Patents by Inventor Aldo A. Algieri

Aldo A. Algieri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chemical intermediates and process
    Patent number: 4927968
    Abstract: The present invention relates to novel intermediates of the formula ##STR1## wherein R.sup.1 is hydrogen or lower alkyl and R is ##STR2## --CH.sub.2 OH or --CH.sub.2 X in which X is a conventional leaving group and Y is lower alkyl and the use thereof in a process for the preparation of certain histamine H.sub.2 -antagonists.
    Type: Grant
    Filed: April 11, 1988
    Date of Patent: May 22, 1990
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Robert F. Farney
  • Substituted 3-cyclobutene-1,2-diones as anti-ulcer agents
    Patent number: 4788184
    Abstract: Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.
    Type: Grant
    Filed: November 13, 1987
    Date of Patent: November 29, 1988
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw
  • 2,5-disubstituted-4(3H)-pyrimidones having histamine H.sub.2 -receptor antagonist activity
    Patent number: 4772704
    Abstract: Histamine H.sub.2 -antagonists of the formula: ##STR1## wherein m is an integer of from zero to 2, inclusive;n is an integer of from 2 to 5 inclusive;Z is sulfur, oxygen or methylene;R.sup.1 is NO.sub.2 or NR.sup.2 R.sup.3 ;R.sup.2 and R.sup.3 each are independently hydrogen or (lower)alkyl, or, when R.sup.2 is hydrogen, R.sup.3 also may be formyl, carboalkoxy, alkanoyl or benzoyl;A is phenyl, furyl, thienyl, pyridyl, thiazolyl, imidazolyl, oxazolyl, oxadiazolyl, thiadiazolyl, triazolyl, isoxazolyl, isothiazolyl, pyrimidinyl, pyrazolyl, pyridazinyl or pyrazinyl; provided that A contains one or two substituents, the first substituent being selected from ##STR2## and the second substituent being selected from (lower)alkyl, hydroxy, trifluoromethyl, halogen, amino, hydroxymethyl and (lower)alkoxy;q is an integer of from 0 to 6, inclusive;R.sup.
    Type: Grant
    Filed: September 21, 1983
    Date of Patent: September 20, 1988
    Assignee: Bristol-Myers Company
    Inventor: Aldo A. Algieri
  • Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.sub.2 -receptor antagonist activity
    Patent number: 4692531
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: September 25, 1986
    Date of Patent: September 8, 1987
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw
  • Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.sub.2 -receptor antagonist activity
    Patent number: 4644006
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: June 22, 1984
    Date of Patent: February 17, 1987
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw
  • 3-cyclobutene-1,2-dione intermediates
    Patent number: 4607105
    Abstract: Certain 1-(substituted amino)-2-(amino or substituted amino)cyclobutene-3,4-diones are potent histamine H.sub.2 -antagonists useful in the treatment of peptic ulcers.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: August 19, 1986
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw
  • Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.sub.2 -receptor antagonist activity
    Patent number: 4600779
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: July 15, 1986
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Ethanediimidamide intermediates
    Patent number: 4595758
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: June 17, 1986
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Ethanediimidamide intermediates
    Patent number: 4588826
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: May 13, 1986
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Substituted amino alkyl pyridyl ethanediimidamides
    Patent number: 4578471
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: December 3, 1984
    Date of Patent: March 25, 1986
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Substituted 1,2-diaminocyclobutene-3,4-diones
    Patent number: 4546188
    Abstract: Certain 1-(substituted amino)-2-(amino or substituted amino)cyclobutene-3,4-diones are potent histamine H.sub.2 -antagonists useful in the treatment of peptic ulcers.
    Type: Grant
    Filed: October 3, 1984
    Date of Patent: October 8, 1985
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw
  • Pyridine derivatives of 1,2-diaminocyclobutene-3,4-diones
    Patent number: 4539316
    Abstract: Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.
    Type: Grant
    Filed: October 1, 1984
    Date of Patent: September 3, 1985
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw
  • Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.sub.2 -receptor antagonist activity
    Patent number: 4528375
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: July 9, 1985
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.sub.2 -receptor antagonist activity
    Patent number: 4528378
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: July 9, 1985
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Substituted 3,4-diamino-1,2,5-thiadiazoles having histamine H.sub.2 -receptor antagonist activity
    Patent number: 4528377
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.1 are as defined herein, and their nontoxic pharmaceutically acceptable salts, hydrates and solvates are novel anti-ulcer agents which are prepared by ring closure of a substituted ethanediimidamide of the formula ##STR2## .
    Type: Grant
    Filed: March 16, 1983
    Date of Patent: July 9, 1985
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Chemical compounds
    Patent number: 4526973
    Abstract: Certain 1-(substituted amino)-2-(amino or substituted amino)cyclobutene-3,4-diones of the general formula ##STR1## are potent histamine H.sub.2 -antagonists useful in the treatment of peptic ulcers. A preferred compound, 1-amino-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dione, is prepared by treating an intermediate, 1-methoxy-2-[3-(3-piperidinomethylphenoxy)propylamino]cyclobutene-3,4-dion e, with ammonia.
    Type: Grant
    Filed: June 9, 1982
    Date of Patent: July 2, 1985
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw
  • Chemical compounds
    Patent number: 4522943
    Abstract: Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.
    Type: Grant
    Filed: April 21, 1982
    Date of Patent: June 11, 1985
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw
  • Intermediates for preparing 3,4-diamino-1,2,5-thiadiazoles
    Patent number: 4517366
    Abstract: Histamine H.sub.2 -receptor antagonists of the formula ##STR1## wherein A, m, Z, n and R.sup.
    Type: Grant
    Filed: April 16, 1984
    Date of Patent: May 14, 1985
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Histamine H.sub.2 -antagonists
    Patent number: 4510309
    Abstract: Histamine H.sub.2 -antagonists of the formula ##STR1## wherein p is 1 or 2; R.sup.1 is hydroxy, amino, substituted amino or a 5- to 9-membered fully saturated nitrogen-containing heterocyclic ring attached via its nitrogen atom; m is an integer of from 0 to 2, n is an integer of from 2 to 4; Z is sulfur, oxygen or methylene; and A is an optionally substituted phenyl, imidazolyl, thiazolyl, isothiazolyl, oxazolyl, isoxazolyl, triazolyl, thiadiazolyl, oxadiazolyl, furyl, thienyl or pyridyl ring; and nontoxic pharmaceutically acceptable salts, hydrates, solvates or N-oxides thereof are novel anti-ulcer agents. Intermediates and processes for their preparation are disclosed.
    Type: Grant
    Filed: May 19, 1983
    Date of Patent: April 9, 1985
    Assignee: Bristol-Myers Company
    Inventors: Ronnie R. Crenshaw, Aldo A. Algieri
  • Substituted 3-cyclobutene-1,2-diones, pharmaceutical compositions thereof and methods of use
    Patent number: 4503051
    Abstract: Compounds of the formula ##STR1## wherein R.sup.12 is a leaving group, Z is S, O or CH.sub.2 and A is a phenyl, furyl, thienyl or pyridyl ring substituted by a ##STR2## moiety, in which R.sup.8 and R.sup.9 are various substituents or, when taken together with the nitrogen, may be a specified heterocyclic ring, are intermediates in the preparation of histamine H.sub.2 -antagonist anti-ulcer agents of the formula ##STR3## in which R.sup.1 and R.sup.2 are any of several specified substituents.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: March 5, 1985
    Assignee: Bristol-Myers Company
    Inventors: Aldo A. Algieri, Ronnie R. Crenshaw