Abstract: The present invention refers to a liposome comprising: a) a phospholipid; b) cholesterol (chol); c) a conjugate comprising a cholesterol moiety, a polyethylene glycol (PEG) moiety and a peptide moiety comprising a RGD sequence, wherein the PEG moiety is covalently attached to the cholesterol moiety by one end via a bond of the type alkyl ether and is covalently attached to the peptide moiety comprising the RGD sequence by the other end: d) a non-lipid cationic surfactant present in a percentage of less than 30% mol in respect to the total mol of the components of the liposome a), b), c) and d); and e) alpha-galactosidase (GLA) enzyme present in a ratio of micrograms of GLA in respect to the total milligrams of the components of the liposome a), b), c) and d) of between and including 2 to 35. It also refers to a pharmaceutical composition that comprises it and to the liposome or the pharmaceutical composition for use as a medicament, in particular for use in the treatment of Fabry disease.

Abstract: A spring actuated pool cue for teaching the strength of cue stroke and aiming of the cue. The spring actuated pool cue includes a cue having a first portion and a second portion. The fist and second portions each have a first end and a second end. The first end of the second portion has a bore extending therein. An intermediate wall extends across the bore. The second end of the first portion is extendable into the first end of second portion. A rod is attached to and extends outwardly away from the second end of the first portion of the cue. The rod extends through an opening in the intermediate wall. An urging means urges the first portion away from the intermediate wall into an extended position. The urging means is positioned between the intermediate wall and the second end of the first portion.