Abstract: Described herein are novel PRMT5 inhibitors of Formula I and pharmaceutically acceptable salts thereof, as well as the pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting PRMT5 activity and may have use in treating proliferative, metabolic and blood disorders.

Abstract: An item of sports equipment includes a guy line to which is applied a mechanical tension and which ensures the stability or the rigidity of the item of sports equipment. The sports equipment includes a measuring apparatus which is fastened to the guy line such that the guy line tension is applied to it, the measuring apparatus including a sensor adapted to deliver an electrical signal corresponding to representational information on the guy line tension. The measuring apparatus is fastened to the guy line all the time, making it possible to obtain representational information on the guy line tension at any instant.

Abstract: A computer-implemented method for characterizing a circuit is presented. The method includes receiving, by the computer, data representative of the circuit and at least one defect of the circuit. The method further includes simulating, using the computer, the circuit to obtain a first timing characteristic, and simulating, using the computer, the circuit with the at least one defect to obtain a second timing characteristic. The method further includes identifying, using the computer, an association between at least one test vector and the at least one defect in accordance with the first timing characteristic, the second timing characteristic, and a multitude of strobes applied during a first time interval associated with the at least one test vector, when the computer is invoked to characterize the circuit.

Abstract: An item of sports equipment includes a guy line to which is applied a mechanical tension and which ensures the stability or the rigidity of the item of sports equipment. The sports equipment includes a measuring apparatus which is fastened to the guy line such that the guy line tension is applied to it, the measuring apparatus including a sensor adapted to deliver an electrical signal corresponding to representational information on the guy line tension. The measuring apparatus is fastened to the guy line all the time, making it possible to obtain representational information on the guy line tension at any instant.

Abstract: A computer-implemented method for characterizing a circuit is presented. The method includes receiving, by the computer, data representative of the circuit and at least one defect of the circuit. The method further includes simulating, using the computer, the circuit to obtain a first timing characteristic, and simulating, using the computer, the circuit with the at least one defect to obtain a second timing characteristic. The method further includes identifying, using the computer, an association between at least one test vector and the at least one defect in accordance with the first timing characteristic, the second timing characteristic, and a multitude of strobes applied during a first time interval associated with the at least one test vector, when the computer is invoked to characterize the circuit.

Abstract: A novel emulsion polymerization process for the production of fluoroelastomers is disclosed wherein a partially fluorinated anionic surfactant of the formula F—(CF2CF2)n—CH2CH2SO3M, where n is an integer from 2 to 9, or mixtures thereof, and M is a cation having a valence of 1, is used as the dispersing agent.

Abstract: A virtual tape system and method for mapping variable sized data blocks from a host to a fixed sized data block structure of a direct access storage device (DASD) utilizes a buffer between the cache and the host. The control logic operates to access the storage device by transferring data between the cache and the buffer in fixed chunk sizes, and in parallel, transferring data between the host and the buffer in data-chained blocks.

Abstract: Fluoroelastomers having copolymerized units of vinylidene fluoride major monomer, at least one other fluorinated major monomer, and at least one cure site monomer are prepared in an aqueous suspension polymerization process using an initiator consisting essentially of a solution of an oil soluble peroxide in a water-soluble hydrocarbon solvent.

Abstract: Fluoroelastomers having copolymerized units of vinylidene fluoride major monomer, at least one other fluorinated major monomer, and at least one cure site monomer are prepared in an aqueous suspension polymerization process using an initiator consisting essentially of a solution of an oil soluble peroxide in a water-soluble hydrocarbon solvent.

Abstract: A hydraulic transmission control circuit for modulating the controls of a loader includes an accumulator connected to the reverse speed clutch. The accumulator, which has a free sliding piston, has one end communicating with the reverse speed clutch, while the other end of the accumulator has an inlet communicating with the discharge port of a torque converter for charging the accumulator and an outlet communicating with a fluid reservoir through a check valve. A directional control valve may be utilized to selectively connect the accumulator with the reverse speed clutch or a forward speed clutch for respective loader or bulldozer applications.

Abstract: Alkyl lactone esters or sulfidic esters are prepared by reacting an alkenylsuccinic anhydride with an alcohol or thiol in the presence of an acid-acting catalyst. The esters are useful as dispersants or detergents in aqueous or hydrocarbon systems or they may be further reacted with amines to produce other useful additives for such systems. Esters of monohydroxy alcohols or monothiols or polyhydroxy alcohols or polythiols may be prepared and used in this invention.