Abstract: A method and apparatus to assess sudomotor function to detect early stage peripheral distal neuropathy. The method sends a low voltage direct current of 1 to 5 volts between pairs of electrodes for a time of between 15 and 60 seconds, switches the current at the middle of the time and measures the peak and slope of the decreased conductance. The method can be used to assess skin blood flow and/or sweat gland density depending on the direction of the current.

Abstract: A method and system for determining homeostatic risk in a patient, in order to screen metabolic diseases and/or their complications and/or their treatment management, is provided. The method includes receiving, from one or more sensors coupled with the patient, galvanic skin response, bioimpedance, a photoplethysmogram (PTG), and blood pressure from the patient, executing a spectral analysis of the PTG, and calculating a homeostatic risk score based on the galvanic skin response, bioimpedance, blood pressure and PTG, and a display for displaying the homeostatic risk score.

Abstract: A method and system for detecting insulin resistance, diabetes, cardiovascular disease and/or autonomic neuropathy in a patient is provided. The method includes measuring a photoplethysmogram (PTG) and galvanic skin response from the patient, executing a spectral analysis on the PTG, comparing values derived from the PTG and the galvanic skin response of the patient to stored clinical data, calculating a PTG cardiovascular risk score based on the comparison, comparing further derived values to predefined values that correspond to certain diseases, including insulin resistance, diabetes, cardiovascular disease and autonomic neuropathy, and displaying the PTG cardiovascular risk score and said certain diseases that correspond to said predefined values.

Abstract: A method and system for determining homeostatic risk in a patient, in order to screen metabolic diseases and/or their complications and/or their treatment management, is provided. The method includes receiving, from one or more sensors coupled with the patient, galvanic skin response, bioimpedance, a photoplethysmogram (PTG), and blood pressure from the patient, calculating a first score based on the PTG, calculating a second score based on the galvanic skin response, calculating a third score based on the bioimpedance, calculating a fourth score based on the blood pressure, calculating a homeostatic risk score based on the first, second, third and fourth scores that were calculated, wherein the homeostatic risk score corresponds to the homeostatic risk of the patient, and displaying the homeostatic risk score.

Abstract: A method and system for detecting insulin resistance, diabetes, cardiovascular disease and/or autonomic neuropathy in a patient is provided. The method includes measuring a photoplethysmogram (PTG) and galvanic skin response from the patient, executing a spectral analysis on the PTG, comparing values derived from the PTG and the galvanic skin response of the patient to stored clinical data, calculating a PTG cardiovascular risk score based on the comparison, comparing further derived values to predefined values that correspond to certain diseases, including insulin resistance, diabetes, cardiovascular disease and autonomic neuropathy, and displaying the PTG cardiovascular risk score and said certain diseases that correspond to said predefined values.

Abstract: A method and system for determining homeostatic risk in a patient, in order to screen metabolic diseases and/or their complications and/or their treatment management, is provided. The method includes receiving, from one or more sensors coupled with the patient, galvanic skin response, bioimpedance, a photoplethysmogram (PTG), and blood pressure from the patient, calculating a first score based on the PTG, calculating a second score based on the galvanic skin response, calculating a third score based on the bioimpedance, calculating a fourth score based on the blood pressure, calculating a homeostatic risk score based on the first, second, third and fourth scores that were calculated, wherein the homeostatic risk score corresponds to the homeostatic risk of the patient, and displaying the homeostatic risk score.

Abstract: A method and apparatus to assess sudomotor function to detect early stage peripheral distal neuropathy. The method sends a low voltage direct current of 1 to 5 volts between pairs of electrodes for a time of between 15 and 60 seconds, switches the current at the middle of the time and measures the peak and slope of the decreased conductance. The method can be used to assess skin blood flow and/or sweat gland density depending on the direction of the current.

Abstract: The invention relates to a medical device system comprising at least two technologies wherein at least one technology is based on galvanic skin response measurement and at least one technology is based on oximeter wave form measurement wherein software cross analyzes the results to assess a level of homeostasis and presents a homeostasis score. Preferably a pulse oximeter provides a vascular waveform using photoelectrical plethysmography in spectral analysis. Galvanic skin response is assessed using a change in voltage polarity during measurement. Preferably the system includes a) galvanic skin response, b) bioimpedance in tetrapolar mode c) oximeter sensor and d) blood pressure using oscillometric measurements.

Abstract: The invention relates to a method to estimate sytemic vascular resistance (SVR) and cardiac output (CO) from a pulse oximeter (photoplethysmography, PTG), comprising the steps of generating arterial blood pulse wave forms having first and second peaks, generating a Fast Fourier Transform and calculating the ratio of the height of the second peak (B) to the first peak (A) across the entire measurement using the equation FFTRI to estimate SVR, and the equation CO=(SR/FFTRI)×80 to estimate CO, where SR=S2/S1 and wherein SI and S2 are the areas under the whole PTG wave and the part in diastolic phase, respectively. ? n = 2 N ? FFT 2 ? ( f n ) / ? n = 1 N ? FFT 2 ? ( f n ) .

Abstract: The invention provides a medical device system comprising at least two technologies wherein at least one technology is based on bio-impedance measuring and/or at least one technology is based on spectrophotometry measurements wherein software cross analyses the results to assess the homeostasis of an individual. The technologies measure a variety of parameters. In one embodiment the bioimpedance measuring equipment measures in bipolar mode and in tetrapolar mode and the spectophotmeter measuring equipment comprises a pulse oximeter. The system and homeostasis score can be used to determine and monitor therapy for a patient.