Abstract: A novel process is described for the preparation of the active principle pantoprazole based on the use of novel intermediate compounds of general formula (I) where X is an atom of halogen and n=0 or 1, so that when n=1, the intermediate compounds are methoxylated, and when n=0 said intermediate compounds are first oxidized to n=1 and thereafter are methoxylated. Also described are the novel intermediates, as well as the process for the preparation thereof.

Abstract: A novel process is described for the preparation of the active principle pantoprazole based on the use of novel intermediate compounds of general formula (I) where X is an atom of halogen and n=0 or 1, so that when n=1, the intermediate compounds are methoxylated, and when n=0 said intermediate compounds are first oxidized to n=1 and thereafter are methoxylated. Also described are the novel intermediates, as well as the process for the preparation thereof.

Abstract: There is disclosed a process for the preparation of compounds having ACE inhibitory action of the formula ##STR1## wherein R has the meanings as in claim 1, wherein the stereospecific amino acid N-?1-(S)-ethoxycarbonyl-3-phenylpropyl!-L-alanine is carboxylically activated with a thionyl chloride derivative wherein at least one chlorine atom is replaced by the residue of a heterocyclic ambident compound such as imidazole, benzimidazole, 2-methylimidazole or triazole, especially chlorothionylimidazole or thionyldiimidazole, in the presence of an organic solvent to the intermediate novel compound A or to the intermediate novel compound B and the obtained intermediate compound is reacted with an amino acid, preferably in the monosilylated form, most preferably in the disilylated form. Disclosed are also novel compounds useful as starting materials or intermediates in the present process.

Abstract: The process comprises a first step of O-acylation and subsequent acyloxylation of the 2-position methyl group of 2,3,5-trimethyl-4-methoxypyridine N-oxide, to obtain a compound which is subjected to a final halogenation step, in which the 2-position substituent is converted into halomethyl with a halogenating agent.

Abstract: The preparation comprises a nucleus formed by a mixture of omeprazol or an alkali salt of omeprazol with a first basic compound; the nucleus has two coatings, the first of which is formed by one or more layers formed by a basic water soluble excipient and by a second basic compound, while the second coating is formed by an enteric coating.

Abstract: An improved process is disclosed for the preparation of 7-amino and 7-substituted amino-desacetoxycephalosporins in which the corresponding 6-substituted amino penicillin sulphoxide is heated in the presence of an acidic substance which causes expansion of the penam ring in the reactant to the .DELTA..sup.3 cephem ring in the product in the presence of a silicon containing compound. The process comprises adding sulphamide or a silylsulphamide or a silylsulphamoyl to the reaction or utilizing a silylsulphamide or silylsulphamoyl as the silicon containing compound.

Abstract: Amino-beta-lactamic acid salts, having the formula: ##STR1## wherein: (X-Y) may form a system having from 1 to 3 carbon atoms, with or without double bond, (a) closed, in which: X is an atom selected from among carbon, oxygen, nitrogen and sulphur; Y is methylene; Z is a carboxy, sulphonic or phosphonic group (b) open, which may comprise a double bond, in which: X is an atom of hydrogen or a methyl, hydroxymethyl or thiol group, Y is an acid radical chosen from the group formed by sulphonic, phosphonic and sulphoamidic acid; Z is missing. R is an atom or hydrogen, or a methoxyl or ethoxyl group. R.sub.1 is, when present, methyl, acetoxymethyl, acylthiomethyl, such as acetyl and benzoyl derivatives, methoxy, chlorine, carbamoyloxymethyl, azido, azidomethyl (alpha, beta)-thioethylamine or a thiomethyl-heterocyclic derivative of the thiazole, thiadiazole, triazole, tetrazole, oxazole, oxadiazole, pyrimidine and imidazole nuclei. R.sub.2 is an atom of hydrogen or a methyl, ethyl, benzyl or phenyl group.

Abstract: A 3-substituted 7-aminocephalosporanic acid of formula: ##STR1## where R.sub.1 is hydrogen, methyl of methoxy, Y is nitrogen, oxygen sulphur or a sulphoxide group, R.sub.2 is a group selected from among azide or from a radical having the formula R.sub.3 --S-- where R.sub.3 may be, among others, alkyl, aliphatic acyl, methyl and chlorine or methoxy substituted aromatic acyl, is prepared. A compound of formula ##STR2## (X being chlorine, carbamoyloxy or acetoxy) is added to a medium constituted by water, a compound which may be nitric acid or a compound of formula R.sub.3 --SH and a tertiary organic base. With a reaction isoelectric pH regulator, the mixture takes on a specific process pH analytical profile, the compounds of said mixture being reacted together at particular temperatures and with a specific process time.

Abstract: A process for the preparation of solutions of 7-aminocephalosporanic acids wherein there is obtained a salt of the general formula III: ##STR1## where R.sub.1 may be a group selected from among hydrogen, methyl, or a low molecular weight alkoxy, R.sub.2 is a group selected from among methyl, methoxy, azido, chlorine, carbamoylmethyl, acetoxy, thiomethyl, phenylthiomethyl and others, x means from 3 to 5 carbon atoms and y means from 2 to 4 carbon atoms is disclosed. The process is based on the reaction of a compound of formula I ##STR2## with a bicyclic amidine.