Abstract: Disclosed is a method of preparing diroximel fumarate represented by the following structural formula (I) The method comprises reacting ethy lene carbonate with succinimide to form a hydroxyethyl succinimide intermediate; and reacting the intermediate with monomethyl fumarate to form the product compound.

Abstract: In some aspects, a computing system may use machine learning to determine whether a control is faulty or generate recommendations to make a modification to a control. may identify a portion of problematic computer code that implements the faulty control through the use of machine learning. A computing system may use machine learning to generate embeddings that map incident data and control data (e.g., computer-readable code of a control) to the same vector space. Further, a computing system may use a weighting mechanism that may be used to weight each sample used to train a machine learning model, which may allow a model to train more efficiently.

Abstract: This invention provides lipid/dendrimer systems that can deliver therapeutic molecules such as nucleic acids to mammalian cells, and to the human and animal body. For instance, the invention provides systems that enable effective delivery of nucleic acids to the lymphoid organs, skeletal muscle, brain and adipose tissues, as well as to tumour tissue, liver and lungs. Delivery of DNA and RNA is provided. In particular, the systems of the invention can deliver of mRNA.

Abstract: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.

Abstract: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.

Abstract: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.

Abstract: The present invention is related to an improved process for the preparation of amino-substituted 4,5,6,7-tetrahydrobenzothiazole compounds of formula I, such as the compound 2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention further relates to an improved synthesis of (R)-2-amino-4,5,6,7-tetrahydro-6-(n-propylamino)benzothiazole. The invention also relates to the methods and intermediates associated with the synthetic process.

Abstract: Methods and systems may include high speed camera to capture a video of a display output, a robotic arm to interact with a device, a processor, and a computer readable storage medium having a set of instructions. If executed by the processor, the instructions cause the system to identify one or more user experience characteristics based on the captured video, and generate a report based on the one or more user experience characteristics. The report may include a perceptional model score that is generated based on the user experience characteristics as well as other parameters. The user experience characteristics could include response time, frame rate and run time characteristics.

Abstract: An architectural panel includes a substantially rectangular prismatic main body cast from lightweight concrete that has first and second major faces which are substantially planar and parallel to one another. First and second reinforcing mesh sheets are disposed substantially parallel to one another, next to the first and second major faces, respectively, and embedded in the main body. Recesses are arrayed in the first major face. Each recess extends through a respective opening in the first mesh sheet.

Abstract: Methods and systems may include high speed camera to capture a video of a display output, a robotic arm to interact with a device, a processor, and a computer readable storage medium having a set of instructions. If executed by the processor, the instructions cause the system to identify one or more user experience characteristics based on the captured video, and generate a report based on the one or more user experience characteristics. The report may include a perceptional model score that is generated based on the user experience characteristics as well as other parameters. The user experience characteristics could include response time, frame rate and run time characteristics.

Abstract: Diagnostic codes from a vehicle or other system in transit are transmitted to an opportunity server. The opportunity server searches for potential providers according to user preferences, specifications of the system in transit, and location of the provider in relationship to the travel itinerary of the mobile system. Requests for bids are issued to potential providers, and offers are received and coalesced from the providers. The operator of the vehicle is presented with one or more coalesced offers. Upon selection of an offer by the operator, the service is scheduled, including arranging for parts, personnel and facilities.

Abstract: Plasma etching is controlled utilizing two etchant gases to form a plasma so as to obtain controlled (e.g., uniform) etch rate across a wafer. One etchant gas forms appositive plasma, which is the dominant plasma. The other etchant gas forms a negative plasma, which is the secondary plasma. The ratio of dominant plasma to the secondary plasma can be adjusted such that ion densities are uniform across the wafer, resulting in uniform etch rate over the wafer.

Abstract: Plasma etching is controlled utilizing two etchant gases to form a plasma so as to obtain controlled (e.g., uniform) etch rate across a wafer. One etchant gas forms a positive plasma, which is the dominant plasma. The other etchant gas forms a negative plasma, which is the secondary plasma. The ratio of dominant plasma to the secondary plasma can be adjusted such that ion densities are uniform across the wafer, resulting in uniform etch rate over the wafer.

Abstract: Plasma etching is controlled utilizing two etchant gases to form a plasma so as to obtain controlled (e.g., uniform) etch rate across a wafer. One etchant gas forms a positive plasma, which is the dominant plasma. The other etchant gas forms a negative plasma, which is the secondary plasma. The ratio of dominant plasma to the secondary plasma can be adjusted such that ion densities are uniform across the wafer, resulting in uniform etch rate over the wafer.

Abstract: The invention provides an improved process for the preparation of 17-esters of 9.alpha.,21 -dihalo-pregnane-11.beta.,17.alpha.-diol-20-ones, and in particular for the preparation of 17-esters of anti-inflammatory steroids according to the following scheme: ##STR1## wherein RCO, R.sup.1, X, Y and the dotted line are as defined in the specification. The novel process is especially suitable for the preparation of Mometasone Furoate.