Patents by Inventor Albert L. Lu

Albert L. Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11155883
    Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
    Type: Grant
    Filed: January 14, 2019
    Date of Patent: October 26, 2021
    Inventors: Scott Diehn, Albert L Lu, Timothy M Nowatzki, Douglas S Nubel, M Alejandra Pascual, James C Register, III, Christopher J Scelonge, Joshua K Young, Cathy Xiaoyan Zhong, Erin L Crowgey
  • Publication number: 20210321626
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabrotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-236 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is D. virgifera virgifera, D. barberi, D. speciosa, or D.
    Type: Application
    Filed: April 17, 2021
    Publication date: October 21, 2021
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: KAREN E BROGLIE, KEVIN ANDREW KRISS, ALBERT L LU, MANI MUTHALAGI, JAMES KEVIN PRESNAIL
  • Patent number: 11028407
    Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Grant
    Filed: April 19, 2017
    Date of Patent: June 8, 2021
    Inventors: Albert L Lu, Gusui Wu
  • Publication number: 20210092961
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: June 14, 2018
    Publication date: April 1, 2021
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: JENNIFER KARA BARRY, ANGEL ELIZABETH GRACE D'OLIVIERA, RYAN MICHAEL GERBER, KEVIN HAYES, ALBERT L LU, AMY LUM, UTE SCHELLENBERGER, ERIC SCHEPERS, JEFFREY SOPA, WEIPING XIE, NASSER YALPANI
  • Patent number: 10876132
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with one or more nucleic acid sequence encoding insecticidal protein(s) and one or more silencing element(s). In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The molecular and breeding stacks find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Grant
    Filed: March 3, 2016
    Date of Patent: December 29, 2020
    Assignees: E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Scott Henry Diehn, Xu Hu, Albert L. Lu, Lu Liu, James Kevin Presnail, Gary A. Sandahl, Ute Schellenberger, Gusui Wu
  • Publication number: 20200332314
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: November 29, 2018
    Publication date: October 22, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: ALBERT L LU, KNUT MEYER, GILDA RAUSCHER, GUSUI WU
  • Publication number: 20200308598
    Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: April 18, 2018
    Publication date: October 1, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: ALBERT L LU, MARK EDWARD NELSON, GUSUI WU, TAKASHI YAMAMOTO
  • Publication number: 20200231985
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a plant insect pest, such as Coleopteran, Hemiptera, or Lepidopteran plant pest, including a Diabrotica, Leptinotarsa, Phyllotreta, Acyrthosiphan, Bemisia, Halyomorpha, Nezara, or Spodoptera plant pest, decrease the expression of a target sequence in the pest. Disclosed are various target polynucleotides set forth in any one of SEQ ID NOS: 1-53 or 107-254 disclosed herein, or variants and fragments thereof, or complements thereof, wherein a decrease in expression of one or more of the sequences in the target pest controls the pest and pest population by insect sterilization (i.e., male and female sterility, reduction of sperm count, egg production and viability) and mating-based sterile insect technique (SIT). Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
    Type: Application
    Filed: April 3, 2020
    Publication date: July 23, 2020
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: XU HU, BLISS MARIE KERNODLE, MOLLIE MARY MCMAHON, ADANE KASSA, XIPING NIU, JAMES KEVIN PRESNAIL, ALBERT L LU, NINA RICHTMAN, JONATHAN WILLIAM ROBESON
  • Publication number: 20200224216
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: January 11, 2018
    Publication date: July 16, 2020
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: NURIA JIMENEZ-JUAREZ, ALBERT L LU, LU LIU, MARK EDWARD NELSON, GUSUI WU
  • Patent number: 10711277
    Abstract: The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for regulatory elements from Eupatorium Vein Clearing Virus. A method for expressing a heterologous nucleotide sequence in a plant using the regulatory element sequences disclosed herein is provided. The method comprises transforming a plant or plant cell with a nucleotide sequence operably linked to one of the regulatory elements of the present disclosure.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: July 14, 2020
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Scott Diehn, Albert L. Lu, Michelle Van Allen
  • Publication number: 20200196609
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Coleopteran plant pest or a Diabarotica plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-236 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is D. virgifera virgifera, D. barberi, D. speciosa, or D. undecimpunctata howardi.
    Type: Application
    Filed: March 2, 2020
    Publication date: June 25, 2020
    Applicant: E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: KAREN E BROGLIE, KEVIN ANDREW KRISS, ALBERT L LU, MANI MUTHALAGI, JAMES KEVIN PRESNAIL
  • Publication number: 20200181630
    Abstract: The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for regulatory elements from Lamium Leaf Distortion Associated Virus. A method for expressing a heterologous nucleotide sequence in a plant using the regulatory element sequences disclosed herein is provided. The method comprises transforming a plant or plant cell with a nucleotide sequence operably linked to one of the regulatory elements of the present disclosure.
    Type: Application
    Filed: February 21, 2020
    Publication date: June 11, 2020
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: SCOTT DIEHN, MICHELLE VAN ALLEN, ALBERT L LU
  • Patent number: 10647995
    Abstract: The present invention relates generally to methods of molecular biology and gene silencing to control pests.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: May 12, 2020
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Xu Hu, Bliss Marie Kernodle, Molly Mary McMahon, Adane Kassa, Xiping Niu, James Kevin Presnail, Albert L. Lu, Nina Richtman, Jonathan William Robeson
  • Publication number: 20200140882
    Abstract: The disclosure provides nucleic acids, and variants and fragments thereof, derived from strains of Bacillus thuringiensis encoding variant polypeptides having increased pesticidal activity against insect pests, including Lepidoptera and Coleopteran. Particular embodiments of the disclosure provide isolated nucleic acids encoding pesticidal proteins, pesticidal compositions, DNA constructs, and transformed microorganisms and plants comprising a nucleic acid of the embodiments. These compositions find use in methods for controlling pests, especially plant pests.
    Type: Application
    Filed: April 19, 2017
    Publication date: May 7, 2020
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: ALBERT L LU, GUSUI WU
  • Publication number: 20190390219
    Abstract: Compositions and methods for controlling pests are provided. The methods involve transforming organisms with a nucleic acid sequence encoding a silencing element and an insecticidal protein. In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The pesticidal proteins find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, Hemipteran, fungi and nematode pest populations and for producing compositions with insecticidal activity.
    Type: Application
    Filed: January 22, 2018
    Publication date: December 26, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: CHAD THOMAS BARRETT, XU HU, ALBERT L LU, LAURA J RUTTMAN, GUSUI WU
  • Publication number: 20190292543
    Abstract: The present invention relates generally to methods of molecular biology and gene silencing to control pests.
    Type: Application
    Filed: December 13, 2017
    Publication date: September 26, 2019
    Applicant: PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: VIRGINIA CRANE, JOHN LINDSEY FLEXNER, XU HU, ADANE KASSA, ALBERT L. LU, XIPING NIU, ZAIQI PAN, AMIT SETHI, GUSUI WU
  • Publication number: 20190271004
    Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity).
    Type: Application
    Filed: May 14, 2019
    Publication date: September 5, 2019
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E. I. DU PONT DE NEMOURS AND COMPANY
    Inventors: RAFAEL HERRMANN, MICHAEL LASSNER, ALBERT L. LU, MARK EDWARD NELSON, JAMES KEVIN PRESNAIL, JANET RICE
  • Publication number: 20190136331
    Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
    Type: Application
    Filed: January 14, 2019
    Publication date: May 9, 2019
    Applicants: PIONEER HI-BRED INTERNATIONAL, INC., E.I. DU PONT DE NEMOURS AND COMPANY
    Inventors: Scott Diehn, Albert L Lu, Timothy M Nowatzki, Douglas S Nubel, M Alejandra Pascual, James C Register, III, Christopher J Scelonge, Joshua K Young, Cathy Xiaoyan Zhong, Erin L Crowgey
  • Publication number: 20190071689
    Abstract: The disclosure provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-033121-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
    Type: Application
    Filed: September 12, 2018
    Publication date: March 7, 2019
    Applicants: E. I. DU PONT DE NEMOURS AND COMPANY, PIONEER HI-BRED INTERNATIONAL, INC.
    Inventors: MARY BEATTY, KENT BRINK, VIRGINIA CRANE, SCOTT DIEHN, ALBERT L. LU, GREGORY J. YOUNG
  • Patent number: 10190179
    Abstract: The invention provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-004114-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: January 29, 2019
    Assignees: PIONEER HI-BRED INTERNATIONAL, INC., E I DU PONT DE NEMOURS AND COMPANY
    Inventors: Scott Diehn, Albert L. Lu, Timothy M. Nowatzki, Douglas S. Nubel, M. Alejandra Pascual, James C. Register, III, Christopher J. Scelonge, Joshua K. Young, Cathy Xiaoyan Zhong, Erin L. Crowgey