Patents by Inventor Albert Sun-Chi Chan

Albert Sun-Chi Chan has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 9783519
    Abstract: This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds. More particularly, it relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds comprising phenylacetophenone derivatives using oxabenzonorbornadienes with terminal alkynes.
    Type: Grant
    Filed: June 18, 2015
    Date of Patent: October 10, 2017
    Assignees: HONG KONG BAPTIST UNIVERSITY, YUNNAN MINZU UNIVERSITY
    Inventors: Zhaoxiang Bian, Chengyuan Lin, Huaixue Mu, Baomin Fan, Yongyun Zhou, Jingchao Chen, Aiping Lu, Albert Sun-Chi Chan
  • Patent number: 9775857
    Abstract: The present invention relates to chemical constituents of the hydro-alcoholic extract of root of Lasia spinosa (L.) Thwait. More particularly, it relates to the bioactive chemical composition of Lasia spinosa (L.) Thwait and its anticancer effect. The present invention has application in the treatment of human esophageal carcinoma.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: October 3, 2017
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Zhaoxiang Bian, Huaixue Mu, Chengyuan Lin, Hongxi Xu, Dajian Yang, Shilin Chen, Aiping Lu, Albert Sun Chi Chan
  • Patent number: 9655913
    Abstract: The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root of Lasia spinosa Linn. Thwait or chemically synthesized and its specific anticancer/antitumor activity. This invention has a specific application in treating human esophageal cancer.
    Type: Grant
    Filed: June 23, 2016
    Date of Patent: May 23, 2017
    Assignees: Hong Kong Baptist University, Changshu HKBU Technology Company Limited
    Inventors: Zhaoxiang Bian, Huaixue Mu, Chengyuan Lin, Jinjin Wang, Zhijun Yang, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20170035824
    Abstract: Disclosed is a natural compound, Oblongifolin C, isolated from a natural plant comprising Garcinia species such as Garcinia yunnanesis Hu, for its effects of anti-migration and anti-invasion against cancer and its use as an anticancer drug. The treated cancers comprise cervical cancers and esophageal cancers. The cancer treatment comprises inhibition of cancer metastasis and inhibition of autophagic flux.
    Type: Application
    Filed: October 19, 2016
    Publication date: February 9, 2017
    Inventors: Hongxi XU, Yuanzhi LAO, Hongsheng TAN, Naihan XU, Xiaoyu WANG, Kaixian CHEN, Zhaoxiang BIAN, Dajian YANG, Shilin CHEN, Aiping LU, Albert Sun Chi CHAN
  • Publication number: 20170014438
    Abstract: The present invention relates to the bioactive components with the anti-proliferative property. In particular, the invention relates to one flavonol compound isolated from the root of Lasia spinosa Linn. Thwait or chemically synthesized and its specific anticancer/antitumor activity. This invention has a specific application in treating human esophageal cancer.
    Type: Application
    Filed: June 23, 2016
    Publication date: January 19, 2017
    Applicants: Changshu HKBU Technology Company Limited
    Inventors: Zhaoxiang Bian, Huaixue Mu, Chengyuan Lin, Jinjin Wang, Zhijun Yang, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20160374985
    Abstract: The present invention disclosed a compound, proanthocyanidin A1 (PA1), which is isolated from Lasia spinosa (L.) Thwait, for its effects in shortening of clolon length, reducing colonic tissue damage, suppressing colonic myeloperoxidase activity with colitis. The said compound can be used in treating inflammatory diseases and anti-cancer leading compound.
    Type: Application
    Filed: June 23, 2016
    Publication date: December 29, 2016
    Inventors: Zhaoxiang Bian, Huaixue Mu, Chengyuan Lin, Hongxi Xu, Dajian Yang, Shilin Chen, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20160375082
    Abstract: The present invention relates to chemical constituents of the hydro-alcoholic extract of root of Lasia spinosa (L.) Thwait. More particularly, it relates to the bioactive chemical composition of Lasia spinosa (L.) Thwait and its anticancer effect. The present invention has application in the treatment of human esophageal carcinoma.
    Type: Application
    Filed: June 23, 2016
    Publication date: December 29, 2016
    Inventors: Zhaoxiang Bian, Huaixue Mu, Chengyuan Lin, Hongxi Xu, Dajian Yang, Shilin Chen, Aiping Lu, Albert Sun Chi Chan
  • Patent number: 9526706
    Abstract: The present invention relates to a method of using trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.
    Type: Grant
    Filed: June 16, 2015
    Date of Patent: December 27, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Aiping Lu, Albert Sun-Chi Chan
  • Publication number: 20160367498
    Abstract: The present invention relates to a method of using trans-3,5,4?-trihydroxybibenzyl, also known as dihydro-resveratrol for treating acute pancreatitis in a subject in needs thereof. More particularly, the present invention relates to a method of using dihydro-resveratrol, its derivatives and/or chemical variants as a remedial agent. The present invention particularly relates to the amelioration of tissue injury for the management of acute pancreatitis associated pulmonary injury of a subject.
    Type: Application
    Filed: June 16, 2015
    Publication date: December 22, 2016
    Inventors: Zhaoxiang BIAN, Siu Wai TSANG, Hongjie ZHANG, Aiping LU, Albert Sun-Chi CHAN
  • Publication number: 20160368890
    Abstract: This invention relates to the quick and efficient synthesis of anti-tumor or anti-cancer compounds.
    Type: Application
    Filed: June 18, 2015
    Publication date: December 22, 2016
    Inventors: Zhaoxiang BIAN, Chengyuan LIN, Huaixue MU, Baomin FAN, Yongyun ZHOU, Jingchao CHEN, Aiping LU, Albert Sun-Chi CHAN
  • Patent number: 9493419
    Abstract: Quinoline derivatives showing anticancer activities against cancer cell lines of hepatocellular carcinoma (Hep3B), lung carcinoma (A549), esophageal squamous cell carcinoma (HKESC-1, HKESC-4 and KYSE150).
    Type: Grant
    Filed: December 22, 2011
    Date of Patent: November 15, 2016
    Assignee: The Hong Kong Polytechnic University
    Inventors: Johnny Cheuk-on Tang, Albert Sun Chi Chan, Kim Hung Lam, Sau Hing Chan
  • Publication number: 20160303069
    Abstract: The present invention provides compound extracted from Garcinia species and the use of said compound in preventing and treating cancer.
    Type: Application
    Filed: April 15, 2016
    Publication date: October 20, 2016
    Inventors: Hong-xi XU, Yuan-zhi LAO, Zhi-jie DING, Hong ZHANG, Kai-xian CHEN, Hong-sheng TAN, Zhao-xiang BIAN, Cheng-yuan LIN, Shi-lin CHEN, Da-jian YANG, Ai-ping LU, Albert Sun Chi CHAN
  • Patent number: 9468623
    Abstract: The present invention provides compound extracted from Garcinia species and the use of said compound in preventing and treating cancer.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: October 18, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Hong-xi Xu, Yuan-zhi Lao, Zhi-jie Ding, Hong Zhang, Kai-xian Chen, Hong-sheng Tan, Zhao-xiang Bian, Cheng-yuan Lin, Shi-lin Chen, Da-jian Yang, Ai-ping Lu, Albert Sun Chi Chan
  • Patent number: 9408811
    Abstract: Prostate cancer is the most commonly diagnosed cancer in males and one of the leading causes of cancer death. Although treatment options have increased for some patients, overall progress has been modest. Thus, there is a great need to develop new treatments. This invention relates to a method for treating cancer comprising using an anti-cancer compound of formula (I): More particularly, it relates to said anti-prostate cancer compound that can be isolated from Garcinia esculenta or chemically synthesized and its specific anticancer/antitumor activity. The invention has a specific application in treating human prostate cancer.
    Type: Grant
    Filed: July 17, 2014
    Date of Patent: August 9, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Hongxi Xu, Xin Li, Hong Zhang, Yuanzhi Lao, Hongsheng Tan, Xiaoyu Wang, Kaixian Chen, Zhaoxiang Bian, Dajian Yang, Shilin Chen, Aiping Lu, Albert Sun Chi Chan
  • Patent number: 9339488
    Abstract: Cervical cancer is one of the most common malignancies and is associated with a dismal prognosis. The most common therapeutic option for cervical cancer consists of surgery in early stages, and chemotherapy or radiotherapy in more advanced stages of the disease. Although treatment options have increased for some patients, overall progress has been modest. This invention relates to a method for treating cancer comprising administering an anti-cancer compound. More particularly, the present invention relates to an anti-cervical-cancer compound for treating human cervical cancer and tumor.
    Type: Grant
    Filed: July 31, 2014
    Date of Patent: May 17, 2016
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Hongxi Xu, Hong Zhang, Yuanzhi Lao, Xiaoyu Wang, Kaixian Chen, Dajian Yang, Shilin Chen, Chengyuan Lin, Zhaoxiang Bian, Aiping Lu, Albert Sun Chi Chan
  • Patent number: 9321730
    Abstract: The present invention relates methods of preparing quinoline derivative compounds, and administering such compounds in the treatment of solid and non-solid tumors, notably on liver cancer.
    Type: Grant
    Filed: August 21, 2007
    Date of Patent: April 26, 2016
    Assignee: The Hong Kong Polytechnic University
    Inventors: Albert Sun-chi Chan, Johnny Cheuk-on Tang, Kim-hung Lam, Chung-hin Chui, Stanton Hon-lung Kok, Sau Hing Chan, Filly Cheung, Roberto Gambari, Chor Hing Cheng
  • Patent number: 9260466
    Abstract: A method for suppressing activation of pancreatic stellate cells of a subject includes administering a composition comprising a therapeutically effective amount of Eruberin A. A method of preventing, alleviating or treating pancreatic tumors or pancreatic tumors related diseases includes administering a composition comprising a therapeutically effective amount of Eruberin A. The Eruberin A may be extracted from Pronephrium penangianum.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: February 16, 2016
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Hongjie Zhang, Yegao Chen, Aiping Lu, Albert Sun-Chi Chan, Hongxi Xu, Shilin Chen, Dajian Yang
  • Patent number: 9120816
    Abstract: The present invention relates to chemical entities originated from natural sources and further synthesized for therapeutic uses. More particularly, the present invention relates to norcantharidin analogs synthesized by a transition metal-catalyzed alkynylation of oxanorbornadiene derivatives and their antitumor effects.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: September 1, 2015
    Assignee: HONG KONG BAPTIST UNIVERSITY
    Inventors: Zhaoxiang Bian, Chengyuan Lin, Baomin Fan, Huaixue Mu, Yongyun Zhou, Weimin Zeng, Aiping Lu, Albert Sun Chi Chan
  • Publication number: 20150231090
    Abstract: The present invention provides composition for treating cancer comprising polyprenylated acylphloroglucinol (PPAP) compound. The present invention also provides a composition comprising Guttiferone K for treating esophageal cancer and liver cancer. The present invention further provides a method of using said compound for inhibiting cancer metastasis.
    Type: Application
    Filed: May 1, 2015
    Publication date: August 20, 2015
    Inventors: Hongxi XU, Kaikai SHEN, Yuanzhi LAO, Hongsheng TAN, Kaixian CHEN, Dajian YANG, Shilin CHEN, Zhaoxiang BIAN, Chengyuan LIN, Aiping LU, Albert Sun Chi CHAN
  • Patent number: 9044502
    Abstract: This invention relates to a Chinese medicinal formulation for the treatment of inflammatory bowel diseases, and a method of preparation thereof. The formulation comprises herbal components selected from a group consisting of Radix Codonopsis (Dangshen), Rhizoma Atractylodis Macrocephalae (Bai Zhu), Sclerotium Poriae Cocos (Fu Ling), Rhizoma Zingiberis Officinalis (Gan Jiang), Radix Paeoniae Alba (Bai Shao) and Rhizoma Coptidis (Huanglian).
    Type: Grant
    Filed: September 18, 2013
    Date of Patent: June 2, 2015
    Assignee: Hong Kong Baptist University
    Inventors: Zhaoxiang Bian, Siu Wai Tsang, Siu Po Ip, Che Yuen Justin Wu, Aiping Lu, Albert Sun Chi Chan