Patents by Inventor Albertus H. M. T. Van Heertum

Albertus H. M. T. Van Heertum has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (6-fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-(2, 9-disubstituted-4H-pyrido[1,2-a]pyrimidin-4-one) derivatives
    Patent number: 5482943
    Abstract: Novel 2,9-disubstituted-4H-pyrido[1,2-a]pyrimidin-4-ones having the formula ##STR1## the pharmaceutically acceptable acid addition salts thereof, and the stereochemically isomeric forms thereof, whereinAlk represents C.sub.1-4 alkanediyl,D is a bicyclic heterocycle of formula ##STR2## wherein R.sup.1 represents C.sub.1-4 alkyl, hydroxyC.sub.1-4 alkyl, carboxaldehyde, carboxyl, C.sub.1-10 alkylcarbonyloxyC.sub.1-4 alkyl; each R.sup.2 represents hydrogen or C.sub.1-4 alkyl; R.sup.3 represents C.sub.1-4 alkyl, hydroxyC.sub.1-4 alkyl or methyl substituted with phenyl, 5-methyl-2-furanyl or 3-pyridinyl; and R.sup.4 represents C.sub.1-3 alkyl, phenyl, 5-methyl-2-furanyl or 3-pyridinyl.
    Type: Grant
    Filed: March 28, 1991
    Date of Patent: January 9, 1996
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ludo E. J. Kennis, Jan Vandenberk, Albertus H. M. T. Van Heertum
  • Antihypertensive 3-piperidinyl-indazole derivatives
    Patent number: 5321028
    Abstract: 3-Piperidinyl-indazole derivatives and their pharmaceutically acceptable acid addition salts being useful antagonists of neurotransmitters; pharmaceutical compositions containing the same and a method of treating warm-blooded animals suffering from diseases associated with the release of said neutrotransmitters.
    Type: Grant
    Filed: December 3, 1992
    Date of Patent: June 14, 1994
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Vandenberk, Ludo E. J. Kennis, Albertus H. M. T. Van Heertum
  • Antihypertensive 3-piperidinyl-indazole derivatives
    Patent number: 5196425
    Abstract: 3-Piperidinyl-indazole derivatives and their pharmaceutically acceptable acid addition salts being useful antagonists of neurotransmitters; pharmaceutical compositions containing the same and a method of treating warm-blooded animals suffering from diseases associated with the release of said neutrotransmitters.
    Type: Grant
    Filed: July 17, 1989
    Date of Patent: March 23, 1993
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Jan Vandenberk, Ludo E. J. Kennis, Albertus H. M. T. Van Heertum