Abstract: Provided are compounds of Formula (I): wherein R1, R2, X, Ring A, Ring B, and Ring C are as defined herein. Compounds of Formula (I) are useful as inhibitors of DNA-PK. Also provided are pharmaceutical compositions comprising said compounds and methods of using the compounds and compositions in the treatment of various diseases, conditions, and disorders.

Abstract: An imitation learning system may learn how to play a video game based on user interactions by a tester or other user of the video game. The imitation learning system may develop an imitation learning model based, at least in part, on the tester's interaction with the video game and the corresponding state of the video game to determine or predict actions that may be performed when interacting with the video game. The imitation learning system may use the imitation learning model to control automated agents that can play additional instances of the video game. Further, as the user continues to interact with the video game during testing, the imitation learning model may continue to be updated. Thus, the interactions by the automated agents with the video game may, over time, almost mimic the interaction by the user enabling multiple tests of the video game to be performed simultaneously.

Abstract: A method to obtain a cache miss ratio curve where a memory blocks of a cache have variable block sizes. By stacking sets of counters, each set being for a different block size, a stack distance for variable block sizes can be obtained and used to determine a miss ratio curve. Such curve can then be used to select a cache size that is appropriate for an application without requiring excessive memory. Methods can be used for batches of request, can apply limits to block sizes, and rounding for intermediary block sizes, they can be used with pruning, and their space complexity can be held constant.

Abstract: A surgical simulator comprising a haptic arm capable of simulating forces generated during surgery from interactions between a surgical tool and tissue operated upon. The simulator further comprises a visual display capable of depicting a three-dimensional image of the simulated surgical tool and a physics-based computer model of the tissue. The haptic arm controls the movement and orientation of the simulated tool in the three-dimensional image, and provides haptic feedback forces to simulate forces experienced during surgery. Methods for simulating surgery and training users of the simulator are also described.

Abstract: The present invention relates to an etching composition and a method of producing a MXene. The etching composition of the present invention can stably and quickly produce a MXene at high temperature. The etching composition of the present invention can produce a MXene in high yield. The etching composition of the present invention can easily produce various types of MXenes. A method using the etching composition of the present invention can produce a MXene having excellent electrochemical and mechanical properties.

Abstract: A surgical simulator comprising a haptic arm capable of simulating forces generated during surgery from interactions between a surgical tool and tissue operated upon. The simulator further comprises a visual display capable of depicting a three-dimensional image of the simulated surgical tool and a physics-based computer model of the tissue. The haptic arm controls the movement and orientation of the simulated tool in the three-dimensional image, and provides haptic feedback forces to simulate forces experienced during surgery. Methods for simulating surgery and training users of the simulator are also described.

Abstract: Disclosed in the present specification are a two-dimensional MXene surface-modified with a metal-organic network, a method of preparing the same, a MXene organic ink containing the same, and uses (e.g., an electromagnetic wave shielding material). In one aspect, the two-dimensional MXene surface-modified with a metal-organic network according to the present invention can use various organic ligands by linking the surface with the organic through the metal, and can be stably dispersed in various organic solvents, especially in industrial non-polar organic solvents as well as polar organic solvents, thereby being applied to a more general-purpose technologies, and securing stability against chemical oxidation to improve long-term stability.

Abstract: Disclosed are compositions and methods for inhibiting abnormal protein accumulation, promoting motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions through expression of a nucleic acid sequence encoding cyclin F in motor neurons with an abnormally low level or activity of cyclin F. Also disclosed are methods for identifying agents that promote survival of motor neurons, inhibit degeneration of motor neurons and/or inhibit abnormal protein accumulation in motor neurons, identifying agents that are useful for treating neurodegenerative conditions, diagnosing neurodegenerative conditions, predicting the progression of neurodegenerative conditions, and monitoring the effectiveness of a therapy in reducing the progression of a neurodegenerative condition.

Abstract: A dispensing gun with an onboard tool stowage system is provided and has a frame body that includes a handle housing and a cartridge frame portion extending from said handle housing. The cartridge frame portion is configured for receiving a cartridge of work material therein. The frame body further includes at least one retention structure that has at least one receiving post protruding from said frame body. The dispensing gun further includes at least one accessory tool configured for detachable coupling with said at least one receiving post when stowed thereon, and a drive mechanism that is operably coupled to said frame body. The drive mechanism includes a drive member which passes displaceably into the cartridge frame portion responsive to operation of a trigger operatively disposed in the handle housing.

Abstract: A wiper blade assembly including a center mounting base having two pockets extending along a length of the center mounting base, a gap between the two pockets, an adapter holder mounted to the center mounting base and including a first recess at a first side of the adapter holder and a second recess at a second side of the adapter holder, and two springs positioned within the two pockets of the center mounting base.

Abstract: A pain-relief device for treating pain related to soft tissue injuries and nerve pain has a broken and at least partially interconnected, conductive layer made of metal particles which are screen printed on a flexible substrate. No attempt is made to electrically insulate any of the metal particles from adjacent particles. The device can be configured either as a pain-relief patch, or as a pain-relief temporary tattoo. Both the patch and the temporary tattoo are adhered to a patient's skin at a site of pain with a non-allergenic adhesive. The flexible substrate for the pain-relief patch is a polymeric material such as polyester-based thermoplastic polyurethane. The flexible substrate for the temporary tattoo is gum arabic coated decal paper that can be removed after the temporary tattoo is adhered to the patient's skin.

Abstract: A surgical simulator comprising a haptic arm capable of simulating forces generated during surgery from interactions between a surgical tool and tissue operated upon. The simulator further comprises a visual display capable of depicting a three-dimensional image of the simulated surgical tool and a physics-based computer model of the tissue. The haptic arm controls the movement and orientation of the simulated tool in the three-dimensional image, and provides haptic feedback forces to simulate forces experienced during surgery. Methods for simulating surgery and training users of the simulator are also described.

Abstract: A polymer composition and aerospace component including the polymer composition is disclosed, and the polymer composition includes a phenol-formaldehyde resin having a) a phenol derived from hydrolyzation of a bio-agnostic, plant-based material comprising ortho hydroxy benzyl alcohol; b) a phenol derived from reduction of a bio-agnostic, plant-based material comprising ortho hydroxy benzyl alcohol; and c) condensation products from the phenol derived from hydrolyzation of a bio-agnostic, plant-based material comprising ortho hydroxy benzyl alcohol.

Abstract: A surgical simulator comprising a haptic arm capable of simulating forces generated during surgery from interactions between a surgical tool and tissue operated upon. The simulator further comprises a visual display capable of depicting a three-dimensional image of the simulated surgical tool and a physics-based computer model of the tissue. The haptic arm controls the movement and orientation of the simulated tool in the three-dimensional image, and provides haptic feedback forces to simulate forces experienced during surgery. Methods for simulating surgery and training users of the simulator are also described.

Abstract: The invention relates to compounds of Formula (I) and pharmaceutically acceptable salts thereof as defined in the description; to their use in medicine; to compositions containing them; to processes for their preparation; and to intermediates used in such processes. The compounds of Formula (I) may inhibit the activity of papain-like protease (PLpro) and may be useful in the treatment of viral infections, in particular viral infections associated with PLpro activity and/or expression such as coronaviruses infections.

Abstract: In an aspect, the present disclosure provides a heat-treated transition metal carbonitride MXene film annealed at high temperatures and a polymer composite comprising the same. In another aspect, the present disclosure provides a method for producing a heat-treated transition metal carbonitride MXene film comprising: obtaining a MXene aqueous solution containing dispersed 2-dimensional (2D) MXenes through an acid etching process; filtering the obtained MXene aqueous solution through a vacuum filtration process to produce a free-standing film; and annealing the produced free-standing film at high temperatures to obtain a heat-treated transition metal carbonitride MXene film. In still another aspect, the present disclosure provides an electromagnetic interference (EMI) shielding method comprising: superposing a coating comprising a heat-treated transition metal carbonitride MXene film on at least one surface of an object in a contact or non-contact manner.

Abstract: Provided herein are modified cyclin F polypeptides and nucleic acid molecules encoding the same. In particular, provided herein are modified cyclin F polypeptides that have increased cytoplasmic targeting compared to wild-type cyclin F polypeptides, and functional, truncated modified cyclin F polypeptides, and nucleic acid molecules encoding the same. Also provided herein is the use of the modified cyclin F polypeptides and encoding nucleic acid molecules for enhancing motor neuron survival, inhibiting motor neuron degeneration and treating neurodegenerative conditions, in particular those associated with neuronal TDP-43 proteinopathy.

Abstract: The present specification discloses an electrochemical catalyst of core-shell structure and manufacturing method thereof. The electrochemical catalyst according to one embodiment of the disclosure provides an effect of being stable in an alkaline environment that is not lost in an aqueous solution while having a high ion exchange capacity and a method for preparing the same.

Abstract: The specification relates an ionomer comprising a compound derived from N,N-diallylamine and a method for preparing the same. The ionomer according to one embodiment of the disclosure has an effect of providing excellent battery performance by controlling the ion exchange capability in a wide range while having excellent alkaline durability.