Abstract: The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.

Abstract: An image generator is organized into a plurality of rendering engines, each of which renders an image of a part scene and provides the part image to a merge engine associated with that rendering engine. The image is a part image in that it usually contains less than all of the objects in the image to be rendered. The merge engine merges the part image from its associated rendering engine with the part image provided by a prior merge engine and provides the merged part image to a next merge engine. One or more merge engines are designated the output merge engines and these output merge engines output a merged part image that is (a portion of) the ultimate output of the image generator, the full rendered image. Each merge engine performs its merge process on the pixels it has from its rendering engine and from its prior neighbor merge engine, in a pipelined manner and without necessarily waiting for all of the pixels of the part image or the merged part image.

Abstract: An image generator is organized into a plurality of rendering engines, each of which renders an image of a part scene and provides the part image to a merge engine associated with that rendering engine. The image is a part image in that it usually contains less than all of the objects in the image to be rendered. The merge engine merges the part image from its associated rendering engine with the part image provided by a prior merge engine and provides the merged part image to a next merge engine. One or more merge engines are designated the output merge engines and these output merge engines output a merged part image that is (a portion of) the ultimate output of the image generator, the full rendered image. Each merge engine performs its merge process on the pixels it has from its rendering engine and from its prior neighbor merge engine, in a pipelined manner and without necessarily waiting for all of the pixels of the part image or the merged part image.

Abstract: A system and method for creating and using custom activities in a process flow is disclosed. A process flow may include a plurality of default activities that are internal to a process manager. Methods and systems consistent with features of the present invention enable custom activities to be created and used by the process manager to allow data or programming logic located outside of the process manager to be used. A custom activity may be created by: writing and compiling a Java™ class that implements a particular interface; defining an XML description file; (3) packaging the Java class and XML description file into an archive file; and (4) associating the archive file with a custom activity that may be brought into the process flow managed by the process manager.

Abstract: A method of creating and defining a custom data field within a process management system includes creating a file to specify visible field properties of the custom data field and defining a model of the custom data field. The file and the model may be packaged into an archive file. The custom data field may be inserted and the archive file is added into the process management system as a new class. The process management system may be deployed with the new class and the process management system may be tested with the new class.

Abstract: Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.

Abstract: Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.

Abstract: A method of amplifying a mixture of different-sequence DNA fragments which may be formed from RNA transcription, or derived from genomic single- or double-stranded DNA fragments. The fragments are treated with terminal deoxynucleotide transferase and a selected deoxynucleotide, to form a homopolymer tail at the 3' end of the anti-sense strands, and the sense strands are provided with a common 3'-end sequence. The fragments are mixed with a homopolymer primer which is homologous to the homopolymer tail of the anti-sense strands, and a defined-sequence primer which is homologous to the sense-strand common 3'-end sequence, with repeated cycles of fragment denaturation, annealing, and polymerization, to amplify the fragments. In one embodiment, the defined-sequence and homopolymer primers are the same, i.e., only one primer is used. The primers may contain selected restriction-site sequences, to provide directional restriction sites at the ends of the amplified fragments.

Abstract: Viral proteins derived from an enterically transmitted non-A/non-B viral hepatitis agent (HEV) are disclosed. In one embodiment, the protein is immunologically reactive with antibodies present in individuals infected with the viral hepatitis agent. This protein is useful in a diagnostic method for detecting infection by the enterically transmitted agent. Specific epitopes have been identified that are reactive with sera of individual infected with different strains of HEV. Also disclosed are DNA probes derived from a cloned sequence of the viral agent. These probes are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, by using probe-specific amplification of virus-derived DNA fragments.

Abstract: Nucleic acid sequences derived from enterically transmitted nonA/nonB viral hepatitis agent (HEV) are disclosed. DNA sequences encoding specific epitopes within viral protein sequences that are reactive with sera of individuals infected with different strains of HEV are also disclosed. These DNA sequences and fragments thereof are useful for identifying and sequencing the entire viral agent and for assaying the presence of the viral agent in an infected sample, for example by using specific amplification of virus-derived DNA sequences, as well as for producing viral proteins or polypeptides.