Patents by Inventor Albrecht Franke

Albrecht Franke has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 5214047
    Abstract: A tetracyclic quinazoline derivative of the formula I: ##STR1## wherein A is C.sub.2-3 -alkylene or C.sub.2-3 -alkylene which is substituted by one or two C.sub.1-4 -alkyl radicals or A is cyclohexylene; X is phenyl, naphthyl or phenyl or naphthyl which is substituted by halogen, nitro, amino, C.sub.1-4 -alkylamino, sulfonylamino, C.sub.1-4 -acylamino, hydroxyl, C.sub.1-4 -alkoxy, --O--(CH.sub.2).sub.2-4 --NR.sup.1 R.sup.2, C.sub.1-4 -alkyl or C.sub.1-4 -alkylsulfonyl, wherein R.sup.1 and R.sup.2 are each hydrogen or C.sub.1-4 -alkyl; or X is thienyl or thienyl which is substituted by chlorine, fluorine, methyl, ethyl, methoxy, ethoxy, nitro or hydroxyl; and R is hydrogen, halogen, nitro, amino, C.sub.1-4 -alkylamino, sulfonylamino, C.sub.1-4 -acylamino, hydroxyl, C.sub.1-4 -alkoxy, --O--(CH.sub.2).sub.2-4 --NR.sup.3 R.sup.4, C.sub.1-4 -alkyl or C.sub.1-4 -alkylsulfonyl, wherein R.sup.3 and R.sup.4 are each hydrogen or C.sub.1-4 -alkyl, and the pharmaceutically acceptable salts thereof.
    Type: Grant
    Filed: September 12, 1988
    Date of Patent: May 25, 1993
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Ostersehlt, Rainer Schlecker, Beatrice Rendenbach, Gerda von Philipsborn, Albrecht Franke, deceased
  • Patent number: 5118685
    Abstract: Aminopropanol derivatives of the formula: ##STR1## where R.sup.1 and R.sup.2 are identical or different and are each hydrogen, alkyl, cycloalkyl, alkenyl, alkynyl or hydroxyalkyl, each of not more than 6 carbon atoms, alkoxyalkyl, alkylthioalkyl or dialkylaminoalkyl, each of not more than 9 carbon atoms in total, or phenylalkyl or phenoxyalkyl where the alkyl radical is of not more than 6 carbon atoms and the phenyl radical is unsubstituted or substituted by alkyl or alkoxy, each of not more than 3 carbon atoms, or R.sup.1 and R.sup.2, together with the nitrogen atom which links them, form a 5-membered to 7-membered saturated heterocyclic ring which can be substituted by one or two phenyl and/or hydroxyl radicals and can contain an oxygen or nitrogen atom, as a further heteroatom in the ring, and such an additional nitrogen atom can be substituted by alkyl of 1 to 3 carbon atoms or by phenyl, and -- .circle.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: June 2, 1992
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Wolfgang Spiegler, Hardo Siegel, Claus D. Mueller, Gerda von Philipsborn, Dieter Lenke, Josef Gries
  • Patent number: 4945114
    Abstract: Therapeutic agents containing enantiomers of propafenone, the preparation of the said agents and their use for certain groups of patients.
    Type: Grant
    Filed: July 29, 1988
    Date of Patent: July 31, 1990
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, deceased, Rainer Schlecker, Josef Gries, Gerda Von Philipsborn, Liliane Unger
  • Patent number: 4873246
    Abstract: Novel 6-(acylaminaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.The compounds have thrombocyte aggregation-inhibiting activity.
    Type: Grant
    Filed: October 8, 1986
    Date of Patent: October 10, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Philip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans D. Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4820821
    Abstract: Novel 1-phenyl-4(1H)-pyridazinone-imines of the formula (I) ##STR1## which are substituted at the imine nitrogen, and their addition salts with a physiologically tolerated acid, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs, in particular as antidepressants, antiparkinson drugs and antihypotonic agents.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: April 11, 1989
    Assignee: BASF Aktiengesellschaft
    Inventors: Rudolf Kropp, Marco Thyes, Rainer Schlecker, Albrecht Franke, Franz Reicheneder, Dora I. Reicheneder, August Amann, Hans-Juergen Teschendorf, Rolf Kretzschmar, Martin Traut, Josef Gries
  • Patent number: 4670435
    Abstract: 10,11-Dihydro-5H-dibenzo[a,d]cycloheptadiene derivatives of the formula I ##STR1## where R.sup.1 and R.sup.2 have the meanings stated in the description, and their preparation are described. The novel substances are useful for the treatment of disorders.
    Type: Grant
    Filed: December 2, 1985
    Date of Patent: June 2, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, deceased, Claus D. Mueller, Dieter Lenke
  • Patent number: 4636504
    Abstract: Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described and inhibiting thrombocyte aggregation and gastric secretion.The compounds are useful for treating disorders.
    Type: Grant
    Filed: January 17, 1984
    Date of Patent: January 13, 1987
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans Dieter Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke
  • Patent number: 4612320
    Abstract: Compounds of the general formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4 and n have the meanings given in the description, are useful for treating cardiac disorders.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: September 16, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Gries, Claus D. Mueller, Dieter Lenke
  • Patent number: 4571409
    Abstract: Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
    Type: Grant
    Filed: May 13, 1985
    Date of Patent: February 18, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Mueller, Helmut Lietz, Walter-Wielant Wiersdorff, Hans-Guenther Hege, Claus D. Mueller, Josef Gries, Dieter Lenke, Gerda von Philipsborn, Manfred Raschack
  • Patent number: 4563474
    Abstract: Heterocyclically substituted nitriles of the formula I ##STR1## where X is SO.sub.2, CO, S, SO or CH.sub.2, A is an alkylene or alkenylene radical of not more than 6 carbon atoms, B is --CH.dbd.CH-- or S, and R.sup.1 and R.sup.2 are each hydrogen, halogen, C.sub.1 -C.sub.3 -alkyl, C.sub.1 -C.sub.3 -alkoxy, nitro or trifluoromethyl, and their preparation and use.The novel substances are useful for treating disorders.
    Type: Grant
    Filed: November 16, 1983
    Date of Patent: January 7, 1986
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Gerd Steiner, Hans-Peter Hofmann, Claus-Dieter Muller, Hans-Jurgen Teschendorf
  • Patent number: 4544562
    Abstract: 6-Aryl-4,5-dihydro-3(2H)-pyridazinones of the formula ##STR1## where R is hydrogen, R.sup.1 is hydrogen or C.sub.1 -C.sub.3 -alkyl, or R and R.sup.1 together are methylene, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or C.sub.1 -C.sub.6 -alkyl, and A is hydroxyl, C.sub.1 -C.sub.6 -alkoxy, C.sub.2 -C.sub.7 -acyloxy, a C.sub.2 -C.sub.7 -carbamic acid ester group, C.sub.1 -C.sub.6 -alkylsulfonyloxy, C.sub.1 -C.sub.6 -alkylmercapto, carboxyl, C.sub.2 -C.sub.7 -alkoxycarbonyl or nitrile, and their preparation are described. The substances are suitable for treating disorders.
    Type: Grant
    Filed: March 11, 1983
    Date of Patent: October 1, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Josef Gries, Hans D. Lehmann, Dieter Lenke
  • Patent number: 4540697
    Abstract: Novel aminopropanol derivatives of 2-hydroxy-.beta.-phenyl-propiophenones and their physiologically acceptable acid addition compounds, processes for their preparation and therapeutic agents which contain these derivatives and are useful as antiarrhythmic drugs.
    Type: Grant
    Filed: May 23, 1984
    Date of Patent: September 10, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Josef Muller, Helmut Lietz, Walter-Wielant Wiersdorff, Hans-Gunther Hege, Claus D. Muller, Josef Gries, Dieter Lenke, Gerda von Philipsborn, Manfred Raschack
  • Patent number: 4514413
    Abstract: N-substituted imidazole derivatives of the formula I ##STR1## where R.sup.1, R.sup.2 and R.sup.3 are identical or different and are each hydrogen or alkyl with 1 or 3 carbon atoms and Alk is an alkylene chain of 2 to 4 carbon atoms, and their salts with physiologically tolerated acids, processes for their preparation, drugs containing a compound of the formula I or one of its salts, and their use for treating disorders associated with gastric hyperacidity.
    Type: Grant
    Filed: April 7, 1983
    Date of Patent: April 30, 1985
    Assignee: BASF Aktiengesellschaft
    Inventors: Bernd Ostersehlt, Albrecht Franke, Fritz-Frieder Frickel, Marco Thyes, Ludwig Friedrich, Josef Gries, Dieter Lenke
  • Patent number: 4474785
    Abstract: 2-Aryl-3,4-diazabicyclo[4.n.O]alk-2-en-5-ones of the formula I ##STR1## where m and n are identical or different and each is 1, 2 or 3, and R, R.sup.1 and R.sup.2 are identical or different and each is hydrogen or alkyl of 1 to 6 C atoms, said compounds are useful for treating high blood pressure and thrombo-embolic disorders.
    Type: Grant
    Filed: June 4, 1982
    Date of Patent: October 2, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Josef Gries, Hans D. Lehmann, Dieter Lenke
  • Patent number: 4428950
    Abstract: Novel (hetarylphenoxy)-(phenylpiperazinyl)-propanols of the formula ##STR1## where R.sup.1 is hydrogen, amino or alkyl of 1 to 4 carbon atoms, R.sup.2 is hydrogen, halogen, alkyl of 1 to 4 carbon atoms or alkoxy where alkyl is of 1 to 3 carbon atoms, the phenyl ring can be monosubstituted or disubstituted by R.sup.2, and the heterocyclic structure Het. is pyrimidinyl, triazol-1-yl, imidazol-1-yl, pyrazol-3-yl or isoxazol-3-yl, and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and exhibit predominantly hypotensive, sedative, neuroleptic and broncholytic properties.
    Type: Grant
    Filed: January 15, 1982
    Date of Patent: January 31, 1984
    Assignee: BASF Aktiengesellschaft
    Inventors: Albrecht Franke, Gerd Steiner, Peter C. Thieme, Dieter Lenke, Josef Gries, Hans-Juergen Teschendorf
  • Patent number: 4415571
    Abstract: Novel 6-phenyl-4,5-dihydro-3(2H)-pyridazinones which are substituted in the p-position of the phenyl ring by a carbamate or thiocarbamate group, processes for their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in thrombo-embolic disorders, and as anti-hypertensives.
    Type: Grant
    Filed: June 9, 1981
    Date of Patent: November 15, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Marco Thyes, Albrecht Franke, Horst Koenig, Dieter Lenke, Hans D. Lehmann, Josef Gries
  • Patent number: 4388237
    Abstract: 6-Substituted 11-alkylene-morphanthridines, also referred to as 11-alkylene-dibenzo[b,e]-azepines, their pure cis- and trans-isomers, processes for their preparation, and therapeutic agents containing these compounds, which may be used as drugs, in particular neuroleptics, sedatives, hypnotics, analgesics, antidepressants or agents for treating Parkinson's syndrome.
    Type: Grant
    Filed: May 7, 1980
    Date of Patent: June 14, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Gerd Steiner, Albrecht Franke, Dieter Lenke, Hans-Juegen Teschendorf, Wolfgang Worstmann, Horst Kreiskott
  • Patent number: 4353917
    Abstract: Novel aminopropanol derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole and their addition salts with acids, their preparation, pharmaceutical formulations containing these compounds, and their use as drugs in the treatment of coronary heart disease, hypertonia and cardiac arrhythmias.
    Type: Grant
    Filed: October 23, 1980
    Date of Patent: October 12, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Fritz-Frieder Frickel, Peter C. Thieme, Albrecht Franke, Helmut Hagen, Dieter Lenke, Josef Gries
  • Patent number: 4353904
    Abstract: Novel phenylpiperazinylpropanols of 1,3,4-oxadiazolylphenols and their physiologically tolerated addition salts with acids, processes for their preparation, and pharmaceutical formulations which contain these compounds and are useful in the treatment of hypertonia.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: October 12, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter C. Thieme, Albrecht Franke, Dieter Lenke, Hans D. Lehmann, Josef Gries
  • Patent number: RE33476
    Abstract: Novel 6-(acylaminoaryl)-3(2H)-pyridazinones of the formula ##STR1## where R.sup.1, R.sup.2, R.sup.3, R.sup.4, A and B have the meanings given in the description, and their preparation are described.[.and inhibiting thrombocyte aggregation and gastric secretion.]..The compounds are useful for treating disorders .Iadd.and inhibiting thrombocyte aggregation and gastric secretion.Iaddend..
    Type: Grant
    Filed: May 2, 1988
    Date of Patent: December 4, 1990
    Assignee: BASF Akteingesellschaft
    Inventors: Phillip A. Rossy, Marco Thyes, Albrecht Franke, Horst Koenig, Hans D. Lehmann, Josef Gries, Ludwig Friedrich, Dieter Lenke