Abstract: The present invention relates to a radiopharmaceutical compound or composition for Positron Emission Tomography (PET) imaging of interleukin-2 (IL2) receptor positive cells, in particular, 68Ga-radiolabelled interleukin-2 such as a desalanyl-1, serine-125 human interleukin-2 (dsIL2) radiolabelled with a short-lived PET radioisotope (or radionuclide) gallium-68 (68Ga) by using tris-(hydroxypyridinone-maleimide) (THP-mal) as a chelator. The invention concerns also a kit comprising dsIL2 linked to THP-mal which can be added with 68Ga in order to obtain the above mentioned radiopharmaceutical, at room temperature, suitable for PET imaging, a process for the preparation of the radiopharmaceutical and its use in medical and diagnostic field.

Abstract: A disposable device (1) for introduction, treatment and sampling of biological material from at last one of the separation phases under sterility and constant pressure conditions includes a sealed sterile test tube (2), having a first opening (4), or sampling opening, a second opening (7) or inlet opening, and a third opening (8), the first opening (4) providing the passage of a needle (5), coupling between the needle (5) and the first opening (4) being a sealing coupling by an elastic element (6) allowing translation in a substantially vertical direction and inclination of the needle (5). The second opening is sealed by a membrane (7) made of a material allowing the piercing by a syringe needle and closing back after the removal of the needle, the third opening (8) providing a sealing valve (8) balancing the pressure inside the test tube and environmental pressure.