Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Abstract: A patient simulator and corresponding method, according to which a control system and a simulated spine assembly are adapted to simulate human spinal motion. The simulated spine assembly includes a plurality of pivoting joints connected together. In one or more embodiments, the simulated spine assembly further includes one or more encoders adapted to monitor one or more relative positions of the plurality of pivoting joints, and to communicate the monitored one or more relative positions to the control system. In addition, or instead, in one or more embodiments, the simulated spine assembly further includes one or more sensors adapted to monitor one or more forces being applied to one or more of the plurality of pivoting joints, and to communicate the monitored one or more forces to the control system.

Abstract: A method for devatting the grape harvest and a device for devatting a grape harvest via the pressurized injection of air or other gases in a controlled manner into self-emptying wine making vats or similar, for the purpose of emptying the grape harvest once the maceration thereof has been completed, after the homogenization of the mixture, transferring the liquid portion to another tank and the crushed grape pulp to the press, thereby obtaining a solid phase (pomace) as a waste product which can be used to produce associated products.

Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Abstract: The present invention relates to a method for producing mixtures of hydrocarbons and aromatic compounds, for use as fuel components (preferably in the range C5-C16), by means of catalytic conversion of the oxygenated organic compounds contained in aqueous fractions derived from biomass treatments, wherein said method can comprise at least the following steps: (i) bringing the aqueous mixture containing the oxygenated organic compounds derived from biomass in contact with a catalyst comprising at least Sn and Nb, Sn and Ti, and combinations of Sn, Ti and Nb; (ii) reacting the mixture with the catalyst in a catalytic reactor at temperatures between 100 and 350° C. and under pressures from 1 to 80 bar in the absence of hydrogen; and (iii) recovering the products obtained by means of the liquid/liquid separation of the aqueous and organic phases.

Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.

Abstract: The present application relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, and intermediates thereto. The application also provides pharmaceutical compositions comprising compounds of the present invention and methods of using said compounds or compositions in the treatment of and immunization for infectious diseases.

Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.

Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

Abstract: A number of triterpene saponin variants with different modifications on their central glycosyl ester linkage are described. Also described are methods of making and method of using such triterpene saponin variants.

Abstract: An exhaust finisher assembly for a vehicle includes an exhaust finisher and a deflector. The exhaust finisher is configured to be connected to a rear bumper fascia of the vehicle. The deflector is connected to the exhaust finisher. The deflector includes a first portion connected to the exhaust finisher and a second portion extending outwardly from the first portion.

Abstract: Provided herein are compositions, methods, and uses involving antibodies that immunospecifically bind glycosylated forms of MUC16, a tethered mucin protein. Also provided herein are uses and methods for managing, treating, or preventing disorders, such as cancer.

Abstract: The present invention relates to triterpene glycoside saponin-derived adjuvants, syntheses thereof, intermediates thereto, and uses thereof. QS-7 is a potent immuno-adjuvant that is significantly less toxic than QS-21, a related saponin that is currently the favored adjuvant in anticancer and antiviral vaccines. Tedious isolation and purification protocols have hindered the clinical development of QS-7. A novel semi-synthetic method is provided wherein a hydrolyzed prosapogenin mixture is used to synthesize QS-7, QS-21, and related analogs, greatly facilitating access to QS-7 and QS-21 analogs for preclinical and clinical evaluation.

Abstract: Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.

Abstract: A bone plate system for internal fixation of bone fractures includes a bone plate having a plurality of bone plate holes. The holes are constructed to receive either a non-locking, locking, or variable-angle locking bone screw. The holes have discrete columns of teeth or thread segments arranged around the inner surface of the hole for engaging threads on the heads of locking and variable-angle locking bone screws. Conventional locking bone screws engage the bone plate coaxially with the central axis of the bone plate hole. Variable-angle locking bone screws can engage the bone plate at a selectable angle within a range of selectable angles relative to the central axis of the bone plate hole. The head of the variable-angle locking screw is at least partially spherical, and the thread thereon has a profile that follows the arc-shaped radius of curvature of the spherical portion of the screwhead.

Abstract: Truncated triterpene saponin analogues containing a trisaccharide or tetrasaccharide ester are disclosed. Also disclosed are pharmaceutical compositions comprising truncated saponin analogues and synthetic methods of producing the truncated saponin analogues. Another aspect of the present application relates to a method for immunizing a subject, comprising administering to the subject the pharmaceutical composition comprising a minimal saponin analogue and an antigen.

Abstract: An exhaust finisher assembly for a vehicle includes an exhaust finisher and a deflector. The exhaust finisher is configured to be connected to a rear bumper fascia of the vehicle. The deflector is connected to the exhaust finisher. The deflector includes a first portion connected to the exhaust finisher and a second portion extending outwardly from the first portion.

Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.

Abstract: The present invention relates to a method for producing mixtures of hydrocarbons and aromatic compounds, for use as fuel components (preferably in the range C5-C16), by means of catalytic conversion of the oxygenated organic compounds contained in aqueous fractions derived from biomass treatments, wherein said method can comprise at least the following steps: (i) bringing the aqueous mixture containing the oxygenated organic compounds derived from biomass in contact with a catalyst comprising at least Sn and Nb, Sn and Ti, and combinations of Sn, Ti and Nb; (ii) reacting the mixture with the catalyst in a catalytic reactor at temperatures between 100 and 350° C. and under pressures from 1 to 80 bar in the absence of hydrogen; and (iii) recovering the products obtained by means of the liquid/liquid separation of the aqueous and organic phases.

Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.