Abstract: The present invention relates to a method for treating a subject suffering from a liver disease comprising a step of administering said subject with a therapeutically effective amount of an inhibitor of the endoribonuclease activity of IRE1?. Inventors have shown that in livers of tunicamycin-treated BI-1?/? mice aIRE1?-dependent NLRP3 inflammasome activation, an hepatocyte death, a fibrosis and a dysregulated lipid homeostasis that led to liver failure within a week. To test whether the pharmacological inhibition of IRE1? endoribonuclease activity would block the transition to NASH, mice were injected with the small molecule STF-083010 twice a week for 2 weeks towards the end of a 3-month HFD. In BI-1?/? mice, STF-083010 treatment effectively counteracted IRE1? endoribonuclease activity, improving glucose tolerance and rescuing from NASH.

Abstract: The present invention relates to a method for treating a subject suffering from a liver disease comprising a step of administering said subject with a therapeutically effective amount of an inhibitor of the endoribonuclease activity of IRE1?. Inventors have shown that in livers of tunicamycin-treated BI-1?/? mice aIRE1?-dependent NLRP3 inflammasome activation, an hepatocyte death, a fibrosis and a dysregulated lipid homeostasis that led to liver failure within a week. To test whether the pharmacological inhibition of IRE1? endoribonuclease activity would block the transition to NASH, mice were injected with the small molecule STF-083010 twice a week for 2 weeks towards the end of a 3-month HFD. In BI-1?/? mice, STF-083010 treatment effectively counteracted IRE1? endoribonuclease activity, improving glucose tolerance and rescuing from NASH.

Abstract: A light fixture includes a main body, at least a portion of which is generally cylindrical, the main body having an open side, and one or more light sources disposed within the main body. The light fixture further includes one or more mounting rings configured to substantially encircle the main body and configured for mounting the light fixture. A diffuser may be provided, covering the open side of the main body and enclosing the one or more light sources within the light fixture.

Abstract: A retrofit kit for a light fixture includes a light engine and a mounting bracket. In some aspects, a method of installing the retrofit kit in a light fixture includes installing a mounting bracket in a housing of the light fixture, and placing a light engine in a temporary hanging position. In the temporary hanging position, a hook of a first engine flange of the light engine rests on the mounting bracket and a second engine flange of the light engine opposite from the first engine flange is spaced apart from the mounting bracket.

Abstract: A light fixture includes an electronic accessory module such as a wireless communication module, and a clip for mounting the accessory module to a panel of the light fixture. The clip includes features for snapping the accessory module to a panel of the light fixture, for example to a printed circuit board holding light emitting diodes or to a sheet metal panel that is part of the structure of the light fixture. The clip may hold the accessory module electronics away from any metal parts of the light fixture. In the case that the accessory module is a wireless communication module, this spacing may facilitate robust wireless communication.

Abstract: A light fixture includes an electronic accessory module such as a wireless communication module, and a clip for mounting the accessory module to a panel of the light fixture. The clip includes features for snapping the accessory module to a panel of the light fixture, for example to a printed circuit board holding light emitting diodes or to a sheet metal panel that is part of the structure of the light fixture. The clip may hold the accessory module electronics away from any metal parts of the light fixture. In the case that the accessory module is a wireless communication module, this spacing may facilitate robust wireless communication.

Abstract: A light fixture includes a housing and a light trap. The light trap includes a wireless communication module support adapted to removably support a wireless communication module such as a Bluetooth Low Energy (BLE) module on the light trap. A retrofit kit for an existing light fixture includes a light trap and a wireless communication module. The light trap is adapted to span a gap between a housing and an optic of the existing light fixture and includes a wireless communication module support. The wireless communication module is removably supported by the wireless communication module on the light trap.

Abstract: A light fixture includes a main body, at least a portion of which is generally cylindrical, the main body having an open side, and one or more light sources disposed within the main body. The light fixture further includes one or more mounting rings configured to substantially encircle the main body and configured for mounting the light fixture. A diffuser may be provided, covering the open side of the main body and enclosing the one or more light sources within the light fixture.

Abstract: A Bluetooth beacon for a luminaire assembly includes a module and an antenna associated with the module. The Bluetooth beacon is monted such that the antenna is communicatively visible from a light emitting side of the luminaire assembly. The Bluetooth beacon is configured to provide a signal extending a predetermined distance from the luminaire assembly such that a Bluetooth receiver on a user device can receive a signal from the Bluetooth beacon.

Abstract: A Bluetooth beacon for a luminaire assembly includes a module and an antenna associated with the module. The Bluetooth beacon is monted such that the antenna is communicatively visible from a light emitting side of the luminaire assembly. The Bluetooth beacon is configured to provide a signal extending a predetermined distance from the luminaire assembly such that a Bluetooth receiver on a user device can receive a signal from the Bluetooth beacon.

Abstract: A retrofit kit for a light fixture includes a light engine and a mounting bracket. In some aspects, a method of installing the retrofit kit in a light fixture includes installing a mounting bracket in a housing of the light fixture, and placing a light engine in a temporary hanging position. In the temporary hanging position, a hook of a first engine flange of the light engine rests on the mounting bracket and a second engine flange of the light engine opposite from the first engine flange is spaced apart from the mounting bracket.

Abstract: A Bluetooth beacon for a luminaire assembly includes a module and an antenna associated with the module. The Bluetooth beacon is monted such that the antenna is communicatively visible from a light emitting side of the luminaire assembly. The Bluetooth beacon is configured to provide a signal extending a predetermined distance from the luminaire assembly such that a Bluetooth receiver on a user device can receive a signal from the Bluetooth beacon.

Abstract: A Bluetooth beacon for a luminaire assembly includes a module and an antenna associated with the module. The Bluetooth beacon is monted such that the antenna is communicatively visible from a light emitting side of the luminaire assembly. The Bluetooth beacon is configured to provide a signal extending a predetermined distance from the luminaire assembly such that a Bluetooth receiver on a user device can receive a signal from the Bluetooth beacon.