Patents by Inventor Alberto Epstein

Alberto Epstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240132897
    Abstract: The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting/silencing neurotransmission or synaptic transmission of afferent neurons.
    Type: Application
    Filed: December 11, 2023
    Publication date: April 25, 2024
    Inventors: François GIULIANO, Alberto EPSTEIN, Olivier LE COZ, Alejandro ARANDA
  • Publication number: 20230134548
    Abstract: The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting/silencing neurotransmission or synaptic transmission of afferent neurons.
    Type: Application
    Filed: July 15, 2022
    Publication date: May 4, 2023
    Applicants: UNIVERSITE DE VERSAILLES-ST QUENTIN EN YVELINES, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
    Inventors: François GIULIANO, Alberto EPSTEIN, Olivier LE COZ, Alejandro ARANDA
  • Patent number: 11414666
    Abstract: The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting/silencing neurotransmission or synaptic transmission of afferent neurons.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: August 16, 2022
    Assignees: UNIVERSITE DE VERSAILLES-ST QUENTIN EN YVELINES, ASSISTANCE PUBLIQUE—HOPITAUX DE PARIS
    Inventors: François Giuliano, Alberto Epstein, Olivier Le Coz, Alejandro Aranda
  • Publication number: 20200071703
    Abstract: The present invention provides a method and a pharmaceutical composition for the treatment of the NDO comprising the viral expression vector carrying a transcription cassette that harbors transgene(s) inhibiting/silencing neurotransmission or synaptic transmission of afferent neurons.
    Type: Application
    Filed: June 23, 2017
    Publication date: March 5, 2020
    Applicants: UNIVERSITE DE VERSAILLES-ST QUENTIN EN YVELINES, ASSISTANCE PUBLIQUE - HOPITAUX DE PARIS
    Inventors: François GIULIANO, Alberto EPSTEIN, Olivier LE COZ, Alejandro ARANDA
  • Publication number: 20070280963
    Abstract: Improved methods for making non-cytotoxic helper virus-free preparations of herpes virus amplicon vectors or particles, the vectors themselves, recombinant helper virus and cells and methods of using same to treat patients and as tools in therapy and prevention, immunology, molecular biology, biotechnology and genetic engineering. In one embodiment, an amplicon plasmid vector contains at least one transgene that encodes a transgene product which is an interfering RNA molecule that can be converted into a siRNA by the cell machinery.
    Type: Application
    Filed: May 17, 2004
    Publication date: December 6, 2007
    Inventors: Alberto Epstein, Cecile Zaupa, Carine Logvinoff, Patrick Lomonte, Joelle Thomas
  • Publication number: 20040229362
    Abstract: A defective Cre-loxP based helper virus (HSV-1 LaL&Dgr;J), which genome is of reduced size and is free of the genes encoding ICP4 and ICP34.5 proteins from the helper genome, in addition to the native “a” signals. HSV-1 LaL&Dgr;J carries a single floxed “a” signal in gC locus. To produce HSV-1 LaL&Dgr;J and to prepare the amplicon vectors, two novel cell lines expressing the essential ICP4 protein, either alone or in combination to Cre recombinase, are also disclosed. These cell lines complement ICP4 while minimizing the probability of generating replication-competent particles. The novel helper system enables production of large amounts of high-titer amplicon vectors. Residual helper particles generated do not exceed 0.5% of the viral population and can grow only in cells expressing ICP4. Amplicon vectors produced with this method showed no cytotoxicity for infected cells.
    Type: Application
    Filed: May 15, 2003
    Publication date: November 18, 2004
    Inventors: Alberto Epstein, Cecile Zaupa, Carine Logvinoff