Patents by Inventor Albert R. Nazareth
Albert R. Nazareth has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20150226752Abstract: An improved qualitative or semi-quantitative diagnostic test for measuring low levels of any analyte, such as hCG, in a biological sample, such as urine. The test comprises a test device containing reagents for the detection of the monitored analyte and an electronic reader that measures color development at a detection area of the device. The color development is converted to an electronic or digital signal. Improvements were made to the electronic reader to optimize the coverage of the detection area on the test strip. This improves the detection sensitivity and consistency of the test result while maintaining its reliability and accuracy.Type: ApplicationFiled: February 12, 2014Publication date: August 13, 2015Applicant: CHURCH & DWIGHT CO., INC.Inventors: Albert R. Nazareth, Benedict Zin, Andy Sturman, Shang Li
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Patent number: 8999728Abstract: The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device is a pregnancy test device, which detects human chorionic gonadotropin (hCG) as an indicator of pregnancy. Devices with improved clinical sensitivity are provided which are capable of detecting all clinically relevant hCG isoforms.Type: GrantFiled: December 21, 2011Date of Patent: April 7, 2015Assignee: Church & Dwight Co., Inc.Inventors: Albert R. Nazareth, Shang Li
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Patent number: 8927262Abstract: The present invention is related to a diagnostic test kit for detecting luteinizing hormone (LH) in a biological sample at a concentration relative to a threshold concentration of LH. The device can include a release medium formed of a first material and including a labeled conjugate with a detectable label and a first binding member reactive with a first epitope of LH and a capture medium formed of a second, different material, in fluid communication with the release medium. The capture medium includes a result site having immobilized thereon a capture component capable of directly or indirectly binding LH that is bound to the labeled conjugate. The device is calibrated such that color development at the result site occurs only when the LH concentration of the liquid sample is greater than the threshold concentration.Type: GrantFiled: October 4, 2010Date of Patent: January 6, 2015Assignee: Church & Dwight Co., Inc.Inventors: Albert R. Nazareth, Timothy Snowden, Mary Beth Boyle
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Publication number: 20140256032Abstract: Test kits for assessing male fertility include a sample holder containing at least one sample chamber, a laser light source, and a light detector to detect scattered light intensity from the sample chamber. The sample holder may include multiple sample chambers connected by sperm swim channels. The test kit may have a housing with a maximum linear dimension of no more than 100 mm. Processing circuitry may be provided that is configured to produce a sperm count and/or sperm motility measurements by processing data from scattered light intensity measurements.Type: ApplicationFiled: February 19, 2014Publication date: September 11, 2014Applicant: CHURCH & DWIGHT CO., INC.Inventors: Nicholas James Wooder, Giles Sanders, Roger Brian Minchin Clarke, Albert R. Nazareth, Shang Li
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Publication number: 20140254004Abstract: Test kits for assessing male fertility include a sample holder defining an object plane, a lens, and a two dimensional light sensor defining an image plane arranged along a common linear axis. The distance between the object plane and the image plane may be no more than 50 mm, and may be no more than 30 mm. A lens aperture may have an area of 1-10 mm2. The test kit may have a housing with a maximum linear dimension of no more than 100 mm. Processing circuitry may be provided that is configured to produce a sperm count and/or sperm motility measurements by processing image data from the two-dimensional light sensor.Type: ApplicationFiled: February 19, 2014Publication date: September 11, 2014Applicant: Church & Dwight Co., Inc.Inventors: Nicholas James Wooder, Giles Sanders, Albert R. Nazareth, Shang Li
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Publication number: 20140248717Abstract: An electronically processed single-step test device for detecting the presence of a preselected analyte in a fluid. The device includes a hollow rectangular outer casing, disposed within co-joined upper and lower sections of the casing are assay material, an electronic processing system, and a display. The display is observable through a viewing window. The assay material is a sorptive material including a fluid sample application region in the form of a sample wick in fluid communication with a test strip. The test strip includes an analyte capture region adjacent to a light shield. The system includes lights which are alternately pulsed or energized over predetermined periods of time to determine if fluid test results show a marker or markers in the capture region indicative of the presence of a preselected analyte in the fluid. If so, Yes+ is displayed on the display otherwise, No? is displayed on the display.Type: ApplicationFiled: May 12, 2014Publication date: September 4, 2014Applicant: CHURCH & DWIGHT CO., INC.Inventors: Albert R. Nazareth, Francis T. Delahanty, Gregory M. Bandru, Henry J. Wieck, Stephen R. Synakowski
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Patent number: 8802427Abstract: The present invention is related to a diagnostic test kit that assesses ovarian reserve by measuring Follicle Stimulating Hormone (FSH) in a liquid sample. The sample can be deposited on a first portion of the device for transport to a second portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a test site, in fluid communication with the release medium and formed of a second, different material.Type: GrantFiled: June 9, 2009Date of Patent: August 12, 2014Assignee: Church & Dwight Co., Inc.Inventors: Albert R. Nazareth, Timothy Snowden, Mary Beth Boyle, Shang Li
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Patent number: 8722395Abstract: The invention is an electronically processed single-step test device for detecting the presence of a preselected analyte in a fluid. The device includes a hollow rectangular outer casing, disposed within co-joined upper and lower sections of the casing are assay material, an electronic processing system, and a LCD display. The LCD display is observable through a viewing window. The assay material is a sorptive material including a fluid sample application region in the form of a sample wick in fluid communication with a test strip. The test strip includes an analyte capture region adjacent to a light shield. The electronic processing system includes red and green LEDs which are alternately pulsed or energized over predetermined periods of time to determine if fluid test results show a marker or markers in the capture region indicative of the presence of a preselected analyte in the fluid. If so, Yes+ is displayed on the LCD. If not, No? is displayed on the LCD.Type: GrantFiled: June 3, 2010Date of Patent: May 13, 2014Assignee: Church & Dwight Co., Inc.Inventors: Albert R. Nazareth, Francis T. Delahanty, Gregory M. Bandru, Henry J. Wieck, Stephen R. Synakowski
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Patent number: 8623635Abstract: The invention is an electronically processed single-step test device for detecting the presence of a preselected analyte in a fluid. The device includes a hollow rectangular outer casing, disposed within co-joined upper and lower sections of the casing are assay material, an electronic processing system, and a LCD display. The LCD display is observable through a viewing window. The assay material is a sorptive material including a fluid sample application region in the form of a sample wick in fluid communication with a test strip. The test strip includes an analyte capture region adjacent to a light shield. The electronic processing system includes red and green LEDs which are alternately pulsed or energized over predetermined periods of time to determine if fluid test results show a marker or markers in the capture region indicative of the presence of a preselected analyte in the fluid. If so, Yes+ is displayed on the LCD. If not, No? is displayed on the LCD.Type: GrantFiled: June 3, 2010Date of Patent: January 7, 2014Assignee: Church & Dwight Co., Inc.Inventors: Albert R. Nazareth, Francis T. Delahanty, Gregory M. Bandru, Henry J. Wieck, Stephen R. Synakowski
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Publication number: 20130217136Abstract: An improved qualitative or semi-quantitative diagnostic test for low levels of any analyte, such as hCG, in a biological sample, such as urine. The test comprises of a test device containing reagents for the detection of the monitored analyte and an electronic reader that measures color development at a detection area of the device. The color development is converted to an electronic or digital signal. Improvements were made to the detection process to optimize the detection of a valid fluid front, increase the detection limit without compromising the reliability and accuracy of the test system, and improve the determination of test result validity.Type: ApplicationFiled: February 22, 2012Publication date: August 22, 2013Applicant: CHURCH & DWIGHT CO., INC.Inventors: Albert R. Nazareth, Andy Sturman, Benedict Zin
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Publication number: 20130164858Abstract: The invention comprises a device for detecting an analyte in a liquid sample deposited on a first portion of the device for transport to a second portion of the device that is in fluid contact with the first portion. In specific embodiments, the device is a pregnancy test device, which detects human chorionic gonadotropin (hCG) as an indicator of pregnancy. Devices with improved clinical sensitivity are provided which are capable of detecting all clinically relevant hCG isoforms.Type: ApplicationFiled: December 21, 2011Publication date: June 27, 2013Applicant: CHURCH & DWIGHT CO., INC.Inventors: Albert R. Nazareth, Shang Li
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Publication number: 20130157379Abstract: Described herein are methods and devices for detecting the presence of an analyte in a liquid sample. In some embodiments, methods and devices for the detection of an antigen in a body fluid using a plurality of species-specific antibodies are provided. A sandwich complex may be formed using primary antibodies derived from two different species.Type: ApplicationFiled: December 20, 2011Publication date: June 20, 2013Applicant: CHURCH & DWIGHT CO., INC.Inventors: Albert R. Nazareth, Timothy Snowden, Mary-Beth Boyle
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Patent number: 8431405Abstract: The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a proximal portion of the device for transport to a distal portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a capture site, in fluid communication with the release medium and formed of a second, different material. At least one of the release medium and the capture medium includes a binding member that exhibits a moderate to high affinity for hCG-H and is selectively or preferentially reactive with hCG-H.Type: GrantFiled: August 22, 2012Date of Patent: April 30, 2013Assignee: Church & Dwight Co., Inc.Inventors: Albert R. Nazareth, Timothy Snowden
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Publication number: 20120315656Abstract: The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a proximal portion of the device for transport to a distal portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a capture site, in fluid communication with the release medium and formed of a second, different material. At least one of the release medium and the capture medium includes a binding member that exhibits a moderate to high affinity for hCG-H and is selectively or preferentially reactive with hCG-H.Type: ApplicationFiled: August 22, 2012Publication date: December 13, 2012Applicant: CHURCH & DWIGHT CO., INC.Inventors: Albert R. Nazareth, Timothy Snowden
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Patent number: 8278109Abstract: The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a proximal portion of the device for transport to a distal portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a capture site, in fluid communication with the release medium and formed of a second, different material. At least one of the release medium and the capture medium includes a binding member that exhibits a moderate to high affinity for hCG-H and is selectively or preferentially reactive with hCG-H.Type: GrantFiled: February 12, 2010Date of Patent: October 2, 2012Assignee: Church & Dwight Co., Inc.Inventors: Albert R. Nazareth, Timothy Snowden
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Publication number: 20120083047Abstract: The present invention is related to a diagnostic test kit for detecting luteinizing hormone (LH) in a biological sample at a concentration relative to a threshold concentration of LH. The device can include a release medium formed of a first material and including a labeled conjugate with a detectable label and a first binding member reactive with a first epitope of LH and a capture medium formed of a second, different material, in fluid communication with the release medium. The capture medium includes a result site having immobilized thereon a capture component capable of directly or indirectly binding LH that is bound to the labeled conjugate. The device is calibrated such that color development at the result site occurs only when the LH concentration of the liquid sample is greater than the threshold concentration.Type: ApplicationFiled: October 4, 2010Publication date: April 5, 2012Inventors: Albert R. Nazareth, Timothy Snowden, Mary Beth Boyle
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Publication number: 20110201122Abstract: The present invention related to a pregnancy test device that can selectively detect hyperglycosylated human chorionic gonadotropin (hCG-H) in a liquid sample. The sample can be deposited on a proximal portion of the device for transport to a distal portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a capture site, in fluid communication with the release medium and formed of a second, different material. At least one of the release medium and the capture medium includes a binding member that exhibits a moderate to high affinity for hCG-H and is selectively or preferentially reactive with hCG-H.Type: ApplicationFiled: February 12, 2010Publication date: August 18, 2011Inventors: Albert R. Nazareth, Timothy Snowden
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Publication number: 20100311188Abstract: The present invention is related to a diagnostic test kit that assesses ovarian reserve by measuring Follicle Stimulating Hormone (FSH) in a liquid sample. The sample can be deposited on a first portion of the device for transport to a second portion of the device. The device can include a release medium formed of a first material and including a detectable label thereon and a capture medium, including a test site, in fluid communication with the release medium and formed of a second, different material.Type: ApplicationFiled: June 9, 2009Publication date: December 9, 2010Inventors: Albert R. Nazareth, Timothy Snowden, Mary Beth Boyle, Shang Li
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Publication number: 20100240149Abstract: The invention is an electronically processed single-step test device for detecting the presence of a preselected analyte in a fluid. The device includes a hollow rectangular outer casing, disposed within co-joined upper and lower sections of the casing are assay material, an electronic processing system, and a LCD display. The LCD display is observable through a viewing window. The assay material is a sorptive material including a fluid sample application region in the form of a sample wick in fluid communication with a test strip. The test strip includes an analyte capture region adjacent to a light shield. The electronic processing system includes red and green LEDs which are alternately pulsed or energized over predetermined periods of time to determine if fluid test results show a marker or markers in the capture region indicative of the presence of a preselected analyte in the fluid. If so, Yes+ is displayed on the LCD. If not, No? is displayed on the LCD.Type: ApplicationFiled: June 3, 2010Publication date: September 23, 2010Inventors: Albert R. Nazareth, Francis T. Delahanty, Gregory M. Bandru, Henry J. Wieck, Stephen R. Synakowski
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Publication number: 20100239460Abstract: The invention is an electronically processed single-step test device for detecting the presence of a preselected analyte in a fluid. The device includes a hollow rectangular outer casing, disposed within co-joined upper and lower sections of the casing are assay material, an electronic processing system, and a LCD display. The LCD display is observable through a viewing window. The assay material is a sorptive material including a fluid sample application region in the form of a sample wick in fluid communication with a test strip. The test strip includes an analyte capture region adjacent to a light shield. The electronic processing system includes red and green LEDs which are alternately pulsed or energized over predetermined periods of time to determine if fluid test results show a marker or markers in the capture region indicative of the presence of a preselected analyte in the fluid. If so, Yes+ is displayed on the LCD. If not, No? is displayed on the LCD.Type: ApplicationFiled: June 3, 2010Publication date: September 23, 2010Inventors: Albert R. Nazareth, Francis T. Delahanty, Gregory M. Bandru, Henry J. Wieck, Stephen R. Synakowski