Patents by Inventor Albert L. Lu
Albert L. Lu has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20090192117Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lygus genus, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides from specific polypeptide families as disclosed herein, and further provides target polynucleotides set forth in SEQ ID NOS:1-21 or active variants thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Lygus Hesperus.Type: ApplicationFiled: January 9, 2009Publication date: July 30, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. Du Pont de Nemours and CompanyInventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark E. Nelson, James K. Presnail, Janet A. Rice
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Publication number: 20090192116Abstract: Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Aphididae family, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides for specific protein classes and also target polynucleotides as set forth in SEQ ID NOS:1, 2, 3, 4, 5, 6, 7, 8, 9, 10 or active variants or fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Aphis glycines.Type: ApplicationFiled: January 9, 2009Publication date: July 30, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Rafael Herrmann, Michael Lassner, Albert L. Lu, Mark Nelson, James K. Presnail, Janet A. Rice
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Patent number: 7556936Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.Type: GrantFiled: December 5, 2007Date of Patent: July 7, 2009Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Andre R. Abad, Ronald D. Flannagan, Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, Janet A. Rice, James F. Wong, Cao-Guo Yu
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Publication number: 20090077689Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: ApplicationFiled: June 3, 2008Publication date: March 19, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F.H. Wong
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Publication number: 20090077690Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: ApplicationFiled: June 3, 2008Publication date: March 19, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F.H. Wong
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Publication number: 20090077688Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: ApplicationFiled: June 3, 2008Publication date: March 19, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F.H. Wong
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Publication number: 20090031448Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: ApplicationFiled: June 3, 2008Publication date: January 29, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F.H. Wong
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Publication number: 20090031449Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: ApplicationFiled: June 3, 2008Publication date: January 29, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F. H. Wong
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Publication number: 20090025103Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: ApplicationFiled: June 3, 2008Publication date: January 22, 2009Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy Fred McCutchen, Albert L. Lu, Rafael Herrmann, James F.H. Wong
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Publication number: 20090011999Abstract: The present invention provides compositions and methods for orally active Androctonus amoreuxi pesticidal polypeptides. Compositions include novel Androctonus amoreuxi pesticidal polypeptides and biologically active variants thereof. Further provided are methods for modulating the pesticide resistance of plants by expressing the sequences disclosed herein. One method comprises stably transforming into the genome of a plant cell a nucleotide sequence of the present invention operably linked to a heterologous promoter and regenerating a stably transformed plant that expresses the nucleotide sequence. An additional method comprises incorporating a nucleotide sequence of the present invention operably linked to a heterologous promoter into a microorganism and applying said microorganism to the environment of a plant.Type: ApplicationFiled: July 11, 2008Publication date: January 8, 2009Applicant: E.I.du Pont de Nemours and CompanyInventors: Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, James F.H. Wong
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Patent number: 7473821Abstract: Compositions and methods for protecting a plant from an insect pest are provided. Nucleic acid molecules encoding insect protoxins or insect toxins modified to comprise at least one proteolytic activation site that is sensitive to an insect gut protease are provided. Cleavage of a modified insect protoxin at the proteolytic activation site by an insect gut protease produces an active insect toxin in the gut of the insect pest. Cleavage of a modified insect toxin of the invention at a proteolytic activation site results in the production of an active insect toxin in the insect gut that displays improved pesticidal activity relative to the insect toxin that lacks the proteolytic activation site. Methods of using the modified insect protoxin and modified insect toxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided.Type: GrantFiled: June 7, 2006Date of Patent: January 6, 2009Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Andre R. Abad, Gary C. Chun, Ronald D. Flannagan, Rafael Herrmann, Albert L. Lu, Janet A. Rice, Eric J. Schepers
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Patent number: 7456334Abstract: The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for a root-preferred promoter for the gene encoding Cr1Bio. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method includes stably incorporating into the genome of a plant cell a nucleotide sequence operably linked to the root-preferred promoter of the present invention and regenerating a stably transformed plant that expresses the nucleotide sequence.Type: GrantFiled: August 2, 2007Date of Patent: November 25, 2008Assignees: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Scott Diehn, Albert L. Lu, Lynne E. Sims, Kim R. Ward
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Patent number: 7442855Abstract: The present invention relates to isolated nucleic acids encoding plant cyclotides. The invention also relates to the construction of a chimeric gene encoding all or a portion of the plant cyclotides, in sense or antisense orientation, wherein expression of the chimeric gene results in the production of altered levels of plant cyclotides in a transformed host cell.Type: GrantFiled: February 22, 2007Date of Patent: October 28, 2008Assignee: E. I. du Pont De Nemours and CompanyInventors: Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, Janet A. Rice, Clement W. K. Waine
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Patent number: 7439348Abstract: The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for an inducible promoter for the gene encoding a maize deoxyhypusine synthase. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method comprises stably incorporating into the genome of a plant cell a nucleotide sequence operably linked to the root-preferred promoter of the present invention and regenerating a stably transformed plant that expresses the nucleotide sequence.Type: GrantFiled: January 10, 2006Date of Patent: October 21, 2008Assignees: Pioneer Hi-Bred International, Inc., E.I. du pont de Nemours and CompanyInventors: Scott Diehn, Albert L. Lu, Billy F. McCutchen, Lynne E. Sims, Kim R. Ward
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Publication number: 20080234130Abstract: Methods and compositions are provided related to improved plants that are tolerant to more than one herbicide. Particularly, the invention provides plants that are tolerant of glyphosate and are tolerant to at least one ALS inhibitor, and methods of use thereof. The glyphosate/ALS inhibitor-tolerant plants comprise a polynucleotide that encodes a polypeptide that confers tolerance to glyphosate and a polynucleotide that encodes an ALS inhibitor-tolerant polypeptide. In specific embodiments, a plant of the invention expresses a GAT polypeptide and an HRA polypeptide. Methods to control weeds, improve plant yield, and increase transformation efficiencies are provided.Type: ApplicationFiled: August 22, 2006Publication date: September 25, 2008Applicants: Pioneer Hi-Bred International, Inc., E.I. du Pont de Nemours and CompanyInventors: Billy Fred McCutchen, Linda A. Castle, Timothy K. Chicoine, Hyeon-Je Cho, Jon S. Claus, Jerry M. Green, Anthony D. Guida, Christine B. Hazel, Matthew J. Heckert, Jeffrey M. Hegstad, James M. Hutchison, Donglong Liu, Albert L. Lu, Wayne J. Mehre, York Moy, Paul D. Olson, Kenneth A. Peeples, David W. Saunders, Mark D. Vogt, Jack Q. Wilkinson, James F. H. Wong
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Publication number: 20080200415Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.Type: ApplicationFiled: November 14, 2007Publication date: August 21, 2008Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANYInventors: Andre Abad, Ronald D. Flannagan, Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, Janet A. Rice, James F. Wong, Cao-Guo Yu
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Patent number: 7414173Abstract: The present invention provides compositions and methods for isolated nucleic acid molecules encoding orally active Androctonus amoreuxi pesticidal polypeptides. Compositions include novel nucleotide sequences encoding Androctonus amoreuxi pesticidal polypeptides, and biologically active variants thereof. Further provided are methods for modulating the pesticide resistance of plants using the nucleotide sequences disclosed herein. One method comprises stably transforming into the genome of a plant cell a nucleotide sequence of the present invention operably linked to a heterologous promoter and regenerating a stably transformed plant that expresses the nucleotide sequence. An additional method comprises incorporating a nucleotide sequence of the present invention operably linked to a heterologous promoter into a microorganism and applying said microorganism to the environment of a plant.Type: GrantFiled: July 11, 2003Date of Patent: August 19, 2008Assignee: E.I. du Pont de Nemours and CompanyInventors: Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, James F. H. Wong
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Patent number: 7396980Abstract: Methods and compositions for modulating development and defense responses are provided. Nucleotide sequences encoding defensin proteins are provided. The sequences can be used in expression cassettes for modulating development, developmental pathways, and defense responses. Transformed plants, plant cells, tissues, and seed are also provided.Type: GrantFiled: May 6, 2005Date of Patent: July 8, 2008Assignees: Pioneer Hi-Bred International, Inc., E. I. Du Pont de Nemours and CompanyInventors: Carl R. Simmons, Pedro A. Navarro Acevedo, Leslie Harvell, Rebecca Cahoon, Billy F. McCutchen, Albert L. Lu, Rafael Herrmann, James F. Wong
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Patent number: 7393947Abstract: The present invention provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for an inducible promoter for the gene encoding ZmPOX24. A method for expressing a heterologous nucleotide sequence in a plant using the promoter sequences disclosed herein is provided. The method comprises stabling incorporating into the genome of a plant cell a nucleotide sequence operably linked to the root-preferred promoter of the present invention and regenerating a stably transformed plant that expresses the nucleotide sequence.Type: GrantFiled: November 15, 2005Date of Patent: July 1, 2008Assignees: Pioneer Hi-Bred International, Inc., E.I. duPont de Nemours and CompanyInventors: Scott Diehn, Albert L. Lu, Billy F. McCutchen, Lynne E. Sims, Kim R. Ward
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Publication number: 20080124799Abstract: Compositions and methods for protecting a plant from an insect pest are provided. In particular, nucleic acid sequences encoding insect protoxins modified to comprise at least one proteolytic activation site that is sensitive to a plant protease or an insect gut protease are provided. Cleavage of the modified protoxin at the proteolytic activation site by a protease produces an active insect toxin. Methods of using the modified insect protoxin nucleic acid sequences and the polypeptides they encode to protect a plant from an insect pest are provided. Particular embodiments of the invention further provide modified insect protoxin compositions and formulations, expression cassettes, and transformed plants, plant cells, and seeds.Type: ApplicationFiled: December 4, 2007Publication date: May 29, 2008Applicants: Pioneer Hi-Bred International, Inc., E.I. du PONT de NEMOURS and COMPANYInventors: Andre Abad, Ronald D. Flannagan, Rafael Herrmann, Albert L. Lu, Billy F. McCutchen, James K. Presnail, Janet A. Rice, James F. Wong, Cao-Guo Yu