Patent number: 10373817
    Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detecting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.
    Type: Grant
    Filed: July 23, 2018
    Date of Patent: August 6, 2019
    Assignees: Thermo Fisher Scientific (Bremen) GmbH, Universiteit Maastricht, Universiteit Ultrecht Holding B.V.
    Inventors: Alexander Alekseevich Makarov, Ronald M. A. Heeren, Albert J. R. Heck
  • Method for Determining the Structure of a Macromolecular Assembly
    Publication number: 20190051507
    Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detecting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.
    Type: Application
    Filed: July 23, 2018
    Publication date: February 14, 2019
    Inventors: Alexander Alekseevich MAKAROV, Ronald M. A. HEEREN, Albert J. R. HECK
  • Method for determining the structure of a macromolecular assembly
    Patent number: 10032618
    Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detesting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.
    Type: Grant
    Filed: December 9, 2015
    Date of Patent: July 24, 2018
    Assignees: Thermo Fisher Scientific (Bremen) GmbH, Universiteit Maastricht, Universitiet Utrecht Holding B.V.
    Inventors: Alexander Alekseevich Makarov, Ronald M. A. Heeren, Albert J. R. Heck
  • Method for Determining the Structure of a Macromolecular Assembly
    Publication number: 20170345635
    Abstract: A method of determining the structure of a macromolecular assembly (MMA) comprises the steps of (a) generating precursor ions of an MMA species to be investigated; (b) transporting the MMA precursor ions to a fragmentation zone; (c) carrying out pulsed fragmentation of the MMA precursor ions in the fragmentation zone; (d) for a first plurality of MMA precursor ions, detesting both a spatial distribution of the resultant MMA fragment ions, and an m/z distribution of the MMA fragment ions; (e) analyzing the spatial and m/z distributions of fragment ions formed from the said first plurality of precursor ions of the MMA species to be investigated, to determine the relative positions of those fragment ions within the structure of the precursor MMA; and (f) reconstructing the three dimensional (3D) structure of the MMA from the analysis of the spatial and m/z distributions of fragment ions.
    Type: Application
    Filed: December 9, 2015
    Publication date: November 30, 2017
    Inventors: Alexander Alekseevich MAKAROV, Ronald M. A. HEEREN, Albert J. R. HECK