Patents by Inventor Aldina Barral

Aldina Barral has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • polypeptides and methods of use
    Patent number: 10314900
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: January 9, 2018
    Date of Patent: June 11, 2019
    Assignees: The United States of America, as represted by the Secretary, Department of Health and Human Services, Fundaçao Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • LUTZOMYIA LONGIPALPIS POLYPEPTIDES AND METHODS OF USE
    Publication number: 20180147269
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Application
    Filed: January 9, 2018
    Publication date: May 31, 2018
    Applicants: The Government of the United States of America as represented by the Secretary of the Department of, Fundaçao Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • polypeptides and methods of use
    Patent number: 9884100
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishishmaniasis are disclosed.
    Type: Grant
    Filed: June 7, 2016
    Date of Patent: February 6, 2018
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundacão Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • AN IMMUNOTOXIN FOR USE IN THE TREATMENT OF LEISHMANIASIS
    Publication number: 20170369574
    Abstract: An immunotoxin for use in the treatment of leishmaniasis A wherein the immunotoxin comprises a portion which is specifically binding to the cellular surface receptor CD64 as a component A and a cell killing portion as a component B, wherein the cell killing portion alters the function, gene expression, or viability of a cell thereby killing Leishmania-infected macrophages and by this eliminates Leishmania.
    Type: Application
    Filed: January 21, 2016
    Publication date: December 28, 2017
    Applicant: FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.
    Inventors: Stefan Barth, Theophilus Thepen, Manoel Barral-Netto, Aldina Barral, Johan Van Weyenbergh
  • LUTZOMYIA LONGIPALPIS POLYPEPTIDES AND METHODS OF USE
    Publication number: 20160279211
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishishmaniasis are disclosed.
    Type: Application
    Filed: June 7, 2016
    Publication date: September 29, 2016
    Applicants: The Government of the U.S.A. as represented by the Secretary of the Department of Health and Human S, Fundaçao Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • polypeptides and methods of use
    Patent number: 9382302
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: July 5, 2016
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundação Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • LUTZOMYIA LONGIPALPIS POLYPEPTIDES AND METHODS OF USE
    Publication number: 20150315254
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Application
    Filed: July 17, 2015
    Publication date: November 5, 2015
    Applicants: The Government of the United States of America as represented by the Secretary of the Department of, Fundacao Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Barral Netto, Claudia I. Brodskyn, Regis Gomes
  • polypeptides and methods of use
    Patent number: 9120867
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: December 5, 2013
    Date of Patent: September 1, 2015
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Netto, Claudia I. Brodskyn, Regis Gomes
  • LUTZOMYIA LONGIPALPIS POLYPEPTIDES AND METHODS OF USE
    Publication number: 20140093531
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Application
    Filed: December 5, 2013
    Publication date: April 3, 2014
    Applicants: Fundacao Oswaldo Cruz (FIOCRUZ), The Government of the United States of America as represented by the Secretary of the Department of
    Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Netto, Claudia I. Brodskyn, Regis Gomes
  • Lutzomyia longipalpis polypeptides and methods of use
    Patent number: 8628780
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: January 7, 2009
    Date of Patent: January 14, 2014
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services, Fundação Oswaldo Cruz (FIOCRUZ)
    Inventors: Jesus G. Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Netto, Claudia Brodskyn, Regis Gomes
  • LUTZOMYIA LONGIPALPIS POLYPEPTIDES AND METHODS OF USE
    Publication number: 20090117139
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Application
    Filed: January 7, 2009
    Publication date: May 7, 2009
    Inventors: Jesus G. Valenzuela, Jose M.C. Ribeiro, Aldina Barral, Manoel Netto, Claudia Brodskyn, Regis Gomes
  • polypeptides and methods of use
    Patent number: 7485306
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Grant
    Filed: October 29, 2003
    Date of Patent: February 3, 2009
    Assignees: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Jesus G Valenzuela, Jose M. C. Ribeiro, Aldina Barral, Manoel Netto, Claudia Brodskyn, Regis Gomes
  • Lutzomyia longipalpis polypeptides and methods of use
    Publication number: 20060051364
    Abstract: Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed.
    Type: Application
    Filed: October 29, 2003
    Publication date: March 9, 2006
    Inventors: Jesus Valenzuela, Jose Ribeiro, Aldina Barral, Manoel Netto, Claudia Brodskyn, Regis Gomes