Abstract: Method of asymmetrically hydrosilylating substrates using catalysts having a ligand of the compound of the formula (I) wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R? is hydrogen, optionally substituted lower alkyl; and R? is hydrogen, halogen, optionally substituted alkyl, hydroxy, amino (e.g., primary, secondary or tertiary), alkenyl; or an enantiomer thereof; or an enantiomeric mixture thereof with a transition metal. Particularly suitable reactions include the asymmetric hydrosilylation of ketones.

Abstract: The present invention provides bipyrimidinyl diphosphine compounds of the formula wherein R is optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; R? and R? are independently optionally substituted alkyl, cycloalkyl, aryl or heteroaryl; or an enantiomer thereof; or an enantiomeric mixture thereof. The compounds of the formula (I) are chiral atropisomeric bipyrimidinyl diphosphine compounds and, thus, may be employed as ligands to generate chiral transition metal catalysts which may be applied in a variety of asymmetric reactions, e.g., in palladium catalyzed asymmetric allylic substitution reactions. The compounds of the present invention are easily accessible in high enantiomeric purity according to the methods disclosed herein.

Abstract: Method for the preparation of asymmetric alkynylated ?-amino esters of the formula wherein R1 and R2 are independently optionally substituted alkyl cycloalkyl, aryl or heteroaryl, and Y is hydrogen or a nitrogen protecting group.

Abstract: A dentifrice composition is disclosed which contains dicalcium phosphate dihydrate and other common ingredients and a zinc sodium tripolyphosphate compound.

Abstract: A dentifrice composition is disclosed which contains an effective amount of a zinc-alkali metal tripolyphosphate compound for the control of dental plaque and dental calculus.

Abstract: A process for the production of sodium phenylpyruvate from calcium phenylpyruvate wherein calcium phenylpyruvate is contacted with a sodium carbonate salt in an inert atmosphere.

Abstract: Formaldehyde is reacted with hydrogen and carbon monoxide with rhodium catalyst in the presence of phosphine ligands having electron-withdrawing substituents, obtaining high selectivity to glycol aldehyde with a stable catalyst system.

Abstract: Formaldehyde is reacted with hydrogen and carbon monoxide in the presence of certain rhodium catalysts and basic organic amine compositions which promote the formation of glycol aldehyde.