Patents by Inventor Alberto Varalli

Alberto Varalli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of gemcitabine hydrochloride
    Patent number: 8299239
    Abstract: Disclosed is the preparation of 2-deoxy-D-erythro-2,2-difluoro-ribofuranose-3,5-dibenzoate, a known intermediate for the preparation of Gemcitabine, by means of a reduction process; further disclosed is the purification of Gemcitabine by chromatography and the purification of Gemcitabine hydrochloride by crystallization techniques from ternary solvent mixtures. The main advantage of the invention is providing Gemcitabine hydrochloride with purity in conformity with the Pharmacopoeia requirements, as well as a process particularly convenient from the industrial point of view.
    Type: Grant
    Filed: October 21, 2009
    Date of Patent: October 30, 2012
    Assignee: Prime European Therapeucials S.p.A.
    Inventors: Alberto Varalli, Paolo Anesa, Maria Argese, Giuseppe Guazzi
  • PROCESS FOR THE PREPARATION OF GEMCITABINE HYDROCHLORIDE
    Publication number: 20100105887
    Abstract: Disclosed is the preparation of 2-deoxy-D-erythro-2,2-difluoro-ribofuranose-3,5-dibenzoate: a known intermediate for the preparation of Gemcitabine, by means of a reduction process; further disclosed is the purification of Gemcitabine by chromatography and the purification of Gemcitabine hydrochloride by crystallization techniques from ternary solvent mixtures. The main advantage of the invention is providing Gemcitabine hydrochloride with purity in conformity with the Pharmacopoeia requirements, as well as a process particularly convenient from the industrial point of view.
    Type: Application
    Filed: October 21, 2009
    Publication date: April 29, 2010
    Applicant: PRIME EUROPEAN THERAPEUTICALS S.P.A.
    Inventors: Alberto Varalli, Paolo Anesa, Maria Argese, Giuseppe Guazzi