Patents by Inventor Albin Hermetter
Albin Hermetter has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110224096Abstract: An assay library comprising 14 fluorescently labeled phosphonate esters which act as serine hydrolase inhibitors is provided as an analytical tool enabling activity based identification of serine hydrolases and characterization of enzyme preparations, protein mixtures and complex proteome samples.Type: ApplicationFiled: March 1, 2011Publication date: September 15, 2011Applicant: TECHNISCHE UNIVERSITAT GRAZInventors: Albin Hermetter, Hannes Schmidinger, Gernot Riesenhuber, Heidrun Susani-Etzerodt, Ruth Birner-Grünberger
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Patent number: 7906674Abstract: The invention relates to oxidized phospholipids having one of the general formulas (I) or (II) wherein A?O, C, NH, or S; B?O, C, NH, or S; and R2 is selected from the group consisting of —CO—(CH2)n—CH3; —CO—(CH2)n—CHO; and —CO—(CH2)n—COOH, with n=3-7, with the proviso that in general formula (I), R1 is selected from the group consisting of —CH2—(CH2)n—X; and —CO—(CH2)n—X with n=5-11, wherein X is a fluorophore; and in general formula (II), R1 is selected from the group consisting of —CH?CH—(CH2)n—CH3 with n=9-15; —(CH2)n—CH3 with n=11-17; and —CO—(CH2)n—CH3 with n=10—16; and R3 is selected from the group consisting of —CO—(CH2)n—X; and —SO2—(CH2)n—X, with n=0-5, wherein X is a fluorophore.Type: GrantFiled: July 26, 2006Date of Patent: March 15, 2011Inventors: Albin Hermetter, Michael Trenker
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Patent number: 7772402Abstract: The invention relates to compounds having general formula I in which X represents an optically detectable moiety, n is an integer with 1?n?20, R1 is an unbranched or branched alkyl group having 1 to 20 carbon atoms, and R2 is hydrogen or —CH2—O—R3 group, wherein R3 has the same meaning as R1. These compounds are useful as inhibitors of lipolytic enzymes and can be used as tools for analysis as well as discrimination of lipolytic enzymes in biological samples.Type: GrantFiled: June 23, 2009Date of Patent: August 10, 2010Assignee: Austria Wirtschaftsservice Gesellschaft Mit Beschrankter HaftungInventors: Albin Hermetter, Olga Oskolkova
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Publication number: 20090258422Abstract: The invention relates to compounds having general formula I in which X represents an optically detectable moiety, n is an integer with 1?n?20, R1 is an unbranched or branched alkyl group having 1 to 20 carbon atoms, and R2 is hydrogen or —CH2—O—R3 group, wherein R3 has the same meaning as R1. These compounds are useful as inhibitors of lipolytic enzymes and can be used as tools for analysis as well as discrimination of lipolytic enzymes in biological samples.Type: ApplicationFiled: June 23, 2009Publication date: October 15, 2009Applicant: AUSTRIA WIRTSCHAFTSSERVICE GESELLSCHAFT MIT BESCHRANKTER HAFTUNGInventors: Albin HERMETTER, Olga Oskolkova
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Patent number: 7601845Abstract: The invention relates to compounds having general formula I in which X represents an optically detectable moiety, n is an integer with 1?n?20, R1 is an unbranched or branched alkyl group having 1 to 20 carbon atoms, and R2 is hydrogen or —CH2—O—R3 group, wherein R3 has the same meaning as R1. These compounds are useful as inhibitors of lipolytic enzymes and can be used as tools for analysis as well as discrimination of lipolytic enzymes in biological samples.Type: GrantFiled: September 16, 2005Date of Patent: October 13, 2009Assignee: Austria Wirtschaftsservice Gesellschaft mit beschrankter HaftungInventors: Albin Hermetter, Olga Oskolkova
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Publication number: 20090130648Abstract: The invention relates to oxidized phospholipids having one of the general formulas (I) or (II) wherein A=O, C, NH, or S; B?O, C, NH, or S; and R2 is selected from the group consisting of —CO—(CH2)n—CH3; —CO—(CH2)b—CHO; and —CO—(CH2)n—COOH, with n=3-7, with the proviso that in general formula (I), R1 is selected from the group consisting of —CH2—(CH2)n—X; a —CO—(CH2)n—X with n=5-11, wherein X is a fluorophore; and in general formula (II), R1 is selected from the group consisting of —CH?CH—(CH2)n—CH3 with n=9-15; —(CH2)n—CH3 with n=11-17; and —CO—(CH2)n—CH3 with n=10-16; and R3 is selected from the group consisting of —CO—(CH2)n—X; and —SO2—(CH2)n—X, with n=0-5, wherein X is a fluorophore.Type: ApplicationFiled: July 26, 2006Publication date: May 21, 2009Applicants: TECHNISCHE UNIVERSITÄT GRAZ, FORSCHUNGSHOLDING TU GRAZ GMBHInventors: Albin Hermetter, Michael Trenker
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Publication number: 20080108508Abstract: An assay library comprising 14 fluorescently labeled phosphonate esters which act as serine hydrolase inhibitors is provided as an analytical tool enabling activity based identification of serine hydrolases and characterization of enzyme preparations, protein mixtures and complex proteome samples.Type: ApplicationFiled: June 6, 2005Publication date: May 8, 2008Applicant: TECHNISCHE UNIVERSITÄT GRAZInventors: Albin Hermetter, Hannes Schmidinger, Gernot Riesenhuber, Heidrun Susani-Etzerodt, Ruth Birner-Grunberger
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Publication number: 20060134715Abstract: The invention relates to compounds having general formula I in which X represents an optically detectable moiety, n is an integer with 1?n?20, R1 is an unbranched or branched alkyl group having 1 to 20 carbon atoms, and R2 is hydrogen or —CH2—O—R3 group, wherein R3 has the same meaning as R1. These compounds are useful as inhibitors of lipolytic enzymes and can be used as tools for analysis as well as discrimination of lipolytic enzymes in biological samples.Type: ApplicationFiled: September 16, 2005Publication date: June 22, 2006Applicant: Austria Wirtschaftsservice Gesellschaft Mit Beschrankter HaftungInventors: Albin Hermetter, Olga Oskolkova
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Patent number: 5972982Abstract: Heteroaryl-substituted deoxy glycerols represented by the general Formulas Ia, Ib and Ic: ##STR1## wherein: X is oxygen (--O--) or sulfur (--S--); R is substituted or unsubstituted straight or branched chain C.sub.1-30 alkyl or alkenyl, provided that a double bond of the alkenyl does not originate at the carbon atom bound to the X substituent; Het is a 5- to 9-membered heteroaryl mono- or bicyclic ring system having no more than 1 carbonyl carbon in the ring system, with 1 to 4 nitrogen atoms as the sole heteroatoms, one of which nitrogens is bonded to the glycero carbon; and Y is hydroxyl (--OH) or thiol (--SH), pharmaceutical compositions containing the same, and methods of using the compounds, are disclosed. The compounds exhibit antiviral and antibacterial activities.Type: GrantFiled: October 7, 1997Date of Patent: October 26, 1999Assignee: Clarion Pharmaceuticals Inc.Inventors: Haridasan K. Nair, Andrew C. Peterson, Friedrich Paltauf, Albin Hermetter, Rudolf Franzmair
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Patent number: 5707978Abstract: Therapeutically active, heteroaryl-substituted deoxy glycero-phosphoethanolamines are disclosed having the general Formula I: ##STR1## wherein one of X, Y or Z is a fatty ether substituent, one is a heteroaryl ring substituent with 1-4 nitrogens as the only heteroatoms, one of which is bonded to a carbon of the glyceryl backbone, and one is a phosphoethanolamine substituent substituted at the nitrogen, provided that each of X, Y and Z is a different substituent, and the pharmaceutical compositions comprising the therapeutically active compounds and methods of using the therapetically active compounds to treat cancerous tumors, psoriasis and inflammation are also disclosed.Type: GrantFiled: June 7, 1995Date of Patent: January 13, 1998Assignee: Clarion Pharmaceuticals Inc.Inventors: Friedrich Paltauf, Albin Hermetter, Rudolf Franzmair
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Patent number: 5665714Abstract: The present invention relates to novel, therapeutically active fatty alkyl and alkenyl ether glycerophospholipids bearing a 3-(2-imidazolinyl)-2-imidazolinyl or 2-imidazolinyl substituent on the ethanolamine nitrogen, methods of using the compounds and pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing same. The novel, therapeutically active compounds and salts of the invention possess anti-tumor, anti-psoriatic, anti-inflammatory, and anti-asthma activities.Type: GrantFiled: December 3, 1996Date of Patent: September 9, 1997Assignee: Clarion Pharmaceuticals Inc.Inventors: Friedrich Paltauf, Albin Hermetter, Rudolf Franzmair
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Patent number: 5155099Abstract: Compounds of formula I ##STR1## in which R denotes a straight-chain or branched, saturated or unsaturated aliphatic hydrocarbon radical having 6-30 C atoms wich may optionally be substituted by halogen or the radicals OR.sub.1, SR.sub.1 or NR.sub.1 R.sub.2, where R.sub.1 and R.sub.2 in each case denote a hydrogen atom or an alkyl or acyl radical having 1-6 C atoms which have excellent virustatic and cytostatic action.Type: GrantFiled: October 19, 1990Date of Patent: October 13, 1992Assignee: Hafslund Nycomed Pharma AktiengesellschaftInventors: Hans Brachwitz, Reinhild Schonfeld, Peter Langen, Friedrich Paltauf, Albin Hermetter
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Patent number: 4916249Abstract: The invention relates to novel glycero-3(2)phospho-L-serine derivatives of the general formula ##STR1## in which A represents unsubstituted or substituted (C5-C30) alkoxy, or unsubstituted or substituted (C5-C30) alkenoxy, whereby a double bond of the alkenoxy residue does not originate at the C atom bound to oxygen, or halogen, or a group of the general formula--O--(CH.sub.2).sub.n --CF.sub.3 II,wherein n is 0 or an integer 1, 2 or 3, one of the two residues B and C, which is identical to or different from A, has one of the definitions given for A or represents hydrogen, and the respective other residue represents the phosphatidyl-Lserine group of the formula ##STR2## with the proviso that at least one residue A, B or C represents (C5-C30) alkoxy or (C5-C30) alkenoxy; and the pharmaceutically acceptable salts of compounds of general formula I with bases, a process for the preparation thereof, pharmaceutical preparations containing the said compounds, and their use in drugs with cytostatic activity.Type: GrantFiled: July 7, 1989Date of Patent: April 10, 1990Inventors: Hans Brachwitz, Peter Langen, Christine Lehmann, Eckart Matthes, Jurgen Schildt, Iduna Fichtner, Albin Hermetter, Friedrich Paltauf
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Patent number: 4814112Abstract: Single-stage process for preparing mixed-substituted enantiomerically pure 1,2-diacyl-sn-glycero-3-phosphocholines of general formula I ##STR1## in which R.sub.1 and R.sub.2 are different and independently of each other denote a substituted or unsubstituted C.sub.1 to C.sub.24 -alkyl or C.sub.3 to C.sub.24 -alkenyl radical, by reacting 1-0-triphenylmethyl-2-acyl-sn-glycero-3-phosphocholine of the general formula ##STR2## in which T denotes a substituted or unsubstituted triphenylmethyl group and R.sub.2 is as defined above, with a reactive carboxylic acid derivative of the general formulaR.sub.1 --CO--X IIIin which R.sub.Type: GrantFiled: November 10, 1987Date of Patent: March 21, 1989Assignee: CL Pharma AktiengesellschaftInventors: Friedrich Paltauf, Albin Hermetter, Rudolf Franzmair
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Patent number: 4717512Abstract: Preparation of chemically defined pure enantiomeric 1,2-diacyl-sn-glycero-3-phosphocholines and 1,2-diacyl-sn-glycero-3-phosphoethanolamines which are substituted in positions 1 and 2 of the glycerol, by acylation of triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine.Type: GrantFiled: July 29, 1986Date of Patent: January 5, 1988Assignee: Chemie Linz AktiengesellschaftInventors: Friedrich Paltauf, Albin Hermetter
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Derivatives of glycerophosphocholine and glycerophosphoethanolamine, their preparation and their use
Patent number: 4622180Abstract: The invention relates to new triphenylmethyl derivatives of sn-glycero-3-phosphocholine and sn-glycero-3-phosphoethanolamine of the general formula ##STR1## in which T denotes a triphenylmethyl group which is unsubstituted or monosubstituted or polysubstituted by C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy or halogen, and the radicals R.sub.1, R.sub.2 and R.sub.3 either are identical and each represent a methyl group, or are different, in which case two of the radicals R.sub.1, R.sub.2 and R.sub.3 always denote hydrogen, and the third radical represents a triphenylmethyl group which is unsubstituted or monosubstituted or polysubstituted by C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.Type: GrantFiled: May 13, 1985Date of Patent: November 11, 1986Assignee: Chemie Linz AktiengesellschaftInventors: Friedrich Paltauf, Albin Hermetter