Abstract: A pharmaceutical composition is prepared wherein a biologically active conjugated protein is selectively conjugated to at least one heparin fragment having a terminal 2,5-anhydro-D-mannose residue which has an aldehyde not involved in intramolecular hemiacetal formation. The resulting conjugate has a prolonged half-life as compared to native protein and is able to deliver heparin to the site of clots or to prevent reocclusion within the blood stream. Typical proteins include enzymes such as plasminogen activators, and in particular tissue plasminogen activators, and erythropoietin, hormones, antibodies and the like.

Abstract: A pharmaceutical composition is prepared wherein a biologically active conjugated plasminogen activator is selectively conjugated to at least one heparin fragment having a terminal 2,5-anhydro-D-mannose residue which has an aldehyde not involved in intramolecular hemiacetal formation. The resulting conjugate has a prolonged half-life as compared to native tissue plasminogen activator and is able to deliver heparin to the site of clot dissolution to prevent reocclusion.

Abstract: Disclosed are catalyst support compositions comprised of alumina and titania at a weight ratio of about 0.3:1 to 1:0.3 respectively, and solid porous particles.

Abstract: Supported catalysts comprised of one or more metals of Group VIII, optionally one or more metals from Group IB and IIA, aluminum and silicate are used for hydrogenating hydrogenatable organic compounds. The catalysts can be produced by coprecipitating metal ions from Group VIII, optionally metal ions from Groups IB and IIA, aluminum ions, and silicate ions, in the presence of solid porous particles.

Abstract: Disclosed are novel catalyst support compositions and novel catalyst based thereon as well as methods for preparing same. The novel support compositions are prepared by coprecipitating aluminum ions and silicate ions in the presence of solid porous particles. One method for preparing the novel catalyst of the invention is to coprecipitate at least one catalytically active metal during the coprecipitation of the solid support composition. In preferred embodiments of the present invention the catalytically active metal is from Group VIII of the Periodic Table of the Elements, preferably nickel, and/or cobalt, and the resulting catalyst can optionally contain one or more metals from either Group IB or IIA of the Periodic Table of the Elements.

Abstract: Supported coprecipitated catalyst comprised of aluminum and metals from Group VIII and Groups IIA of the Periodic Table of the Elements are disclosed. The catalyst are produced by preparing an aqueous mixture containing the ions of said metals, aluminum ions, and solid porous support particles to form a reaction mixture of the metal ions and aluminum ions with the solid porous support particles. The reaction mixture is heated and a precipitating agent added to coprecipitate solid support particles.

Abstract: Supported coprecipitated catalysts comprised of one or more metals of Group VIII, one or more metals of Group IIA, and aluminum are used for hydrogenating hydrogenatable organic compounds. The catalysts are produced by preparing, under agitation; an aqueous mixture containing ions of Group VIII, Group IIA, and aluminum, as well as solid porous particles to form a coprecipitate of the metal ions and aluminum ions with the solid porous support particles; heating the aqueous reaction mixture; and adding precipitating agent to precipitate the metal ions and aluminum ions onto the solid support.

Abstract: Supported coprecipitated non-ferrous Group VIII metal aluminum catalysts are disclosed. The catalysts are produced by preparing an aqueous mixture containing the metal ions, aluminum ions and solid porous support particles under agitation to form a coprecipitate of the metal ions and aluminum ions with the solid porous support particles; heating the aqueous reaction mixture; and adding precipitating agent to further precipitate the metal ions and aluminum ions onto the solid support.

Abstract: Supported coprecipitated non-ferrous Group VIII metal aluminum catalysts are used for hydrogenating hydrogenatable organic compounds. The catalysts are produced by preparing an aqueous mixture containing the metal ions, aluminum ions and solid porous support particles under agitation to form a coprecipitate of the metal ions and aluminum ions with the solid porous support particles; heating the aqueous reaction mixture; and adding precipitating agent to further precipitate the metal ions and aluminum ions onto the solid support.