Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disks 17a and spacers (33, 40) are stacked to form a disk stack 17 having a feed well 31 in the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well 31. The fluid then flows into spacer channels (37, 41) within or on the surface of the spacers. The channels (37, 41) communicate the fluid toward the outer edges of the disks 17a. The disk surface past the spacers (33, 40) can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of patterned disks are stacked to form a disk stack having a feed well in the center core of the stack. Each patterned disk has channels defined by spacers, with the channels and spacers being of varying depths, heights, and/or widths. The fluid to be atomized or encapsulated is delivered to the feed well. The fluid then flows into the channels, which communicate the fluid toward the outer edges of the disks. The fluid exits the disk stack from a circumferential gap, which is created by interposing spacing disks between the patterned disks.

Abstract: An adapter for delivering an atomized spray from a syringe. The adapter includes an adapter guide including a side wall, an interior surface of the side wall defining a through-bore and a shoulder in the through-bore. A pin guide is located in the through-bore. The pin guide includes a seat and a sleeve extending from the seat. A spring positioned around the pin guide sleeve and between the pin guide seat and the shoulder, wherein the spring and the sleeve provide a passageway there between. A pin extends from the pin guide seat and through the passageway. Affixing the adapter onto a syringe provides an atomizing delivery device. A method of dispensing an atomized spray from a syringe is provided by affixing the adapter to the syringe.

Abstract: An adapter for delivering an atomized spray from a syringe. The adapter includes an adapter guide including a side wall, an interior surface of the side wall defining a through-bore and a shoulder in the through-bore. A pin guide is located in the through-bore. The pin guide includes a seat and a sleeve extending from the seat. A spring positioned around the pin guide sleeve and between the pin guide seat and the shoulder, wherein the spring and the sleeve provide a passageway there between. A pin extends from the pin guide seat and through the passageway. Affixing the adapter onto a syringe provides an atomizing delivery device. A method of dispensing an atomized spray from a syringe is provided by affixing the adapter to the syringe.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disks 17a and spacers (33, 40) are stacked to form a disk stack 17 having a feed well 31 in the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well 31. The fluid then flows into spacer channels (37, 41) within or on the surface of the spacers. The channels (37, 41) communicate the fluid toward the outer edges of the disks 17a. The disk surface past the spacers (33, 40) can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of patterned disks are stacked to form a disk stack having a feed well in the center core of the stack. Each patterned disk has channels defined by spacers, with the channels and spacers being of varying depths, heights, and/or widths. The fluid to be atomized or encapsulated is delivered to the feed well. The fluid then flows into the channels, which communicate the fluid toward the outer edges of the disks. The fluid exits the disk stack from a circumferential gap, which is created by interposing spacing disks between the patterned disks.

Abstract: Provided is a microsuspension comprising cyclocreatine, or an analog or pharmaceutically acceptable salt thereof

Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

Abstract: A multi-disk spinning disk assembly for atomization and encapsulation applications. A number of disks 17a and spacers (33, 40) are stacked to form a disk stack 17 having a feed well 31 in the center core of the stack. The fluid to be atomized or encapsulated is delivered to the feed well 31. The fluid then flows into spacer channels (37, 41) within or on the surface of the spacers. The channels (37, 41) communicate the fluid toward the outer edges of the disks 17a. The disk surface past the spacers (33, 40) can have various configurations, such as teeth, weirs, or a bigger or smaller diameter, as desired for particular atomization or encapsulation characteristics.

Abstract: The present invention is directed at isoamyl nitrite formulations suitable for use in medicinal applications. The formulations include a composition of isoamyl nitrite in combination with an epoxidized vegetable oil, identified as stabilized isoamyl nitrite. The isoamyl nitrite may also be combined with petrolatum. Methods of treatment of the formulations are applicable to cyanide poisoning, H2S poisoning as well as treatment for elevated blood pressure.

Abstract: The present invention is directed at isoamyl nitrite formulations suitable for use in medicinal applications. The formulations include a composition of isoamyl nitrite in combination with an epoxidized vegetable oil, identified as stabilized isoamyl nitrite. The isoamyl nitrite may also be combined with petrolatum. Methods of treatment of the formulations are applicable to cyanide poisoning, H2S poisoning as well as treatment for elevated blood pressure.

Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.

Abstract: This invention is directed to an apparatus and method for producing microparticles comprising pharmacologically active agents and biodegradable polymers. The apparatus includes a spinning disk containing a reservoir in the center thereof and a flat inclined surface. The apparatus optionally includes serrations and/or a flat surface beneath the periphery of the disk that is parallel to the rotational axis of the disk. The invention is also directed to a method for producing microparticles containing pharmacologically active agents, using the spinning disk apparatus. Formulations containing ophthalmically active agents are provided. Formulations exhibiting zero order release rates are also described.