Abstract: The invention relates to single chamber containers with internal indentions having rigid, semi-flexible and/or collapsible walls, upon which flexible seals are placed to form separate compartments. Between these compartments is a rigid, semi-flexible and/or collapsible section that may have optional cutting rings welded. By applying pressure and/or suction on one or more of the container portions, the seal is either pressure or mechanically broken. After a quick agitation, the consumer simply opens the discharge end and is ready to enjoy an instantly mixed beverage.

Abstract: A device for measuring blind holes formed through a bone includes (a) a first elongated rod including a shaft extending from a proximal end to a distal end, the distal end including an increased diameter abutment extending radially outward therefrom, the abutment including a proximal surface formed to contact a portion of the bone adjacent a distal opening of the blind hole to assume a locked configuration with the bone and (b) a second elongated rod extending from a proximal end to a distal end along a longitudinal axis.

Abstract: A request to establish a voice communications session between a user of a telephonic device and an interactive voice response (IVR) system of a call handling system is received by a dynamic call control engine. A resource requirement for the voice communications session is determined. Resource usage data for multiple call handling systems is accessed by the dynamic call control engine. A particular call handling system from among the multiple call handling systems is selected based on the resource usage data and the resource requirement. A connection to be set up between the telephonic device and the particular call handling system to allow the user of the telephonic device to participate in the voice communications session with an IVR system of the particular call handling system is enabled.

Abstract: Provided herein are compositions, methods, and uses involving antibodies that immunospecifically bind glycosylated forms of MUC16, a tethered mucin protein. Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer.

Abstract: A device for measuring blind holes formed through a bone includes (a) a first elongated rod including a shaft extending from a proximal end to a distal end, the distal end including an increased diameter abutment extending radially outward therefrom, the abutment including a proximal surface formed to contact a portion of the bone adjacent a distal opening of the blind hole to assume a locked configuration with the bone and (b) a second elongated rod extending from a proximal end to a distal end along a longitudinal axis.

Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

Abstract: A request to establish a voice communications session between a user of a telephonic device and an interactive voice response (IVR) system of a call handling system is received by a dynamic call control engine. A resource requirement for the voice communications session is determined. Resource usage data for multiple call handling systems is accessed by the dynamic call control engine. A particular call handling system from among the multiple call handling systems is selected based on the resource usage data and the resource requirement. A connection to be set up between the telephonic device and the particular call handling system to allow the user of the telephonic device to participate in the voice communications session with an IVR system of the particular call handling system is enabled.

Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.

Abstract: Cable and crimp assembly kits for fixing bone fractures include long-nose crimp pliers that have a pair of operating handles and connected opposed long jaws. The long jaws are designed to hold and crush a wire crimp. The jaws are long and narrow enough to be able to insert and crush a crimp through a small incision, such as used by a known wire passer tool, at a deeply located bone without spreading or opening wider the small incision. The long-nosed pliers can be used with a crimp alone or with a crimp and an intermediate part that provisionally holds a tension applied to an associated cable or wire.

Abstract: An apparatus for securing a cerclage member about a bone within a living body comprises a crimp including a first space extending longitudinally therethrough from a first space proximal opening to a first space distal opening, the first space sized and shaped to slidably receive a cerclage member therein and a second space extending parallel to the first space from a second space proximal opening to a second space distal opening, the second space including a proximal portion to receive the cerclage member and a distal portion decreasing in cross-sectional area and an insert that, when inserted into the second space distal opening adjacent to a cerclage member, a decreasing cross-sectional area of the second space distal portion forces the insert laterally relative to a longitudinal axis of the second space, pinching and locking the cerclage member against movement relative to the crimp.

Abstract: An apparatus for securing a cerclage member about a bone within a living body comprises a crimp including a first space extending longitudinally therethrough from a first space proximal opening to a first space distal opening, the first space sized and shaped to slidably receive a cerclage member therein and a second space extending parallel to the first space from a second space proximal opening to a second space distal opening, the second space including a proximal portion to receive the cerclage member and a distal portion decreasing in cross-sectional area and an insert that, when inserted into the second space distal opening adjacent to a cerclage member, a decreasing cross-sectional area of the second space distal portion forces the insert laterally relative to a longitudinal axis of the second space, pinching and locking the cerclage member against movement relative to the crimp.

Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

Abstract: A crimp configured to fix a cable about a bone includes a body extending from a proximal end to a distal end and a first channel extending through the body from the proximal end to the distal end, the first channel being sized and shaped to permit a cable to be slid therethrough along with a second channel extending through the body from the proximal end to the distal end, the second channel being sized and shaped to permit a cable to be slid therethrough and a deformable extension attached to the proximal end of the body, the extension including a lumen aligned with the second channel and sized and shaped to permit the cable to be slid therethrough.

Abstract: A device for the positioning of a bone plate against a bone comprises first and second arms pivotally connected at a first joint, distal ends of the first and second arms defining a gripping surface for gripping the bone therebetween, proximal portions of the first and second arms extending in a first plane. An extension member couples to the first and second arms at the first joint and includes a first section extending distally from the first joint parallel to the first plane and a second section extending distally from the first section angled relative to the first section so that when the first and second arms are in a desired configuration gripping the bone, the second section extends parallel to the bone. A compression mechanism couples to the second section and includes a compression member and a coupling member being movable toward and away from the second section.

Abstract: A crimp configured to fix a cable about a bone includes a body extending from a proximal end to a distal end and a first channel extending through the body from the proximal end to the distal end, the first channel being sized and shaped to permit a cable to be slid therethrough along with a second channel extending through the body from the proximal end to the distal end, the second channel being sized and shaped to permit a cable to be slid therethrough and a deformable extension attached to the proximal end of the body, the extension including a lumen aligned with the second channel and sized and shaped to permit the cable to be slid therethrough.

Abstract: Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.

Abstract: A device for guiding a depth gauge for measuring blind holes formed through a bone including (a) a handle having an elongated body, an upper surface of the body having a peg extending therefrom to removably engage a proximal end of a first elongated rod of the depth gauge, the handle including a first slot extending into the upper surface and open to a first elongated channel extending through the handle and (b) a first elongated shaft extending through the first elongated channel and including a first tab extending through the first slot, a range of movement of the first elongated shaft relative to the handle being limited by engagement of the first tab with walls of the first slot. In an operative configuration, the slotted tab receives a proximal end of the depth gauge to control movement of an increased diameter insert at a distal end thereof.

Abstract: A device for binding a cable about a fractured bone to stabilize a fracture includes a slot including a distal opening sized to receive an enlarged end of a cable and a proximal opening sized to permit the cable to slide therethrough while preventing the enlarged end from passing therethough and a bore sized to slidably receive the cable, the bore extending to a proximal opening in combination with a locking element channel extending to a distal end opening into the bore and a locking element movable into a locking position in which a distal end of the locking element extends into the bore to engage a portion of the cable received therein and lock the cable in a desired position within the bore.