Abstract: A portable multi-sensor device includes a substantially sheet-like and at least partially flexible unit support element, a garment to be worn by a user and to be removably associated with the support element, a plurality of sensors, adapted to detect biological and/or vital parameters on the body of a user and transduce them into electric signals, at least one of which is incorporated in the unit support element, a transceiver for remote transmission of the electric signals to a remote monitoring center, a processing and control unit for processing and controlling the electric signals, therapeutic treatment elements associated with the unit support element and designed to contact one part of the wearer's body. The therapeutic treatment elements are electrically connected to the processing and control unit to be controlled thereby and to provide therapeutic and/or thermal therapeutic treatment to an area of the body.