Patents by Inventor Albert J. T. Millis

Albert J. T. Millis has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Aptamer modulators of complement protein C3 and biologically active proteolytic products thereof
    Patent number: 8927509
    Abstract: This invention relates to nucleic acid aptamers that recognize and bind the complement protein C3 or its biologically active proteolytic products and methods of their use. Particularly preferred are bi-functional aptamer construct that binding specifically with C3b or iC3b, and another target protein. Use of these molecular constructs for commandeering the opsonization process is also described herein.
    Type: Grant
    Filed: May 20, 2009
    Date of Patent: January 6, 2015
    Assignee: The Research Foundation of State University of New York
    Inventors: Hua Shi, Albert J. T. Millis, Kimi Nishikawa, Prabhat Kumar Mallik
  • APTAMER MODULATORS OF COMPLEMENT PROTEIN C3 AND BIOLOGICALLY ACTIVE PROTEOLYTIC PRODUCTS THEREOF
    Publication number: 20120141382
    Abstract: This invention relates to nucleic acid aptamers that recognize and bind the complement protein C3 or its biologically active proteolytic products and methods of their use. Particularly preferred are bi-functional aptamer construct that binding specifically with C3b or iC3b, and another target protein. Use of these molecular constructs for commandeering the opsonization process is also described herein.
    Type: Application
    Filed: May 20, 2009
    Publication date: June 7, 2012
    Applicant: Research Foundation of State University of New York at Albany
    Inventors: Hua Shi, Albert J.T. Millis, Kimi Nishikawa, Prabhat Kumar Mallik
  • Compositions and methods for altering cell migration
    Publication number: 20030162702
    Abstract: The invention relates generally to compositions useful in altering the migration and/or proliferative activity of cells and to methods of using them. Reagents that can regulate cell migration and reorganization are useful in managing diseases in which cell migration and tissue remodeling play a role, including inhibiting vascular stenosis and restenosis that can result from endothelial injury. Migration-altering compositions include the proteins clusterin and gp38k and fragments thereof which retain the migration-altering activity, peptides derived from the proteins which possess the migration-altering activity, polyclonal, monoclonal and recombinant humanized antibodies directed against the proteins and fragments thereof and anti-sense oligonucleotides capable of binding clusterin and gp38k mRNAs.
    Type: Application
    Filed: October 15, 2002
    Publication date: August 28, 2003
    Applicant: The Research Foundation of State University of New York
    Inventor: Albert J.T. Millis
  • Compositions and methods for altering cell migration
    Patent number: 6464975
    Abstract: The invention relates generally to compositions useful in altering the migration and/or proliferative activity of cells and to methods of using them. Reagents that can regulate cell migration and reorganization are useful in managing diseases in which cell migration and tissue remodeling play a role, including inhibiting vascular stenosis and restenosis that can result from endothelial injury. Migration-altering compositions include the proteins clusterin and gp38k and fragments thereof which retain the migration-altering activity, peptides derived from the proteins which possess the migration-altering activity, polyclonal, monoclonal and recombinant humanized antibodies directed against the proteins and fragments thereof and anti-sense oligonucleotides capable of binding clusterin and gp38k mRNAs.
    Type: Grant
    Filed: December 10, 1999
    Date of Patent: October 15, 2002
    Assignee: The Research Foundation of State University of New York
    Inventor: Albert J. T. Millis
  • COMPOSITIONS AND METHODS FOR ALTERING CELL MIGRATION
    Publication number: 20020136716
    Abstract: The invention relates generally to compositions useful in altering the migration and/or proliferative activity of cells and to methods of using them. Reagents that can regulate cell migration and reorganization are useful in managing diseases in which cell migration and tissue remodeling play a role, including inhibiting vascular stenosis and restenosis that can result from endothelial injury. Migration-altering compositions include the proteins clusterin and gp38k and fragments thereof which retain the migration-altering activity, peptides derived from the proteins which possess the migration-altering activity, polyclonal, monoclonal and recombinant humanized antibodies directed against the proteins and fragments thereof and anti-sense oligonucleotides capable of binding clusterin and gp38k mRNAs.
    Type: Application
    Filed: December 10, 1999
    Publication date: September 26, 2002
    Inventor: ALBERT J. T. MILLIS