Patents by Inventor Alberto Fernandez-Nieves
Alberto Fernandez-Nieves has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11766823Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.Type: GrantFiled: April 19, 2021Date of Patent: September 26, 2023Assignee: University of Florida Research Foundation, Inc.Inventors: Thomas Ettor Angelini, Wallace Gregory Sawyer, Kyle Gene Rowe, Tapomoy Bhattacharjee, Alberto Fernandez-Nieves, Ya-Wen Chang, Samantha M. Marquez
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Patent number: 11654612Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.Type: GrantFiled: November 5, 2021Date of Patent: May 23, 2023Assignees: University of Florida Research Foundation, Inc., Georgia Tech Research CorporationInventors: Alberto Fernandez-Nieves, Thomas Ettor Angelini, Ya-Wen Chang, Samantha M. Marquez
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Publication number: 20220055287Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.Type: ApplicationFiled: November 5, 2021Publication date: February 24, 2022Inventors: Alberto Fernandez-Nieves, Thomas Eltor Angelini, Ya-Wen Chang, Samantha M. Marquez
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Patent number: 11192292Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.Type: GrantFiled: December 4, 2015Date of Patent: December 7, 2021Assignees: University of Florida Research Foundation, Inc., Georigia Tech Research CorporationInventors: Alberto Fernandez-Nieves, Thomas Ettor Angelini, Ya-Wen Chang, Samantha M. Marquez
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Publication number: 20210252777Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.Type: ApplicationFiled: April 19, 2021Publication date: August 19, 2021Inventors: Thomas Ettor ANGELINI, Wallace Gregory SAWYER, Kyle Gene ROWE, Tapomoy BHATTACHARJEE, Alberto FERNANDEZ-NIEVES, Ya-Wen CHANG, Samantha M. MARQUEZ
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Patent number: 11007705Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.Type: GrantFiled: February 12, 2016Date of Patent: May 18, 2021Assignees: University of Florida Research Foundation, Inc., Georgia Tech Research CorporationInventors: Thomas Ettor Angelini, Wallace Gregory Sawyer, Kyle Gene Rowe, Tapomoy Bhattacharjee, Alberto Fernandez-Nieves, Ya-Wen Chang, Samantha M. Marquez
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Publication number: 20180021140Abstract: A method or apparatus for creating a three-dimensional tissue construct of a desired shape for repair or replacement of a portion of an organism. The method may comprise injecting at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The apparatus may comprise an injector configured to inject at least one biomaterial in a three-dimensional pattern into a first material such that the at least one biomaterial is held in the desired shape of the tissue construct by the first material. The first material may comprise a yield stress material, which may be a material exhibiting Herschel-Bulkley behavior. The tissue construct may have a smallest feature size of ten micrometers or less.Type: ApplicationFiled: February 12, 2016Publication date: January 25, 2018Applicants: University of Florida Research Foundation, Inc., Georgia Tech Research CorporationInventors: Thomas Ettor Angelini, Wallace Gregory Sawyer, Kyle Gene Rowe, Tapomoy Bhattacharjee, Alberto Fernandez-Nieves, Ya-Wen Chang, Samantha M. Marquez
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Publication number: 20170361534Abstract: A method or apparatus for three-dimensionally printing. The method may comprise causing a phase change in a region of the first material by applying focused energy to the region using a focused energy source, and displacing the first material with a second material. The apparatus may comprise a container configured to hold a first material, a focused energy source configured to cause a phase change in a region of the first material by applying focused energy to the region, and an injector configured to displace the first material with a second material. The first material may comprise a yield stress material, which is a material exhibiting Herschel-Bulkley behavior. The yield stress material may comprise a soft granular gel. The second material may comprise one or more cells.Type: ApplicationFiled: December 4, 2015Publication date: December 21, 2017Applicants: University of Florida Research Foundation, Inc., Georigia Tech Research CorporationInventors: Alberto Fernandez-Nieves, Thomas Ettor Angelini, Ya-Wen Chang, Samantha M. Marquez
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Publication number: 20150290362Abstract: Composite constructs of polymer matrices and polymeric microgels, and methods of making and using thereof, are described. The addition of the microgels to polymeric matrices retains the overall mechanical properties of the matrices and enables cell spreading, invasion and vascularization. Using fibrin as a model system, composite fibrin constructs with microgels are described, in which microgels form unique interconnected pockets within the fibrin matrix. The microgel assembly is driven by the polymerization dynamics of fibrin, and the architecture of these interconnected pockets can be tuned. The composite constructs support cell spreading, migration and infiltration more efficiently than do control matrices. The composite constructs can be used attract cells and/or to deliver therapeutic, diagnostic, nutraceutical, prophylactic and cosmetic agents to a desired site.Type: ApplicationFiled: April 10, 2015Publication date: October 15, 2015Inventors: Alison Douglas, Thomas Barker, Louis Andrew Lyons, Alberto Fernandez-Nieves
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Patent number: 7776927Abstract: The present invention generally relates to emulsions such as multiple emulsions, and to methods and apparatuses for making emulsions, and techniques for using the same. A multiple emulsion generally describes larger droplets that contain one or more smaller droplets therein which, in some cases, can contain even smaller droplets therein, etc. Emulsions, including multiple emulsions can be formed in certain embodiments with generally precise repeatability, and can be tailored to include any number of inner droplets, in any desired nesting arrangement, within a single outer droplet. In addition, in some aspects of the invention, one or more droplets may be controllably released from a surrounding droplet.Type: GrantFiled: March 28, 2008Date of Patent: August 17, 2010Assignee: President and Fellows of Harvard CollegeInventors: Liang-Yin Chu, Ho Cheung Shum, Alberto Fernandez-Nieves, Andrew S. Utada, Enric Santanach Carreras, David A. Weitz
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Publication number: 20090012187Abstract: The present invention generally relates to emulsions such as multiple emulsions, and to methods and apparatuses for making emulsions, and techniques for using the same. A multiple emulsion generally describes larger droplets that contain one or more smaller droplets therein which, in some cases, can contain even smaller droplets therein, etc. Emulsions, including multiple emulsions can be formed in certain embodiments with generally precise repeatability, and can be tailored to include any number of inner droplets, in any desired nesting arrangement, within a single outer droplet. In addition, in some aspects of the invention, one or more droplets may be controllably released from a surrounding droplet.Type: ApplicationFiled: March 28, 2008Publication date: January 8, 2009Applicant: PRESIDENT AND FELLOWS OF HARVARD COLLEGEInventors: Liang-Yin Chu, Ho Cheung Shum, Alberto Fernandez-Nieves, Andrew S. Utada, Enric Santanach Carreras, David A. Weitz