Patents by Inventor Aldo Peschiulli

Aldo Peschiulli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MACROCYCLIC 7-PYRAZOL-5-YL-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230265105
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: May 27, 2021
    Publication date: August 24, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Aldo PESCHIULLI, Samuël Dominique DEMIN, Adriana-Ingrid VELTER, Matthieu Dominique JOUFFROY
  • MACROCYCLIC ETHER CONTAINING INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230250109
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: July 8, 2021
    Publication date: August 10, 2023
    Inventors: Benoît Christian Albert Ghislain DE BOECK, Petrus Jacobus Johannes Antonius BUIJNSTERS, Sofia FERRER CABRERA, Aldo PESCHIULLI, Tristan REUILLON, Frederik Jan Rita ROMBOUTS, Adriana-Ingrid VELTER
  • N-LINKED MACROCYCLIC 7-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBIORS OF MCL-1
    Publication number: 20230234969
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 27, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Benoit Christian Albert Ghislain DE BOECK, Aldo PESCHIULLI, Adriana-Ingrid VELTER
  • N-LINKED MACROCYCLIC 4-(PYRAZOL-5-YL)-INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230234965
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: June 18, 2021
    Publication date: July 27, 2023
    Inventors: Aldo PESCHIULLI, Frederik Jan Rita ROMBOUTS, Adriana-Ingrid VELTER
  • MACROCYCLIC INDOLE DERIVATIVES AS INHIBITORS OF MCL-1
    Publication number: 20230130109
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: February 18, 2021
    Publication date: April 27, 2023
    Inventors: Frederik Jan Rita ROMBOUTS, Tristan REUILLON, Aldo PESCHIULLI, Adriana-Ingrid VELTER, Ann Marleen VOS
  • MACROCYCLIC INHIBITORS OF MCL-1
    Publication number: 20220306653
    Abstract: The present invention relates to pharmaceutical agents useful for therapy and/or prophylaxis in a subject, pharmaceutical composition comprising such compounds, and their use as MCL-1 inhibitors, useful for treating diseases such as cancer.
    Type: Application
    Filed: June 18, 2020
    Publication date: September 29, 2022
    Inventors: Frederik Jan Rita ROMBOUTS, Aldo PESCHIULLI
  • Kinetic resolution
    Patent number: 9346755
    Abstract: While methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.
    Type: Grant
    Filed: September 25, 2014
    Date of Patent: May 24, 2016
    Assignee: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH, NEAR DUBLIN TRINITY COLLEGE, UNIVERSITY OF DUBLIN
    Inventors: Stephen Joseph Connon, Aldo Peschiulli, Barbara Procuranti
  • KINETIC RESOLUTION
    Publication number: 20150073170
    Abstract: Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.
    Type: Application
    Filed: September 25, 2014
    Publication date: March 12, 2015
    Applicant: THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF THE BOARD, OF THE COLLEGE OF THE
    Inventors: Stephen Joseph CONNON, Aldo PESCHIULLI, Barbara PROCURANTI
  • Kinetic resolution
    Patent number: 8946429
    Abstract: While methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.
    Type: Grant
    Filed: December 7, 2010
    Date of Patent: February 3, 2015
    Assignee: The Provost, Fellows, Foundation Scholars, and the other Members of the Board, of the College of the Holy and Undivided Trinity of Queen Elizabeth, Near Dublin
    Inventors: Stephen Joseph Connon, Aldo Peschiulli, Barbara Procuranti
  • Intermediates in the enantioselective synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid
    Patent number: 8476441
    Abstract: (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.
    Type: Grant
    Filed: January 29, 2010
    Date of Patent: July 2, 2013
    Assignee: The Provost, Fellows and Scholars of the College of the Holy and Undivided Trinity of Queen Elizabeth Near Dublin
    Inventors: Stephen Joseph Connon, Aldo Peschiulli, Lyn Markey
  • KINETIC RESOLUTION
    Publication number: 20120277437
    Abstract: Whilst methodologies for the Kinetic Resolution of alcohols are well established, no analogous direct methods exist for the highly selective, direct catalytic Kinetic Resolution of thiols (i.e., R—SH). The present invention relates to a method for resolving stereoisomeric mixtures of thiols. In particular, the present invention relates to purely organocatalytic mediated resolution of enantiomeric mixtures of thiols without the need for enzymes. Also disclosed are some novel catalysts. Such catalysts may comprise a cinchona alkaloid-derived moiety.
    Type: Application
    Filed: December 7, 2010
    Publication date: November 1, 2012
    Applicant: THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY
    Inventors: Stephen Joseph Connon, Aldo Peschiulli, Barbara Procuranti
  • INTERMEDIATES IN THE ENANTIOSELECTIVE SYNTHESIS OF 3-(AMINOMETHYL)-5-METHYL-HEXANOIC ACID
    Publication number: 20120046468
    Abstract: (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid or (S)-pregabalin is an anticonvulsive drug. In addition to its use as an anticonvulsive agent, pregabalin has also been indicated as a medicament in the treatment of anxiety, neuropathic pain and pain in patients with fibromyalgia. Provided herein are thioester intermediates in the synthesis of and processes for the synthesis of 3-(aminomethyl)-5-methyl-hexanoic acid in the (R) or (S) configuration.
    Type: Application
    Filed: January 29, 2010
    Publication date: February 23, 2012
    Applicant: THE PROVOST,FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY LAND AND UNDIVIDED TRINITY OF QUEEN ELIZ
    Inventors: Stephen Joseph Connon, Aldo Peschiulli, Lyn Markey