Abstract: A new process for the preparation of bicyclic peptide compounds Formula (I) in high yields of high purity, useful as intermediates for preparing compounds with pharmacological activity, is described.

Abstract: The present invention relates to a new process carried out entirely in solution, for the preparation in high yields of high purity bicyclic peptide compounds of formula (I), useful as intermediates for preparing compounds with pharmacological activity.

Abstract: Process of preparing (E)-5-(2-bromovynyl)-2?-deoxyuridine (Brivudine) characterized in that halogen-free solvent selected form esters or cyclic ethers are used in the bromination step of 5-ethyl-2?-deoxyuridine diacylate. The use of solvents is advantageous in respect of toxicity, discharge costs and environment protection.

Abstract: The present invention relates to the preparation of (E)-5-(2-bromovynyl)-2′-deoxyuridine (Brivudine) characterized in that halogen-free solvents selected form esters or cyclic ethers are used in the bromination step of 5-ethyl-2′deoxyuridine diacy-late. The use of said solvents is advantageous in respect of toxicity, discharge costs and environment protection.

Abstract: N-3-substituted pyrimindin-4-ones with angiotension II (AII) antagonistic activity are characterized by the presence of a heterocyclic moiety bound to the 3-position of the pyrimidinone ring and a biphenylmethyl moiety bound to the 5-position of the pyrimidinone ring. Preferred heterocyclic moieties include furan, thiophene, thiazole, isothiazole, oxazole, isoxazole, pyridine, pyrimidine, pyrazine, and pyridazine rings.

Abstract: Derivatives of bicyclic heterocycles comprising a pyrimidone ring fused to another 5, 6, or 7 membered nitrogen heterocycle which is C-substituted, through a methylene bridge, by a biphenyl group.

Abstract: Imidazole derivatives having A II antagonist activity, of Formula I, the processes for the preparation thereof, pharmaceutical compositions containing them and the use thereof as therapeutic agents. The described compounds having A II antagonist activity can be used in various cardiovascular disorders.

Abstract: This invention relates to diltiazem analogs having the formula: ##STR1## where the substituents are defined in the specification. These compounds are useful in treating cardiovascular problems. The invention also relates to a process for preparing the compounds and to pharmaceutical compositions containing the compounds.

Abstract: Compounds having a angiotensine II antagonistic activity ##STR1## Compounds of formula (I), wherein R, R.sub.1, R.sub.2, R.sub.3, X and Z groups have the meanings given in the specification and are endowed with AII antagonistic properties.

Abstract: Compounds of general formula (I) ##STR1## wherein E is O or S; R is C.sub.1 -C.sub.5 straight, branched or cyclic alkyl or C.sub.2 -C.sub.5 alkenyl; X can be H, F, Cl, Br, I, CF.sub.3 ; n is an integer 1 to 4; m is an integer 0 to 4; A and B are 5- or 6- membered aromatic carbocyclic rings optionally containing one or more heteroatoms selected from N, O, S and carrying the substituents R.sub.1, R.sub.2 and R.sub.3, respectively; R.sub.1 can be hydrogen, halogen, C.sub.1 -C.sub.4 alkoxycarbonyl, a sulfonic group or a tetrazole group of formula ##STR2## wherein R.sub.4 can be hydrogen or C.sub.1 -C.sub.5 alkyl; R.sub.2 can be hydrogen or a COOR.sub.4 group (wherein R.sub.4 is hydrogen or C.sub.1 -C.sub.5 alkyl), CN, SO.sub.3 H, PO.sub.3 H or a tetrazole group R.sub.3 ; can be a hydrogen or a moiety of formula (II)B'(R'.sub.2,R'.sub.3) (II)wherein: B.sup.1, R.sup.1.sub.2 have the same meanings reported above for B and R.sub.2, R'.sub.3 is H; with the proviso that when A is phenyl, R.sub.

Abstract: Invention concerns 4,5-bisubstituted-2-imidazolone derivatives of formula I ##STR1## and pharmaceutically acceptable salts thereof, having high affinity in vitro for D.sub.2, 5-HT.sub.2, .sub.1 receptors and in vivo activity on central nervous system and antihypertensive activity with negligible secondary effects; methods for the preparation thereof; pharmaceutical formulations containing them.

Abstract: 2,2-Disubstituted 2,3-dihydro-1,4-benzodioxin derivatives of formula (I): ##STR1## and pharmaceutically acceptable salts thereof having in vitro high affinity and selectively for .alpha..sub.1 receptors and in vivo good and long lasting hypotensive activty, with negligible side-effects; processes for the preparation thereof and pharmaceutical compositions therefrom.

Abstract: This invention relates to a series of thiazole derivatives having the general formula ##STR1## The compounds of the invention have an interesting diuretic activity and low toxicity.

Abstract: 3-(3-Hydroxybutoxy)-1-butanol having formula II and its stereoisomers and optical isomers, at the pure state, are described ##STR1## Processes for the purification of II and for the preparation of a pure diastereoisomer of II are described. Pharmaceutical compositions containing as the active ingredient compound II alone or combined with the isomeric ethers 4-(3-hydroxybutoxy)-2-butanol I and 3-(3-hydroxy-1-methylpropoxy)-1-butanol III.

Abstract: The invention provides novel esters of 1-(p-hydroxyphenyl)-2-(1'-methyl-2'-phenoxyethylamino)-1-propanol having better properties as vascular dilatators, than the corresponding 1-(p-hydroxyphenyl)-2-(1'-methyl-2-phenoxyethylamino)-1-propanol.

Abstract: 2,2-Disubstituted-1,3-benzodioxoles having anti-inflammatory, analgesic, antipyretic and antitussive action, inhibition or excitation of the central nervous system, local anaesthetic, anti-arrhythmic and anti-hypotensive action, and action inhibiting the aggregation of platelets.

Abstract: 1,4-Benzodioxan derivatives of the formula: ##STR1## IN WHICH Ar is an aryl group and X is --OR, where R is hydroxyalkyl, aminoalkyl, or aminoalkoxyalkyl, or ##STR2## where R.sub.1 and R.sub.2 are hydrogen, hydroxyl, alkyl, aryl, or aralkyl or are joined together to form an alkylene group which may contain an oxygen, sulphur or nitrogen hetero atom, have interesting pharmacological properties.

Abstract: The invention provides a new class of aminoalkoxyphenoxyalkenones having interesting pharmacological properties.

Abstract: 2,2 Disubstituted-1,3-benzodioxoles having anti-flammatory, analgesic, anti-pyretic and anti-tussive action, inhibition or excitation of the central nervous system, local anaesthetic, anti-arrhythmic and hypotensive action, and action inhibiting the aggregation of platelets.

Abstract: 2-Substituted benzodioxoles are useful as pharmaceuticals having e.g. anti-inflammatory, analgesic, antipyrretic, antitussive, C.N.S. depressant, local anaesthetic, antiarrythmic, antihistaminic action and hypolipidic action.