Patents by Inventor Albert Van Den Berg
Albert Van Den Berg has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240132972Abstract: The invention provides in vitro methods of determining whether an individual has a pre-cancer or cancer comprising determining the presence or absence of one or more methylation markers of a methylation marker set in a urine sample of said individual; and determining whether the individual has pre-cancer or cancer based on the detection of the presence or absence of said one or more methylation markers in the urine sample, wherein the presence of said one or more methylation markers indicates that the individual has pre-cancer or cancer. The invention further provides methods for typing pre-cancer or cancer based on the presence or absence of one or more methylation markers of a methylation marker set in a urine sample.Type: ApplicationFiled: October 29, 2023Publication date: April 25, 2024Inventors: Willem Frederik Rurup, Loes Irene Segerink, Roderik Adriaan Kraaijenhagen, Herbert Michael Pinedo, Albert Van Den Berg, Renske Daniela Maria Steenbergen, Jacobus Adrianus Nieuwenhuijzen, Idris Bahce, Geert Kazemier
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Patent number: 11821040Abstract: The invention provides in vitro methods of determining whether an individual has a pre-cancer or cancer comprising determining the presence or absence of one or more methylation markers of a methylation marker set in a urine sample of said individual; and determining whether the individual has pre-cancer or cancer based on the detection of the presence or absence of said one or more methylation markers in the urine sample, wherein the presence of said one or more methylation markers indicates that the individual has pre-cancer or cancer. The invention further provides methods for typing pre-cancer or cancer based on the the presence or absence of one or more methylation markers of a methylation marker set in a urine sample.Type: GrantFiled: March 31, 2017Date of Patent: November 21, 2023Assignee: Nanomed Diagnostics BVInventors: Willem Frederik Rurup, Loes Irene Segerink, Roderik Adriaan Kraaijenhagen, Herbert Michael Pinedo, Albert Van Den Berg, Renske Daniëla Maria Steenbergen, Jacobus Adrianus Nieuwenhuijzen, Idris Bahce, Geert Kazemier
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Patent number: 10879039Abstract: A method of charge mitigation in additive layer manufacturing is provided, which uses a charged particle beam (103) to fuse metal powder (122) within a metal powder bed (123) to form a product layer-by-layer, the method comprising using a charged particle beam optical system to form a charged particle beam, to steer the charged particle beam to be incident on a powder bed of metal powder and to scan over the powder bed to fuse powder into a desired layer shape. While steering the charged particle beam, the method comprises using a neutralising particle source (160) to generate neutralising particles of an opposite charge to the charged particles in the vicinity of the charged particle beam such that the neutralising particles are attracted to the charged particles of powder in the powder bed. An additive layer manufacturing apparatus (100) is also provided.Type: GrantFiled: December 15, 2017Date of Patent: December 29, 2020Assignee: RELIANCE PRECISION LIMITEDInventors: Jakob Albert Van Den Berg, Martyn James Hussey, William Thomas Richardson, Ian Laidler
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Patent number: 10670508Abstract: The invention provides a system (1) for performing sperm analysis and selection based on sperm cell morphology of sperm cells (6) in a fluid (5), the system (1) comprising: (i) a fluid flow channel (2) for transport of said fluid (5), the fluid flow channel (2) comprising an inlet (10) an analyzing zone (40) configured downstream from said inlet (10) and comprising a first pair of electrodes (41) comprising a first intra-electrode distance (dl), a sorting zone (50) configured downstream from said analyzing zone (40) and comprising a sorting device (51), and outlets (80, 90, . . .Type: GrantFiled: September 30, 2016Date of Patent: June 2, 2020Assignee: SEMEN REFINEMENT B.V.Inventors: Bjorn de Wagenaar, Loes Irene Segerink, Wouter Olthuis, Adrianus Joseph Sprenkels, Albert van den Berg
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Publication number: 20190362936Abstract: A method of charge mitigation in additive layer manufacturing is provided, which uses a charged particle beam (103) to fuse metal powder (122) within a metal powder bed (123) to form a product layer-by-layer, the method comprising using a charged particle beam optical system to form a charged particle beam, to steer the charged particle beam to be incident on a powder bed of metal powder and to scan over the powder bed to fuse powder into a desired layer shape. While steering the charged particle beam, the method comprises using a neutralising particle source (160) to generate neutralising particles of an opposite charge to the charged particles in the vicinity of the charged particle beam such that the neutralising particles are attracted to the charged particles of powder in the powder bed. An additive layer manufacturing apparatus (100) is also provided.Type: ApplicationFiled: December 15, 2017Publication date: November 28, 2019Inventors: Jakob Albert Van Den Berg, Martyn James Hussey, William Thomas Richardson, Ian Laidler
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Publication number: 20190241963Abstract: The invention provides in vitro methods of determining whether an individual has a pre-cancer or cancer comprising determining the presence or absence of one or more methylation markers of a methylation marker set in a urine sample of said individual; and determining whether the individual has pre-cancer or cancer based on the detection of the presence or absence of said one or more methylation markers in the urine sample, wherein the presence of said one or more methylation markers indicates that the individual has pre-cancer or cancer. The invention further provides methods for typing pre-cancer or cancer based on the the presence or absence of one or more methylation markers of a methylation marker set in a urine sample.Type: ApplicationFiled: March 31, 2017Publication date: August 8, 2019Inventors: Willem Frederik Rurup, Loes Irene Segerink, Roderik Adriaan Kraaijenhagen, Herbert Michael Pinedo, Albert Van Den Berg, Renske Daniëla Maria Steenbergen, Jacobus Adrianus Nieuwenhuijzen, Idris Bahce, Geert Kazemier
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Publication number: 20180266937Abstract: The invention provides a system (1) for performing sperm analysis and selection based on sperm cell morphology of sperm cells (6) in a fluid (5), the system (1) comprising: (i) a fluid flow channel (2) for transport of said fluid (5), the fluid flow channel (2) comprising an inlet (10) an analyzing zone (40) configured downstream from said inlet (10) and comprising a first pair of electrodes (41) comprising a first intra-electrode distance (dl), a sorting zone (50) configured downstream from said analyzing zone (40) and comprising a sorting device (51), and outlets (80, 90, . . .Type: ApplicationFiled: September 30, 2016Publication date: September 20, 2018Applicant: Semen Refinement B.V.Inventors: Bjorn de Wagenaar, Loes Irene Segerink, Wouter Olthuis, Adrianue Joseph Sprenkels, Albert van den Berg
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Patent number: 9689839Abstract: The invention provides a method for the measurement of a concentration of a charged species in a sample, the sample having a plurality of types of charged species and at least one insoluble component. The method comprises: providing the sample on a surface of a partly permeable layer; allowing components of the sample to pass through the partly permeable layer into a channel; and separating the components into sections, such that each at least one of the sections substantially comprises a single type of the plurality of the types of charged species, and determining the charge concentration in the at least one of the sections.Type: GrantFiled: May 16, 2013Date of Patent: June 27, 2017Assignee: CE-MATE B.V.Inventors: Steven S. Staal, Jan Floris, Albert Van Den Berg
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Patent number: 9546117Abstract: A process for the tetramerization of ethylene includes contacting ethylene with a catalyst under ethylene oligomerization conditions. The catalyst comprises a source of chromium, a ligating compound, and an activator. The ligating compound includes a phosphine that forms part of a cyclic structure.Type: GrantFiled: May 6, 2014Date of Patent: January 17, 2017Assignee: Sasol Technology (Proprietary) LimitedInventors: Molise Stephen Mokhadinyana, Munaka Christopher Maumela, Moses Mokgolela Mogorosi, Matthew James Overett, Jan-Albert Van Den Berg, Werner Janse Van Rensburg, Kevin Blann
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Publication number: 20160075616Abstract: A process for the tetramerisation of ethylene includes contacting ethylene with a catalyst under ethylene oligomerisation conditions. The catalyst comprises a source of chromium, a ligating compound, and an activator. The ligating compound includes a phosphine that forms part of a cyclic structure.Type: ApplicationFiled: May 6, 2014Publication date: March 17, 2016Inventors: Molise Stephen MOKHADINYANA, Munaka Christopher MAUMELA, Moses Mokgolela MOGOROSI, Matthew James OVERETT, Jan-Albert VAN DEN BERG, Werner JANSE VAN RENSBURG, Kevin BLANN
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Patent number: 8845535Abstract: The invention relates to a capsule or chip or sensor comprising a marker/detector and signalling device/method associated with the development of a medical condition/disease and to its use. This In Situ Lab On a Chip Signalling device (ISLOGS device) is used for detecting a medical condition/disease in situ or in vivo (inside the body), for example by swallowing it for testing in the digestive tract or by putting it into the vagina, mouth or nose. All reactions takes place in the body and when the test result is positive the device will notify the subject by colorizing the tested body fluid or biomaterial (for example faeces, urine or saliva) or the device itself. The detection is made outside of the body when the biomaterial or ISLOCS device has left the body.Type: GrantFiled: February 23, 2009Date of Patent: September 30, 2014Assignees: Universiteit TwenteInventors: Herbert Michael Pinedo, Roderik Adriaan Kraaijenhagen, Albert Van Den Berg
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Publication number: 20140021065Abstract: The invention relates to a device for the measurement of hydrogen peroxide and optionally other biomarkers in a gaseous mixture, and in particular to a microfabricated device. The device comprises hydrogen peroxide capturing means and an electromechanical sensor comprising a sensing element in direct contact with the capturing means. The device further comprises means to measure the potential of the sensing element and/or the current through it as a result of a changing hydrogen peroxide concentration in the gaseous mixture. The device also comprises cooling/heating means for cooling and/or heating the capturing means. The device is preferably applied for online measurement of the hydrogen peroxide content in exhaled air.Type: ApplicationFiled: November 18, 2011Publication date: January 23, 2014Applicant: SENZAIR B.V.Inventors: Justyna Wiedemair, Wouter Olthuis, Albert Van Den Berg
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Publication number: 20130319860Abstract: The invention provides a method for the measurement of a concentration of a charged species in a sample, the sample having a plurality of types of charged species and at least one insoluble component. The method comprises: providing the sample on a surface of a partly permeable layer; allowing components of the sample to pass through the partly permeable layer into a channel; and separating the components into sections, such that each at least one of the sections substantially comprises a single type of the plurality of the types of charged species, and determining the charge concentration in the at least one of the sections.Type: ApplicationFiled: May 16, 2013Publication date: December 5, 2013Applicant: Medimate Holding B.V.Inventors: Steven S. Staal, Jan Floris, Albert Van Den Berg
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Publication number: 20130266979Abstract: The invention provides a lab-on-a-chip device comprising a micro channel for a fluid, wherein the micro channel comprises a circumferential channel wall, wherein the channel wall comprises a first electrode, a second electrode, and a floating third electrode. The device can be used in a method for the analysis of an analyte fluid comprising flowing the analyte fluid through the channel of the electronic lab-on-a-chip device by measuring an electric signal between the first and the second electrode, especially measuring the electrical impedance between the first electrode and the second electrode. This may be used for instance for the analyses of mammalian semen.Type: ApplicationFiled: July 21, 2011Publication date: October 10, 2013Applicant: Stichting voor de Technische WetenschappenInventors: Loes Irene Segerink, Adrianus Joseph Sprenkels, Johan Gerrit Bomer, Albert van den Berg
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Patent number: 8465637Abstract: The invention provides a method for the measurement of a concentration of a charged species in a sample, the sample having a plurality of types of charged species and at least one insoluble component. The method comprises: providing the sample on a surface of a partly permeable layer (30); allowing components of the sample to pass through the partly permeable layer (30) into a channel (12); and separating the components into sections, such that each at least one of the sections substantially comprises a single type of the plurality of the types of charged species, and determining the charge concentration in the at least one of the sections.Type: GrantFiled: November 21, 2006Date of Patent: June 18, 2013Assignee: Medimate Holding B.V.Inventors: Steven Selwyn Staal, Jan Floris, Albert Van Den Berg
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Publication number: 20120202325Abstract: A method for manufacturing a single crystal nano-structure includes providing a device layer with a 100 structure on a substrate; providing a stress layer onto the device layer; patterning the stress layer along the 110 direction of the device layer; selectively removing parts of the stress layer to obtain exposed parts of the device layer; plane dependent etching of the exposed parts of the device layer to obtain an exposed 111 faces of the device layer; thermally oxidizing the exposed 111 face of the device layer and forming a lateral oxidation layer at an interface of the device layer and the stress layer; providing a mask layer onto the oxidized exposed 111 face of the device layer; removing remaining parts of the stress layer to obtain further exposed parts of the device layer; removing the mask layer; plane dependent etching of the further exposed parts of the device layer to form a single crystal nano-structure with a triangular shaped cross section, until a side of the triangular shaped cross sectionType: ApplicationFiled: August 16, 2010Publication date: August 9, 2012Applicant: UNIVERSITEIT TWENTEInventors: Albert van den Berg, Johan Bomer, Edwin Thomas Carlen, Songyue Chen, Roderik Adriaan Kraaijenhagen, Herbert Michael Pinedo
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Publication number: 20110123977Abstract: The invention provides a method for taking a plurality of samples (200) from a substrate (40) with sample material (20) by using an optical microscope (1000) and a stamp (50). At least part of the stamp (50) is transparent and the stamp (50) is arranged in front of the objective (41). The elevations (58) of the stamp (50) are contacted with sample material (20) in a substrate (40). The samples (200) may be replicated to other substrates.Type: ApplicationFiled: December 19, 2008Publication date: May 26, 2011Applicant: DSM IP Assets B.V.Inventors: Adrianus Joseph Sprenkels, Johan Gerrit Bomer, Colin John Ingham, Johannes Epeüs Theodoor Van Hylckama Vlieg, Willem Meindert De Vos, Albert Van Den Berg
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Publication number: 20110046458Abstract: The invention relates to a capsule or chip or sensor comprising a marker/detector and signalling device/method associated with the development of a medical condition/disease and to its use. This In Situ Lab On a Chip Signalling device (ISLOGS device) is used for detecting a medical condition/disease in situ or in vivo (inside the body), for example by swallowing it for testing in the digestive tract or by putting it into the vagina, mouth or nose. All reactions takes place in the body and when the test result is positive the device will notify the subject by colorizing the tested body fluid or biomaterial (for example faeces, urine or saliva) or the device itself. The detection is made outside of the body when the biomaterial or ISLOCS device has left the body.Type: ApplicationFiled: February 23, 2009Publication date: February 24, 2011Inventors: Herbert Michael Pinedo, Roderik Adriaan Kraaijenhagen, Albert Van Den Berg
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Publication number: 20100062082Abstract: The invention provides a method for the measurement of a concentration of a charged species in a sample, the sample having a plurality of types of charged species and at least one insoluble component. The method comprises: providing the sample on a surface of a partly permeable layer (30); allowing components of the sample to pass through the partly permeable layer (30) into a channel (12); and separating the components into sections, such that each at least one of the sections substantially comprises a single type of the plurality of the types of charged species, and determining the charge concentration in the at least one of the sections.Type: ApplicationFiled: November 21, 2006Publication date: March 11, 2010Inventors: Steven Selwyn Staal, Jan Floris, Albert Van Den Berg
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Publication number: 20100031730Abstract: The invention relates to a device for measuring the ammonia content in a gas mixture. The device comprises at least one inlet and one outlet for the gas mixture, between which is situated an ammonia measuring system connected thereto. The device also comprises first regulating means for regulating the gas mixture flow through the inlet, and second means which are adapted such that they allow a measurement of the ammonia content which is substantially independent of the gas mixture flow rate. The device is preferably applied for measuring the ammonia content in exhaled air.Type: ApplicationFiled: November 9, 2007Publication date: February 11, 2010Inventors: Iris Van Uitert, Wouter Olthuis, Albert Van Den Berg