Abstract: Lacrimal canalicular delivery systems (LCDS) and their methods of use for the delivery of implants at a specific location into the canaliculus of a subject generally include a lumen, a guide wire, and an implant. The guide wire and implant are within the lumen. When pressure is applied to the guide wire, the guide wire pushes the implant out of the lumen into a specific location into the canaliculus of a subject.

Abstract: An aspiration device to be used with an irrigation-aspiration handpiece may comprise a curved body having a radius of curvature based on a human equatorial lens diameter, an interface adapted to attach the curved body to a first end of an aspiration lumen in the irrigation-aspiration handpiece, and multiple aspiration ports formed in the curved body. The multiple aspiration ports may be adapted to draw material into the aspiration lumen when a suction source is used to apply vacuum pressure at a second of the aspiration lumen while the aspiration lumen is attached to the aspiration device. The multiple aspiration ports may be arranged to distribute the vacuum pressure over an aggregate surface area of the multiple aspiration ports while the suction source applies the vacuum pressure.

Abstract: Lacrimal canalicular delivery systems (LCDS) and their methods of use for the delivery of implants at a specific location into the canaliculus of a subject are described. LCDS generally include a lumen, a guide wire, and an implant. The guide wire and implant are within the lumen. When pressure is applied to the guide wire, the guide wire pushes the implant out of the lumen into a specific location into the canaliculus of a subject.

Abstract: Canalicular occlusion devices are described comprising an occlusive element and a memory frame comprising a memory material. The occlusive element is configured to substantially prevent fluid from flowing through portions of the canaliculus. Also disclosed are methods of occluding a canalicular system with the devices of the present invention.

Abstract: Described herein are methods for treating disorders affecting ocular and non-ocular tissue, such as corneal dystrophies and microsatellite expansion diseases. The methods use a nuclease system, such as Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR associated (Cas) 9 (CRISPR-Cas9), to cut and/or repair genomic DNA. Such methods may further comprise a DNA double-stranded break (DSB) repair system comprising a repair template in combination with a Non-Homologous End-Joining (NHEJ) or Homology Directed Repair (HDR) targeted to the one or more CRISPR-Cas9 cleavage sites.

Abstract: A corneal reshaping kit may include a mold defining a concavity that is sized and shaped for receiving an outer corneal surface, such that a corneal surface pressed against the concavity will adopt a convex shape complementary to the concavity, and a biocompatible, flowable material suitable for introduction into a space within a cornea.