Abstract: Provided herein are adeno-associated virus (AAV) compositions that can express a phenylalanine hydroxylase (PAH) polypeptide in a cell, thereby restoring the PAH gene function. Also provided are methods of use of the AAV compositions, and packaging systems for making the AAV compositions.

Abstract: A fishing lure comprises a hook structure including a hook portion for engaging the mouth flesh of a fish, a shank portion connected to the hook portion, and a line securing portion for securing a line to the hook structure. The line securing portion forms an unsecured loop so that a portion of fishing line is movable into the eye of the loop without threading. The lure also comprises a body structure mounted on the hook structure. The body structure has an anchor notch formed thereon and configured to receiving a portion of a looped fishing line.

Abstract: A fishing lure comprises a hook structure including a hook portion for engaging the mouth flesh of a fish, a shank portion connected to the hook portion, and a line securing portion for securing a line to the hook structure. The line securing portion forms an unsecured loop so that a portion of fishing line is movable into the eye of the loop without threading. The lure also comprises a body structure mounted on the hook structure. The body structure has an anchor notch formed thereon and configured to receiving a portion of a looped fishing line.

Abstract: The invention relates to a method for evaluating a pancreas as a source of therapeutically useful islets. A scoring system is set forth whereby 5 criteria are listed. If three criteria are positive, then the pancreas is a suitable source of therapeutically useful islets.

Abstract: The invention relates to the use of macrobeads which have been kept in in vitro storage for long term culture, i.e., for at least about 8 months. The macrobeads surprisingly exhibit continued efficacy in producing therapeutically useful materials. The fact that the macrobeads can be used after long term culture allows the artisan to screen the products so as to make sure that, in addition to being therapeutically useful, they remain safe as implants.

Abstract: The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

Abstract: Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

Abstract: Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

Abstract: The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

Abstract: The invention relates to a method for evaluating a pancreas as a source of therapeutically useful islets. A scoring system is set forth whereby 5 criteria are listed. If three criteria are positive, then the pancreas is a suitable source of therapeutically useful islets.

Abstract: The invention relates to the use of macrobeads which have been kept in in vitro storage for long term culture, i.e., for at least about 8 months. The macrobeads surprisingly exhibit continued efficacy in producing therapeutically useful materials. The fact that the macrobeads can be used after long term culture allows the artisan to screen the products so as to make sure that, in addition to being therapeutically useful, they remain safe as implants.

Abstract: The invention relates to the stem cells, embryonic stem cells in particular. It has been found that, when these stem cells are entrapped such that their proliferation is inhibited, they produce material which inhibits the proliferation of other, non-entrapped cells, including stem cells and neoplastic and/or hyperproliferative, but otherwise normal cells. It has also been found that entrapped cancer cells will produce material which inhibits the proliferation of stem cells. Further, it has been found that the entrapment of the stem cells inhibits their differentiation and thus the entrapment process can serve as a long-term storage device for maintaining the undifferentiated state of at least a portion of the entrapped cells.

Abstract: Compositions of matter are described which contain restricted cancer cells. When so restricted, the cells produce an unexpectedly high amount of material which suppresses cancer cell proliferation. The phenomenon crosses cancer type and species lines. Processes for making these compositions, and their use, are also described.

Abstract: A valve, the housing and gate of which are composed of molded rigid polyvinylchloride, the valve body having an interior chamber with a main upstream inlet and a main downstream outlet and an annular valve seat in the housing, and a gate being arranged in the housing which is spring-biased to a normally closed position with an O-ring in sealing relation on the seat to effectively block fluid flow through the valve and said spring being selected so as to have a resiliency to yield in response to predetermined upstream fluid pressure to unseat the valve member and permit flow of fluid through the valve so long as the predetermined pressure is exceeded.