Patents by Inventor Albert L. Vulcano

Albert L. Vulcano has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of 7-aminocephalosporanic acids
    Patent number: 3932392
    Abstract: 7-Aminocephalosporanic acid (7-ACA) and 7-amino-3-methyl-3-cephem-4-carboxylic acid (7-ADCA) are valuable intermediates in the preparation of semi-synthetic cephalosporins. These compounds are commonly prepared by cleaving the amide bond of compounds having the formula ##SPC1##In which R.sup.6 is H or ##EQU1## R is the side chain of a known penicillin, especially phenoxymethyl or benzyl, and the amino and carboxyl functions are blocked; byA. halogenating the blocked compounds Ia or IIa to produce an imino-halide;B. forming an imino-ether from the imino-halide by treatment with an alcohol; andC. mixing said imino-ether with water or an alcohol to produce 7-aminocephalosporanic acid or 7-amino-3-methyl-3-cephem-4-carboxylic acid.The invention claimed is the use of dicyclohexylamine or diisopropylamine instead of a tertiary amine acid scavenger in step A.
    Type: Grant
    Filed: January 14, 1974
    Date of Patent: January 13, 1976
    Assignee: Bristol-Myers Company
    Inventors: David A. Johnson, Steven P. Brundidge, Albert L. Vulcano, Chester Sapino, Jr., James Mahan, Joseph H. Grossman