Abstract: The present invention is a power line cut-out switch used in power transmission system comprising a base member having a vertical extension member perpendicularly attached thereon that secures a mechanical jumper used when transferring power lines from one electrical post to another. The vertical member can include a mushroom top member to further secure the mechanical jumper. The mechanical jumper is mounted to the vertical extension member to provide a stable and secure point of engagement when transferring power lines. This avoids electrocution to workers by no longer having to connect the mechanical jumper to flimsy solid jumpers and helps provide more uninterrupted power supply to consumers when installing new posts or shifting old posts to a new location.

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract: The present disclosure provides methods of treating, ameliorating, or preventing immune disorders, allergic disorders, or inflammatory disorders, or combinations thereof, or providing hepatoprotection in subject. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a ?-hydroxy-?-aminophosphonate or ?-amino-?-aminophosphonate.

Abstract: A system for analyzing hardware of a turbine controller includes a user interface to receive a user input. The system further includes a turbine controller analysis assembly configured to generate a representation of information corresponding to devices and signals of the turbine controller based on receiving a first query from the user interface and a turbine controller selection from the user interface. The turbine controller analysis assembly is further configured to generate a representation of a bill of materials to modify the turbine controller with a first turbine controller modification module based on receiving from the user interface a first data module selection signal corresponding to the first turbine controller modification module.

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract: This invention relates to a differential release formulation containing an angiotensin-II receptor antagonist, a calcium channel blocker and a diuretic, wherein the said pharmaceutical composition allows the sequential administration of the active principles in a single dose based on the treatment needs.

Abstract: The present invention relates to the field of human and veterinary medicine. The invention solves the problem associated with the lack of an agent for improving the immune response in immunosuppressed individuals, or with autoimmunity problems as well as infections; reducing the effects of the stress, combating tissue fibrosis; the need for anti-inflammatory agents; treatments for acute and chronic hepatitis, treatments against malignant processes and metastasis, as well as thrombocytopenia, both in humans and animals. The present invention comprises a molecular complex formed by a metallic ion and a peptide as novel compound, which is denominated as an immunomodulator metallopeptide hereafter abbreviated as IMMP. Claims also include the process for obtaining the complex, the use of the metallopeptide for producing a therapeutic or nutraceutic agent, and the use of that agent in humans and animals.

Abstract: A system for analyzing hardware of a turbine controller includes a user interface to receive a user input. The system further includes a turbine controller analysis assembly configured to generate a representation of information corresponding to devices and signals of the turbine controller based on receiving a first query from the user interface and a turbine controller selection from the user interface. The turbine controller analysis assembly is further configured to generate a representation of a bill of materials to modify the turbine controller with a first turbine controller modification module based on receiving from the user interface a first data module selection signal corresponding to the first turbine controller modification module.

Abstract: The present invention relates to heterocyclic substituted quinoline derivatives as allosteric inhibitors of the glycogen synthase kinase-3 (GSK-3) enzyme. Therefore, these compounds are useful for the manufacturing of a medicament designed for the treatment and/or prevention of diseases wherein GSK-3 is involved, such as neurodegenerative diseases, inflammatory diseases, cancer, diabetes, and to promote various regenerative processes.

Abstract: The present invention relates to polyene macrolide derivatives according to the formula: wherein M is a macrocyclic lactone ring; N is a polyene sugar, substituted or unsubstituted; X is independently selected from O, S, N or NH; R is independently selected from an alkyl, cycloalkyl, heterocycloalkyl aryl, heteroaryl, arylalkyl, and heteroaryalkyl group; and i is an integer from 1 to 3, with the condition that it has a negative charge or the zwitterions character is restored; or a pharmaceutically acceptable salt thereof useful as antibiotics.

Abstract: The present disclosure provides methods of treating, ameliorating, or preventing immune disorders, allergic disorders, or inflammatory disorders, or combinations thereof, or providing hepatoprotection in subject. In one aspect, the method comprises administering to a subject a therapeutically effective amount of a ?-hydroxy-?-aminophosphonate or ?-amino-?-aminophosphonate.

Abstract: A system includes an interface configured to receive one or more images from an inspection of a component of a mechanical system. Each of the one or more images includes corresponding annotations that at least define one or more dimensions of the component or damages observed in the component. The system also includes a processor configured to construct a degradation model for the component based, at least in part, on the one or more images and their corresponding annotations received by the interface. The processor is further configured to determine one or more maintenance recommendations for the component based, at least in part, on the degradation model constructed for the component.

Abstract: A flow pattern enhancer system mainly for gas-producing oil wells with liquid load problems, comprising mechanical elements that atomize the liquids accumulated at the bottom of the well facilitating their transport to the surface, by decreasing frictional pressure drops and weight of the hydrostatic column.

Abstract: A mobile platform such as, but not limited to, a skateboard or roller skate type of structure capable of movably transporting an individual over a supporting surface. A wheel assembly connected to the platform includes at least one but more practically a plurality of wheels each having a spherical configuration extending outwardly from opposite surfaces of the platform. A mounting assembly and each of a plurality of different embodiments of a bearing assembly are structured to facilitate a substantially universal, rotational movement of said wheel(s) relative to said platform. The different embodiments of the bearing assembly facilitate either a free or unrestricted universal rotational movement of the one wheel relative to the platform or alternatively a universal, rotational movement thereof concurrently about more defined rotational axes.

Abstract: A mobile platform such as, but not limited to, a skateboard or roller skate type of structure capable of movably transporting an individual over a supporting surface. A wheel assembly connected to the platform includes at least one but more practically a plurality of wheels each having a spherical configuration extending outwardly from opposite surfaces of the platform. A mounting assembly and each of a plurality of different embodiments of a bearing assembly are structured to facilitate a substantially universal, rotational movement of said wheel(s) relative to said platform. The different embodiments of the bearing assembly facilitate either a free or unrestricted universal rotational movement of the one wheel relative to the platform or alternatively a universal, rotational movement thereof concurrently about more defined rotational axes.

Abstract: A mobile platform such as, but not limited to, a skateboard type of structure capable of movably transporting an individual over a supporting surface. A wheel assembly connected to the platform includes at least one but more practically a plurality of wheels having a spherical configuration extending outwardly from opposite surfaces of the platform into engagement with the supporting surface so as to define at least two operative positions of the platform. A mounting assembly and each of a plurality of different embodiments of a bearing assembly are structured to facilitate a substantially universal, rotational movement of said wheel(s) relative to said platform. The different embodiments of the bearing assembly facilitate either a free or unrestricted universal rotational movement of the one wheel relative to the platform or alternatively a universal, rotational movement thereof concurrently about more defined rotational axes.

Abstract: A method of generating power vectors to calculate power dissipation for a circuit is provided. The circuit includes both combinational logic and sequential logic circuits. The method includes removing all sequential logic circuits from the circuit. Boolean equations that describe the logical operation of the combinational logic of the circuit cells are generated. Power vectors are generated from the Boolean equations corresponding to internal and output transitions which dissipate power in the circuit. Redundant power vectors are then eliminated. The power vectors are then analyzed for "consistent" behavior with the sequential logic circuits. Operation of sequential logic circuits follow an ordered or defined sequence of events. Power vectors that are "inconsistent" with the operation of the sequential logic circuits are eliminated. The remaining power vectors are used to simulate the power dissipation of the circuit.