Patents by Inventor Albert V. Thomas

Albert V. Thomas has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for preparing N-demethyl-N-alkyl erythromycin derivatives
    Patent number: 6084079
    Abstract: The claimed invention relates to a novel process of preparing N-demethyl-N-alkyl-4"-deoxy erythromycin A and B. The process comprises protecting the 2'-hydroxy or the 2'- and 11-hydroxy of a N-demethyl-4"-deoxy erythromycin derivative having the formula: ##STR1## where R.sub.b is H or OH, with a silyl protecting group and alkylating the N-position of the desosamine sugar.
    Type: Grant
    Filed: May 15, 1998
    Date of Patent: July 4, 2000
    Inventors: Robert F. Keyes, Hemant H. Patel, Ramiya H. Premchandran, Albert V. Thomas, Anne H. Kemp
  • Hypophosphite deoxygenation reactions in the synthesis of erythromycin derivatives
    Patent number: 6040440
    Abstract: A process for the preparation of 4"-deoxyerythromycins, having the formula: ##STR1## wherein R is H or OH, R.sup.1 is H or loweralkyl, and R.sup.2 is H or CH.sub.3 by treatment of the starting material, 2'-O-acetyl-4"-imidazolylthiocarbamoyl-erythromycin, with a hypophosphite reagent, in a water-miscible protic solvent optionally comprising a phase transfer agent. In a preferred embodiment, the water-miscible solvent is an alcohol and the starting material is reacted with sodium hypophosphite, ACVA and tetra-n-butylammonium hydroxide.
    Type: Grant
    Filed: March 6, 1998
    Date of Patent: March 21, 2000
    Assignee: Abbott Laboratories
    Inventors: Alexandra E. Graham, Albert V. Thomas, Rachel R. P. Yang
  • Process for preparation of N-demethyl-4"-deoxy-erthromycins A and B
    Patent number: 5922849
    Abstract: A process for the preparation of N-demethyl-4"-deoxy-erythromycins A and B, having the formula: ##STR1## wherein R.sup.a is H or OH, by stepwise addition of iodine and base to the N-dimethyl-4"-deoxyerythromycin, preferably, accompanied by sparging with an inert gas.
    Type: Grant
    Filed: November 22, 1996
    Date of Patent: July 13, 1999
    Assignee: Abbott Laboratories
    Inventors: Ramiya H. Premchandran, Albert V. Thomas, Juliette K. Busse, John E. Dete
  • Process for preparation of 4"-deoxyerythromycins A and B
    Patent number: 5760198
    Abstract: A process for the preparation of 4"-deoxyerythromycins, having the formula: ##STR1## wherein R is H or OH, and R.sup.1 is H or loweralkyl by treatment of the 2'-O-acetyl-4"-imidazolylthionocarbonyl-erythromycin starting material with the radical initiator 4,4'-azobis-(4-cyanovaleric acid), H.sub.3 PO.sub.2 and an organic base in a water-miscible solvent and optionally eliminating the 2'-O-acetyl group. In a preferred embodiment, the water-miscible solvent is an alcohol and the deoxygenation and deacetylation is carried out in one step.
    Type: Grant
    Filed: January 17, 1997
    Date of Patent: June 2, 1998
    Assignee: Abbott Laboratories
    Inventors: Shyamal I. Parekh, Alexandra E. Graham, Michael John Dipierro, Albert V. Thomas, David A. Riley
  • Process for the preparation of arylalkynyl-N-hydroxyurea derivatives having lipoxygenase inhibitory activity
    Patent number: 5714633
    Abstract: The present invention provides a process for the preparation of a compound of formula ##STR1## wherein R is a straight or branched alkyl group of from one to twelve carbon atoms; M represents hydrogen or a pharmaceutically acceptable cation; and A is selected from optionally substituted carbocyclic phenyl.
    Type: Grant
    Filed: August 16, 1996
    Date of Patent: February 3, 1998
    Assignee: Abbott Laboratories
    Inventors: Sanjay R. Chemburkar, Hemantkumar H. Patel, David P. Sawick, Albert V. Thomas
  • Monosaccharides having anti-proliferation and anti-inflammatory activity, compositions and uses thereof
    Patent number: 5298494
    Abstract: Derivatives of simple monosaccharides which exhibit anti-proliferative and/or anti-inflammatory activity and are useful for treating mammals having inflammatory disorders and/or autoimmune disorders. This invention also encompasses pharmaceutical compositions containing these compounds and methods of treating inflammatory and/or autoimmune disorders.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: March 29, 1994
    Assignee: Greenwich Pharmaceuticals Incorporated
    Inventors: Sudershan K. Arora, Roy L. Whistler, Albert V. Thomas
  • 3,5,6-substituted derivatives of 1,2-O-isopropylidene-.alpha.,D-glucofuranose and intermediates for preparing these derivatives
    Patent number: 5010058
    Abstract: Derivatives of 1,2-O-isopropylidene-.alpha.,D-glucofuranose and intermediates for preparing these derivatives are described. These derivatives are useful for treating animals and mammals with inflammatory and/or autoimmune disorders such as autoimmune deficiency syndrome, psoriasis, atopic dermatitus, rheumatoid arthritis, osteoarthritis, scleroderma and systemic lupus erythematosus.
    Type: Grant
    Filed: June 22, 1989
    Date of Patent: April 23, 1991
    Assignee: 501 Greenwich Pharmaceuticals Incorporated
    Inventors: Bruce Ronsen, Sudershan K. Arora, Albert V. Thomas
  • Derivatives of .alpha.,D-glucofuranose or .alpha.,D-allofuranose and intermediates for preparing these derivatives
    Patent number: 4996195
    Abstract: Derivatives of -.alpha.,D-glucofuranose .alpha.,D-allanfuranose and intermediates for preparing these derivatives are described. These derivatives are useful for treating animals and mammals with inflammatory and/or autoimmune disorders such as psoriasis, atopic dermatitus, rheumatoid arthritis, osterarthritis, scleroderma and systemic lupus erythematosus.
    Type: Grant
    Filed: January 9, 1989
    Date of Patent: February 26, 1991
    Assignee: Greenwich Pharmaceuticals Inc.
    Inventors: Bruce Ronsen, Sudershan K. Arora, Albert V. Thomas