Abstract: The invention relates to compounds of formula (I): or a salt or solvate thereof, wherein the variables are as described herein. Compounds of formula (I) and pharmaceutical compositions thereof are antagonists of toll-like receptors such as TLR7, TLR8 and/or TLR9 that are useful for inhibiting immune response and treating diseases associated with undesirable immune response.

Abstract: The present invention relates to a method of treating subjects with diabetic nephropathy by administering certain dosages of Compound I, a stimulator of soluble guanylate cyclase (sGC), either alone or in combination therapy.

Abstract: Described herein are neuroactive steroids of the Formula (II): or a pharmaceutically acceptable salt thereof; wherein A, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5, R6 and are as defined herein. Such compounds are envisioned, in certain embodiments, to behave as GABA modulators. The present invention also provides pharmaceutical compositions comprising a compound of the present invention and methods of use and treatment, e.g., such for inducing sedation and/or anesthesia.

Abstract: Provided herein are 19-nor C3, 3-disubstituted steroids of Formula (I): and pharmaceutically acceptable salts thereof; wherein R1, R2, R3, and R4 are as defined herein, and A is a heteroaryl ring system comprising 3 or 4 nitrogens as defined herein. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, convulsive disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, and tinnitus.

Abstract: Provided herein are 3,3-disubstituted 19-nor-steroidal compounds according to Formula (I): and pharmaceutical compositions thereof. Such compounds are contemplated useful for the prevention and treatment of a variety of CNS-related conditions, for example, treatment of sleep disorders, mood disorders, schizophrenia spectrum disorders, disorders of memory and/or cognition, movement disorders, personality disorders, autism spectrum disorders, pain, traumatic brain injury, vascular diseases, substance abuse disorders and/or withdrawal syndromes, tinnitus, status epilepticus.

Abstract: Systems and methods for mesh refinement of finite element analysis simulations employ an analytical modeling program configured to identify a location of contact between two components and a finite element analysis program configured to use the identified location to perform finite element mesh refinement. In this regard, the location of contact (and location of desired mesh refinement) is identified using analytical modeling. Said location of contact is then provided to the finite element analysis program for determining precisely where to perform mesh refinement on the finite element mesh. The finite element analysis program performs a mesh refinement at the exact location of contact between two components to provide for optimized and more efficient finite element analysis.

Abstract: A compact directed energy system is disclosed that is configured to generate directed energy beams. The compact directed energy system includes a radio frequency system configured to provide a directed energy beam in a frequency range between 500 MHz to 20 Ghz.

Abstract: A compact directed energy system is disclosed that is configured to generate directed energy beams. The compact directed energy system includes a radio frequency system configured to provide a directed energy beam in a frequency range between 500 MHz to 20 Ghz.

Abstract: The present invention provides a method of treating a subject with metabolic syndrome by administering a stimulator of soluble guanylate cyclase (sGC) (Compound I) either alone or in combination therapy with a blood glucose lowering (antihyperglycemic or antidiabetes) medication, a blood pressure lowering (anti-hypertensive) medication, an anti-hyperlipidemic medication, or combinations thereof.

Abstract: A camera gimbal is provided having first and second arms, a support connected to the second arm and having an upper end to which a camera may be mounted and a lower end to which a counterweight is connected, and a gearbox including a gear and a rotary damper. The second arm is rotatable relative to the first arm and includes a proximal end portion forming a housing for the gearbox and a distal end portion to which the support is connected. The camera gimbal is purely-mechanical in operation and is without connection to a power source relying solely on gravity acting on a camera mounted on the support and the counterweight to cause rotation of the first arm relative to the second arm to maintain the camera in a relatively level position while the rotary damper damps the rotational movement.

Abstract: The present invention provides dosing regimens of anti-C5 antibodies, such as pozelimab, for treating or preventing C5-associated diseases such as paroxysmal nocturnal hemoglobinuria or CHAPLE disease.

Abstract: A camera gimbal is provided having first and second arms, a support connected to the second arm and having an upper end to which a camera may be mounted and a lower end to which a counterweight is connected, and a gearbox including a gear and a rotary damper. The second arm is rotatable relative to the first arm and includes a proximal end portion forming a housing for the gearbox and a distal end portion to which the support is connected. The camera gimbal is purely-mechanical in operation and is without connection to a power source relying solely on gravity acting on a camera mounted on the support and the counterweight to cause rotation of the first arm relative to the second arm to maintain the camera in a relatively level position while the rotary damper damps the rotational movement.

Abstract: A camera gimbal has a gearbox including a housing containing therein a central main gear secured to a bearing shaft in a fixed-position relative to the bearing shaft and at least one rotary damper secured to the housing at a fixed-location relative to the housing. The at least one rotary damper is engaged with the central main gear in a manner permitting rotation of the at least one rotary damper about a periphery of the main central gear such that the housing rotates about an axis of rotation extending longitudinally through the bearing shaft and the central main gear. A camera-mount extends from the housing. Gravity acting on the mass/weight of the camera and a counterweight causes rotation of the gearbox to maintain the camera in a relatively level position while the at least one rotary damper damps the rotational movement of the gearbox.

Abstract: The present invention provides a method of treating a subject with metabolic syndrome by administering a stimulator of soluble guanylate cyclase (sGC) (Compound I) either alone or in combination therapy with a blood glucose lowering (antihyperglycemic or antidiabetes) medication, a blood pressure lowering (anti-hypertensive) medication, an anti-hyperlipidemic medication, or combinations thereof.

Abstract: A camera gimbal has a gearbox including a housing containing therein a central main gear secured to a bearing shaft in a fixed-position relative to the bearing shaft and at least one rotary damper secured to the housing at a fixed-location relative to the housing. The at least one rotary damper is engaged with the central main gear in a manner permitting rotation of the at least one rotary damper about a periphery of the main central gear such that the housing rotates about an axis of rotation extending longitudinally through the bearing shaft and the central main gear. A camera-mount extends from the housing. Gravity acting on the mass/weight of the camera and a counterweight causes rotation of the gearbox to maintain the camera in a relatively level position while the at least one rotary damper damps the rotational movement of the gearbox.

Abstract: A method includes deploying non-volatile random access memory (NVRAM) coupled to a processor or central processing unit (CPU) core of a computing device as a peripheral device via an input/output (I/O) bus, and providing a NVRAM application programming interface (API) for the CPU core to conduct NVRAM read and write operations. Providing the NVRAM API includes allocating a single memory buffer per command to hold data transferred to or from the NVRAM. The method includes configuring the processor in conjunction with the NVRAM API to set up command queues inside in the host Memory Mapped Input Output (MMIO) space.

Abstract: Devices and methods for the measurement and control of fluid using one or two capacitors are described. The devices use Micro-Electro-Mechanical-Systems (MEMS) and radio-frequency inductive coupling to sense the properties of a fluid in a tube. The single and double capacitor devices may be coupled to shunts implantable in a patient and operable to be interrogated non-invasively. The shunts employing the novel capacitor devices are insensitive to stray signals such as the orientation of a patient's head. The devices are operable to employ a wireless external spectrometer to measure passive subcutaneous components.

Abstract: Devices and methods for the measurement and control of fluid using one or two capacitors are described. The devices use Micro-Electro-Mechanical-Systems (MEMS) and radio-frequency inductive coupling to sense the properties of a fluid in a tube. The single and double capacitor devices may be coupled to shunts implantable in a patient and operable to be interrogated non-invasively. The shunts employing the novel capacitor devices are insensitive to stray signals such as the orientation of a patient's head. The devices are operable to employ a wireless external spectrometer to measure passive subcutaneous components.

Abstract: A vibration-powered impact recording device that harvests power from vibrations that affect the device is provided. The recording device is affixed to an object and includes a vibration limit detection and recordation system. The system can include a suitable part that is fixed to the object, and a mass (or other suitable part) that is less firmly attached, with the relative motion between the two parts producing an electrical voltage. The electrical voltage can be used to power an information storage unit that records the details of the impact and optionally other sensors which record other parameters such as temperature, humidity etc. at the time of impact.

Abstract: A modeling system includes a processor with software that performs static timing analysis (STA) on a design model. STA software executes a static timing analysis (STA) run with shortened clock cycles to model full cycle clock variability. Designers or other entities interpret the results of the shortened STA run data by performing modeling on the output data to generate slack data for design model data paths. STA software executes an STA run with an extended clock cycle to automatically separate half cycle data path (HCDP) slack data from full cycle data path (FCDP) slack data. The full and half cycle clock variability method may automatically adjust slack data for all half cycle data paths (HCDP)s to account for the additional half cycle variation (AHCV) and half cycle clock edge variability that may penalize the design model results in a real hardware implementation.