Patents by Inventor Albrecht PIIPER

Albrecht PIIPER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220184227
    Abstract: The present invention relates in a first aspect to a mutated adeno-associated virus (AAV) capsid protein or fragment thereof having an insert composed of an oligopeptide optionally having further amino acids representing linker sequences flanking both sites of said oligopeptide. These mutated AAV capsid proteins are more efficient in targeting hepatic tissue, hepatocytes, hepatic cells and cell lines or hepatocellular carcinoma (HCC) with partially higher specificity. Further, a mutated AAV particle comprising the mutated AAV capsid protein according to the present invention is provided. In addition, a nucleic acid encoding the mutated AAV capsid protein according to the present invention is identified together with a corresponding nucleic acid vector, in particular, a plasmid. In addition, a host cell containing the nucleic acid vector or the nucleic acid molecule according to the present invention.
    Type: Application
    Filed: March 30, 2020
    Publication date: June 16, 2022
    Inventors: Hildegard BÜNING, Nadja MEUMANN, Maria GONZALEZ-CARMONA, Christian P. STRASSBURG, Annabelle VOGT, Albrecht PIIPER, Joachim SCHWÄBLE, Karin HUBER, Erhard SEIFRIED
  • Publication number: 20180214582
    Abstract: The present invention relates to an imaging diagnostic method, comprising a contrast agent including a contrast enhancer in a magnetic resonance imaging (MRI) assisted diagnosis of carcinoma diseases or carcinomas, in particular of hepatocellular carcinoma (HCC). The contrast agent is preferably a gadolinium compound, preferably Gd-DTPA including iRGD as a contrast enhancer, for the improved imaging of carcinomas, in particular HCC, in MRI. The invention furthermore relates to a method for the risk stratification of patients and subjects using the aforementioned diagnosis.
    Type: Application
    Filed: August 1, 2016
    Publication date: August 2, 2018
    Inventors: Albrecht PIIPER, Christian SCHMITHALS, Thomas J. VOGL