Patents by Inventor Alberto Luis Epstein

Alberto Luis Epstein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Inducible highly productive rAAV packaging cell-lines
    Publication number: 20040014031
    Abstract: The present invention relates to an isolated nucleic acid sequence comprising a first DNA sequence comprising a cis-acting replication element (CARE) from an Adeno-Associated Virus (AAV), and a second DNA sequence operably linked to said CARE, wherein amplification of said isolated nucleic acid sequence occurs when said isolated nucleic acid sequence is integrated in the genome of a cell and said cell is contacted with a CARE-dependent replication unducer (CARE-DRI). It also relates to amplification methods using a CARE-dependent replication inducer (CARE-DRI) and packaging cell-lines wherein replication of the integrated rep and cap genes is inducible by a CARE-DRI.
    Type: Application
    Filed: August 7, 2002
    Publication date: January 22, 2004
    Inventors: Anna Salvetti, Gilliane Chadeuf, Jacques Tessier, Philippe Moullier, Michael R. Linden, Peter Ward, Alberto Luis Epstein